Product Information
Name:
GSK 5072 Dihydrochloride
Synonyms:
- 5-(((4-Chlorobenzyl)(pyridin-3-ylmethyl)amino)methyl)thiophene-2-carbonitrile Dihydrochloride
- 5-[[[(4-Chlorophenyl)methyl](3-pyridinylmethyl)amino]methyl]-2-thiophenecarbonitrile Dihydrochloride
Description:
Applications GSK 5072 Dihydrochloride is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
References Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010); Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011);
Notice:
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Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
353.8723646
Formula:
C19H16ClN3S• 2(HCl)
Color/Form:
White to Pale Yellow Solid
MDL:
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