Product Information
- Phenazone Imp. A (EP)
- Antipyrine USP Related Compound A
- Antipyrine USP RC A
- 2-Pyrazolin-5-one
- 3-methyl-1-phenyl- (8CI)
- 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
- 1-Phenyl-3-methyl-2-pyrazolin-5-one
- 1-Phenyl-3-methyl-5-oxopyrazole
- 1-Phenyl-3-methyl-5-pyrazolinone
- See more synonyms
- 1-Phenyl-3-methyl-5-pyrazolone
- 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
- 3-Methyl-1-phenyl-1H-pyrazol-5-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3-Methyl-1-phenyl-2-pyrazoline-5-one
- 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
- 3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one
- 3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one
- 3-Methyl-1-phenyl-5-pyrazolone
- 3-Methyl-1-phenylpyrazol-5(4H)-one
- 3-Methyl-1-phenylpyrazolin-5-one
- 4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole
- 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
- 5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one
- 5-Methyl-2-phenylpyrazol-3-one
- C.I. Developer 1
- Developer Z
- Edarabone
- Edaravone
- Edvaradone
- MCI 186
- Methylphenylpyrazolone
- NCI-C 03952
- NSC 12
- NSC 26139
- NSC 2629
- Norantipyrine
- Norphenazone
- Phenylmethyl pyrazolone
- Radicava
- Radicut
- Antipyrine Related Compound A
- Phenazone Impurity A
- 1,3,5-Pmp
- 1-Fenil-3-Metil-5-Pirazolona
- 1-Phenyl-3-Methyl-5-Prazalone
- 1-Phenyl-3-Methyl-5-Pyrazole
- 1-Phenyl-3-Methyl-5-Pyrazolone
- 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-On
- 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-One
- 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazole-3-one
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-5-pyrazolon
- 3-Methyl-1-phenylpyrazol-5-one
- 3-Methyl-1-phenylpyrazole-5-one
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
- 5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one
- Edaravon
- Mci-186
- Nci-C 03952
- Nsc 12
- Nsc 26139
- Nsc 2629
- PMP
- Pyrazolin(2)-5-One, 3-Methyl-1-Phenyl-
Impurity Phenazone EP Impurity A
Applications Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
References Reeta KH et al. Eur J Neurosci. 2017 Feb 15Masuda T et al. Oxid Med Cell Longev. 2017;2017:9208489Zhang DY et al. J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):51-56Criswell LA et al. Am J Med. 2002 Apr 15;112(6):465-71.
Chemical properties
Technical inquiry about: TR-E335000 3-Methyl-1-phenyl-2-pyrazolin-5-one(Edaravone)
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