N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt

CAS: 17388-80-6

Ref. TR-S688790

Product Information

• Name: N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt
• Synonyms: N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic acid disodium salt, N-(5-Amino-1-ribosyl-4-imidazolecarbonyl)-L-aspartic acid disodium salt, N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic acid disodium salt, Acadesi
• CAS: 17388-80-6

Description

Applications A metabolite of Purine. Purine metabolism by adenylosuccinasedeficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

• Brand: TRC

Chemical properties

• Molecular weight: 418.267
• Formula: C₁₃H₁₆N₄Na₂O₉
• Color/Form: White to Yellow Solid
• InChI: 2*+1/p-2/t4-,5+,8+,9+,12+, , /m0../s1, /q, /h3-5,8-9,12,18,21-22H,1-2,14H2,(H,16,23)(H,19,20)(H,24,25), , InChI=1S/C13H18N4O9.2Na/c14-10-7(11(23)16-4(13(24)25)1-6(19)20)15-3-17(10)12-9(22)8(21)5(2-18)26-12,
• InChI key: InChIKey=ZZPKVAPCMROQPH-KGBHUAOWSA-L
• SMILES: Nc1c(C(=O)N[C@@H](CC(=O)O[Na])C(=O)O[Na])ncn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O