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Di-(tert-Butyl-dimethylsilyl) Curcumin
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Di-(tert-Butyl-dimethylsilyl) Curcumin

CAS: 1134639-23-8

Ref. TR-D428050

25mg
259.00 €
250mg
1,755.00 €
Estimated delivery in United States, on Tuesday 21 May 2024

Product Information

Name:
Di-(tert-Butyl-dimethylsilyl) Curcumin
Synonyms:
  • (1E,4Z,6E)-1,7-Bis[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1,4,6-heptatrien-3-one
Description:

Applications Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),

Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
596.9
Formula:
C33H48O6Si2
Color/Form:
Yellow Solid
InChI:
InChI=1S/C33H48O6Si2/c1-32(2,3)40(9,10)38-28-19-15-24(21-30(28)36-7)13-17-26(34)23-27(35)18-14-25-16-20-29(31(22-25)37-8)39-41(11,12)33(4,5)6/h13-23,34H,1-12H3/b17-13+,18-14+,26-23-
InChI key:
InChIKey=YTANFSVGWHEWKY-MVRVVBEHSA-N
SMILES:
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O[Si](C)(C)C(C)(C)C)c(OC)c2)ccc1O[Si](C)(C)C(C)(C)C
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
Hazard Info:
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LQ:

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