4-Defluoro 2-Fluoro Flunarizine Dihydrochloride

CAS: 2734416-95-4

Ref. TR-D228705

Product Information

• Name: 4-Defluoro 2-Fluoro Flunarizine Dihydrochloride
• Synonyms: Flunarizine Imp. C (EP), 1-[(RS)-(2-Fluorophenyl)(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-enyl]piperazine Dihydrochloride, Flunarizine Dihydrochloride Imp. C (EP) as Dihydrochloride, Cloxacillin Related Compound D, Cloxacillin Sodium Impurity D, Cloxacillin Impurity D, Flunarizine Impurity C Dihydrochloride, (E)-1-[(4-Fluoroohenyl)(2-fluorophenyl)methyl]-4-(cinnamyl)piperazine Dihydrochloride, 1-cinnamyl-4-((2-fluorophenyl)(4-fluorophenyl)methyl)piperazine dihydrochloride,3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic Acid, Flunarizine Dihydrochloride Imp. C (EP)

Description

Stability Hygroscopic
Applications 4-Defluoro 2-Fluoro Flunarizine Dihydrochloride is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral).
References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)

• Brand: TRC

Chemical properties

• Molecular weight: 404.4923646
• Formula: C₂₆H₂₆F₂N₂HCl
• Color/Form: White Solid
• InChI: InChI=1S/C26H26F2N2.2ClH/c27-23-14-12-22(13-15-23)26(24-10-4-5-11-25(24)28)30-19-17-29(18-20-30)16-6-9-21-7-2-1-3-8-21;;/h1-15,26H,16-20H2;2*1H/b9-6+
• InChI key: InChIKey=JIEUHXPBQRNCKS-RMKNXTFCSA-N
• SMILES: Fc1ccc(C(c2ccccc2F)N2CCN(C/C=C/c3ccccc3)CC2)cc1