beta-Lumi (-)-Colchicine

CAS: 6901-13-9

Ref. TR-L474300

Product Information

• Name: beta-Lumi (-)-Colchicine
• Synonyms: N-[(7S,7bR,10aS)-1,2,3,9-Tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide, Colchicine Imp. C (EP), N-[(7S,7bR,10aS)-1,2,3,9-Tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo-[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide, N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide, [7S-(7.alpha.,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide, beta-Lumicolchicine, Benzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cycloheptene, acetamide deriv., (−)-beta-Lumicolchicine, Lumicolchicine, NSC 221661, NSC 56233, Colchicine Impurity C, (-)-β-Lumicolchicine, (7S-(7alpha,7bbeta,10abeta))-N-(5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo(a)cyclopenta(3,4)cyclobuta(1,2-c)cyclohepten-7-yl)acetamide, Acetamide, N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)-, [7S-(7α,7bβ,10aβ)]-, Acetamide, N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]-, Benzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cycloheptene, acetamide deriv., Lumicolchicine (9CI), N-(1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl)acetamide, N-[(7R,7bS,10aR)-1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl]acetamide, N-[(7S,7bR,10aS)-1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl]acetamide, Nsc 221661, Nsc 56233, β-Lumi-(-)-colchicine
• CAS: 6901-13-9

Description

Applications An analog of Colchicine (C640000), β-lumicolchicine, does not bind tubulin or disrupt microtubules. A GABAA receptor chloride channel.
References Andreu, J., et al.: Biochemistry, 37, 8356 (1998), Weiner, J., et al.: J. Pharmacol. Exp. Ther., 284, 95 (1998), Hong, G., et al.: J. Pharm. Sci., 88, 147 (1999),

• Brand: TRC

Chemical properties

• Molecular weight: 399.44
• Formula: C₂₂H₂₅NO₆
• Color/Form: Off-White to Pale Orange Solid
• InChI: InChI=1S/C22H25NO6/c1-10(24)23-13-7-6-11-8-15(27-3)21(28-4)22(29-5)16(11)17-12-9-14(26-2)20(25)18(12)19(13)17/h8-9,12-13,18H,6-7H2,1-5H3,(H,23,24)/t12-,13+,18-/m1/s1
• InChI key: InChIKey=VKPVZFOUXUQJMW-FHSNZYRGSA-N
• SMILES: COC1=C[C@@H]2C3=C([C@@H](NC(C)=O)CCc4cc(OC)c(OC)c(OC)c43)[C@@H]2C1=O