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5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)
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5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)

CAS: 504413-73-4

Ref. TR-H954455

1mg
260.00 €
10mg
1,747.00 €
Estimated delivery in United States, on Tuesday 23 Apr 2024

Product Information

Name:
5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)
Synonyms:
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-
  • (4S)-
  • (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin
Description:

Stability Hygroscopic
Applications Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990), BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991), Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992),

Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
437.45
Formula:
C23H23N3O6
Color/Form:
Yellow to Dark Orange Solid
InChI:
InChI=1S/C23H23N3O6/c1-4-23(31)15-8-17-19-12(20(28)26(17)21(29)14(15)10-32-22(23)30)7-11-13(9-25(2)3)18(27)6-5-16(11)24-19/h5-8,20,27-28,31H,4,9-10H2,1-3H3/t20?,23-/m0/s1
InChI key:
InChIKey=IKBVYIZOTSVDNQ-AKRCKQFNSA-N
SMILES:
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)C(O)c2cc3c(CN(C)C)c(O)ccc3nc2-1
MDL:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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