Methyl 4-[(5-Amino-1-methylindol-3-yl)methyl]-3-methoxybenzoate

CAS: 107754-14-3

Ref. TR-M258650

Product Information

• Name: Methyl 4-[(5-Amino-1-methylindol-3-yl)methyl]-3-methoxybenzoate
• Synonyms: 4-[(5-Amino-1-methyl-1H-indol-3-yl)methyl]-3-methoxy-benzoic Acid Methyl Ester, 3-Methoxy-4-(1-Methyl-5-Aminoindol-3-Ylmethyl)Benzoate

Description

Applications Methyl 4-[(5-Amino-1-methylindol-3-yl)methyl]-3-methoxybenzoate is an intermediate used in the preparation of Zafirlukast (Z125000), a potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist.
References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990); Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992); Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990); Dunn, C.J., Drugs, 61, 285 (2001); Goverdhan, G., et al.: J. Pharma. Biomed. Anal., 49, 895 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 324.37
• Formula: C₁₉H₂₀N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C19H20N2O3/c1-21-11-14(16-10-15(20)6-7-17(16)21)8-12-4-5-13(19(22)24-3)9-18(12)23-2/h4-7,9-11H,8,20H2,1-3H3
• InChI key: InChIKey=WEMIOTLFXSHMSS-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(Cc2cn(C)c3ccc(N)cc23)c(OC)c1