CAS 161797-99-5

Etil 2-(4-hidroxifenil)-4-metil-5-tiazolcarboxilato

Descrição:

Etil 2-(4-hidroxifenil)-4-metil-5-tiazolcarboxilato, com o número CAS 161797-99-5, é um composto orgânico caracterizado por seus grupos funcionais de tiazol e fenólico. Este composto geralmente aparece como uma substância sólida ou cristalina e é conhecido por suas potenciais aplicações em farmacêuticos e agroquímicos devido à sua atividade biológica. A presença do grupo éster etílico contribui para sua solubilidade em solventes orgânicos, enquanto o grupo hidroxila no anel fenílico pode aumentar sua reatividade e capacidade de formar ligações de hidrogênio. O anel de tiazol é conhecido por seu papel em vários processos biológicos, tornando este composto de interesse na química medicinal. Sua estrutura molecular sugere interações potenciais com alvos biológicos, o que pode levar a vários efeitos terapêuticos. Além disso, a estabilidade e reatividade do composto podem ser influenciadas por fatores ambientais, como pH e temperatura, que são considerações importantes em sua aplicação e manuseio. No geral, este composto exemplifica a complexidade e utilidade dos compostos heterocíclicos na pesquisa e desenvolvimento químico.

Fórmula: C₁₃H₁₃NO₃S

InChI: InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3

Chave InChI: InChIKey=LOCYSKNNFCGDTR-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1SC(=NC1C)C2=CC=C(O)C=C2

Sinónimos:

• 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester
• 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester
• Ethyl 2-(4-HydroxyPhenyl)-4-Methyl Thiazole-5-Carboxylate
• Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
• Ethyl-2-(4-Hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
• Ethyl2-(4-hydroxy phenyl)-4-methylthiazole-5-carboxylate
• Febuxostat N-2

5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester

CAS: 161797-99-5

Fórmula: C₁₃H₁₃NO₃S

Pureza: 96%

Cor e Forma: Solid

Peso molecular: 263.3122

Ref: IN-DA001VVY

Febuxostat Impurity 39

CAS: 161797-99-5

Fórmula: C₁₃H₁₃NO₃S

Cor e Forma: White To Off-White Solid

Peso molecular: 263.31

Ref: 4Z-F-3953

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

CAS: 161797-99-5

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

Pureza: 98%

Peso molecular: 263.31g/mol

Ref: 54-OR1013139

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

Fórmula: C₁₃H₁₃NO₃S

Cor e Forma: Neat

Peso molecular: 263.31

Ref: TR-E918910

Febuxostat Descyano Hydroxy Ethyl Ester

CAS: 161797-99-5

Fórmula: C₁₃H₁₃NO₃S

Peso molecular: 263.31

Ref: ST-EA-CP-F7041

2-(4-Hydroxyphenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester

CAS: 161797-99-5

Fórmula: C₁₃H₁₃NO₃S

Pureza: 96%

Cor e Forma: Solid

Peso molecular: 263.31

Ref: 10-F025271

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is an anticancer agent that belongs to the class of formamidines. It is synthesized by refluxing ethyl 4-hydroxyphenylacetic acid with hexamethylenetetramine and acetic acid in ethanol. After purification, it is converted to its active form by reacting with hydrochloric acid. Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate prevents the growth of cancer cells in culture by preventing DNA synthesis, which prevents RNA and protein synthesis. This agent has also been found to suppress paclitaxel production in cultured human breast cancer cells.

Fórmula: C₁₃H₁₃NO₃S

Pureza: Min. 95%

Peso molecular: 263.31 g/mol

Ref: 3D-FE15829