Product Information
Name:
SAK3
Synonyms:
- SAK 3
- Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Description:
Applications SAK3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors in OBX mice. Orally bioavailable.
References Abe, Takashi., et al.: Heterocycles., 81, 2075 (2010); Yabuki, Y., et al.:Neuropharmacology, 117, 1-13. (2017)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
369.41
Formula:
C20H23N3O4
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C20H23N3O4/c1-3-27-18(25)15-14(24)12-20(16(15)22-9-5-4-6-10-22)19(26)21-17-13(2)8-7-11-23(17)20/h7-8,11H,3-6,9-10,12H2,1-2H3
InChI key:
InChIKey=WZHBYTVHUFURPY-UHFFFAOYSA-N
SMILES:
CCOC(=O)C1=C(N2CCCCC2)C2(CC1=O)C(=O)N=C1C(C)=CC=CN12
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