3-Descyano Febuxostat-d9 Ethyl Ester

CAS: 144060-97-9

Ref. TR-D289712

Product Information

• Name: 3-Descyano Febuxostat-d9 Ethyl Ester
• Synonyms: ethyl 2-[4-[1,1,2,3,3,3-hexadeuterio-2-(trideuteriomethyl)propoxy]phenyl]-4-methyl-1,3-thiazole-5-carboxylate, 5-Thiazolecarboxylic acid, 4-methyl-2-[4-(2-methylpropoxy)phenyl]-, ethyl ester, Ethyl 4-methyl-2-[4-(2-methylpropoxy)phenyl]-5-thiazolecarboxylate

Description

Applications 3-Descyano Febuxostat-d9 Ethyl Ester is the labeled analogue of 3-Descyano Febuxostat Ethyl Ester (D289710), an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 328.474
• Formula: C₁₇D₉H₁₂NO₃S
• Color/Form: Neat
• InChI: InChI=1S/C17H21NO3S/c1-5-20-17(19)15-12(4)18-16(22-15)13-6-8-14(9-7-13)21-10-11(2)3/h6-9,11H,5,10H2,1-4H3/i2D3,3D3,10D2,11D
• InChI key: InChIKey=LJRMNYUTCKYZJR-OGCMBCFSSA-N
• SMILES: [2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])C([2H])([2H])Oc1ccc(-c2nc(C)c(C(=O)OCC)s2)cc1