3-Descyano Febuxostat

CAS: 1206550-99-3

Ref. TR-D289705

Product Information

• Name: 3-Descyano Febuxostat
• Synonyms: 2-(4-Isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid, 5-Thiazolecarboxylic acid, 4-methyl-2-[4-(2-methylpropoxy)phenyl]-, 2-(4-Isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid, 4-Methyl-2-[4-(2-methylpropoxy)phenyl]-5-thiazolecarboxylic acid

Description

Applications 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Kadivar, M.H., et. al.: J. Pharmaceut. Biomed. Anal., 56, 749 (2011); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 291.37
• Formula: C₁₅H₁₇NO₃S
• Color/Form: Neat
• InChI: InChI=1S/C15H17NO3S/c1-9(2)8-19-12-6-4-11(5-7-12)14-16-10(3)13(20-14)15(17)18/h4-7,9H,8H2,1-3H3,(H,17,18)
• InChI key: InChIKey=ZDKJCYASUIQELO-UHFFFAOYSA-N
• SMILES: Cc1nc(-c2ccc(OCC(C)C)cc2)sc1C(=O)O