CAS: 1448347-49-6 - Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

Fórmula: C₂₈H₂₂ClF₃N₆O₃

InChI: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

Chave InChI: InChIKey=WIJZXSAJMHAVGX-DHLKQENFSA-N

SMILES: N#CC=1C=CN=C(C1)N2C(=O)CCC2C(=O)N(C=3C=NC=C(F)C3)C(C(=O)NC4CC(F)(F)C4)C=5C=CC=CC5Cl

Sinónimos:

• Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-
• Ivosidenib
• (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• AG 120

RG120

CAS: 1448347-49-6

• Fórmula: C₂₈H₂₂ClF₃N₆O₃
• Pureza: 98%
• Cor e Forma: Solid
• Peso molecular: 582.9609

Ivosidenib

CAS: 1448347-49-6

Ivosidenib (AG-120) is an oral IDH1 inhibitor targeting mutated IDH1 to reduce 2-hydroxyglutarate and hinder …

• Fórmula: C₂₈H₂₂ClF₃N₆O₃
• Pureza: 100% - 99.7%
• Cor e Forma: Solid
• Peso molecular: 582.96

Ivosidenib

CAS: 1448347-49-6

Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. …

• Fórmula: C₂₈H₂₂ClF₃N₆O₃
• Cor e Forma: Neat
• Peso molecular: 582.96

AG 120

CAS: 1448347-49-6

Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes …

• Fórmula: C₂₈H₂₂ClF₃N₆O₃
• Pureza: Min. 95%
• Cor e Forma: White To Off-White Solid
• Peso molecular: 582.96 g/mol