11,17-Dihydroxy-3-oxo-pregn-4-ene-21-carboxylic Acid γ-​Lactone

CAS: 41850-19-5

Ref. TR-D883520

Product Information

• Name: 11,17-Dihydroxy-3-oxo-pregn-4-ene-21-carboxylic Acid γ-​Lactone
• Synonyms: (2'R,8S,9S,10R,11R,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
• Brand: TRC
• Description: Applications 11,17-Dihydroxy-3-oxo-pregn-4-ene-21-carboxylic Acid γ-​Lactone is an intermediate in the synthesis of Des-methylformate Eplerenone (D293955) which is an impurity of Eplerenone (E588775), a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Chemical properties

• Molecular weight: 358.471
• Formula: C₂₂H₃₀O₄
• Color/Form: Neat
• InChI: InChI=1S/C22H30O4/c1-20-8-5-14(23)11-13(20)3-4-15-16-6-9-22(10-7-18(25)26-22)21(16,2)12-17(24)19(15)20/h11,15-17,19,24H,3-10,12H2,1-2H3/t15-,16-,17+,19?,20-,21?,22+/m0/s1
• InChI key: InChIKey=VKQZKUPABHSTTG-GHCDIQHGSA-N
• SMILES: CC12C[C@@H](O)C3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@]21CCC(=O)O1