Dolutegravir Tetra-O-acetyl- O-Beta-D-glucoside
Ref. TR-D528830
| 50mg | Discontinued | ||
| 100mg | Discontinued | ||
| 250mg | Discontinued |
Product Information
Name:
Dolutegravir Tetra-O-acetyl- O-Beta-D-glucoside
Synonyms:
- (2R,3R,5R,6S)-2-(Acetoxymethyl)-6-(((4R,12aS)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Description:
Applications Dolutegravir Tetra-O-acetyl- O-β-D-glucoside is an intermediate in the synthesis of Dolutegravir O-β-D-Glucoside (D528815) which is a metabolite of Dolutegravir (D528800); a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
749.67
Formula:
C34H37F2N3O14
Color/Form:
Pale Brown Foam
InChI:
InChI=1S/C34H37F2N3O14/c1-15-8-9-47-25-13-38-12-22(32(45)37-11-20-6-7-21(35)10-23(20)36)27(44)29(26(38)33(46)39(15)25)53-34-31(51-19(5)43)30(50-18(4)42)28(49-17(3)41)24(52-34)14-48-16(2)40/h6-7,10,12,15,24-25,28,30-31,34H,8-9,11,13-14H2,1-5H3,(H,37,45)/t15-,24-,25+,28-,30?,31-,34+/m1/s1
InChI key:
InChIKey=XSQUCXPUDIKVPN-WZQOJGDESA-N
SMILES:
CC(=O)OC[C@H]1O[C@@H](Oc2c3n(cc(C(=O)NCc4ccc(F)cc4F)c2=O)C[C@@H]2OCC[C@@H](C)N2C3=O)[C@H](OC(C)=O)C(OC(C)=O)[C@@H]1OC(C)=O
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