Panobinostat (LBH-589)

CAS: 404950-80-7

Ref. TR-P180500

Product Information

• Name: Panobinostat (LBH-589)
• Synonyms: 2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-, (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide, Farydak, LBH 589, Panobinostat, (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide, (E)-N-Hydroxy-3-(4-{[2-(2-Methyl-1H-Indol-3-Yl)-Ethylamino]-Methyl}-Phenyl)-Acrylamide, 2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-, Lbh-589, N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide, Nvp-Lbh-589
• CAS: 404950-80-7

Description

Applications The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Potent Histone deacetylase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Claus, R., et al.: Oncogene, 22, 6489 (2003), Johnstone, R., et al.: Cancer Cell., 4, 13 (2003), Ying, J., et al.: Clin. Cancer Res., 11, 6442 (2005), Catley, L., et al.: Blood, 108, 3441 (2006), Steinberg, M., et al.: Clin. Ther., 29, 2289 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 349.43
• Formula: C₂₁H₂₃N₃O₂
• Color/Form: White to Yellow Solid
• InChI: InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
• InChI key: InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N
• SMILES: Cc1[nH]c2ccccc2c1CCNCc1ccc(/C=C/C(=O)NO)cc1