CAS 339990-02-2

L-a-Asparagina, N-acetil-L-leucil-L-prolil-L-fenilalanil-L-fenilalanil-

Descrição:

A L-a-Asparagina, N-acetil-L-leucil-L-prolil-L-fenilalanina-L-fenilalanina, identificada pelo número CAS 339990-02-2, é um peptídeo sintético que consiste em uma sequência de aminoácidos, incluindo asparagina, leucina, prolina e fenilalanina. Este composto é caracterizado por sua disposição específica desses aminoácidos, que contribui para suas propriedades únicas e potenciais atividades biológicas. Peptídeos como este frequentemente exibem várias funções em sistemas biológicos, incluindo papéis na sinalização, atividade enzimática e suporte estrutural. A modificação N-acetil tipicamente melhora a estabilidade e solubilidade do peptídeo, tornando-o mais adequado para várias aplicações em pesquisa e farmacêutica. Além disso, a presença de aminoácidos aromáticos, como a fenilalanina, pode influenciar as interações do peptídeo com outras biomoléculas. No geral, este composto representa uma estrutura complexa que pode ser de interesse em estudos relacionados à bioquímica, farmacologia e síntese de peptídeos.

Fórmula: C₃₅H₄₆N₆O₈

Sinónimos:

• 10:PN: WO03050139 SEQID: 15 claimed protein
• 3: PN: WO0134631 PAGE: 35 claimedprotein
• As 602704
• Ac-Leu-Pro-Phe-Phe-Asp-Nh2

Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide

CAS: 339990-02-2

The pentapeptide Ac-LPFFD-NH₂ (iAβ5p) is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p.

Fórmula: C₃₅H₄₆N₆O₈

Pureza: > 95%

Cor e Forma: White Powder

Peso molecular: 678.79

Ref: 01-4045708

Ac-Leu-Pro-Phe-Phe-Asp-NH2

CAS: 339990-02-2

Ac-Leu-Pro-Phe-Phe-Asp-NH2 is a potential therapeutic for Alzheimer's disease. It has been shown to reduce the production of reactive oxygen species and inhibit the formation of amyloid beta oligomers. Ac-Leu-Pro-Phe-Phe-Asp-NH2 also reduces the frequency of protofibrils, which are aggregates that may play a role in Alzheimer's disease pathology. This peptide has been shown to have a protective effect on cell populations, which may lead to therapeutics that can delay or prevent Alzheimer's disease. Ac-Leu-Pro-Phe-Phe-Asp NH2 is an inhibitor of amyloid beta peptides and modulates their aggregation into protofibrils.

Fórmula: C₃₅H₄₆N₆O₈

Pureza: Min. 95%

Peso molecular: 678.89 g/mol

Ref: 3D-PAB-3632-PI

Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide

CAS: 339990-02-2

Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a peptide that was generated by incubating β-amyloid with the protease papain. This peptide has been shown to induce population and biochemical changes in cells, including focusing of β-amyloid aggregates. It also induces reactive oxygen species and promotes extracellular protofibril formation. Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a conjugate of acetylated lysine residues and amyloid β-protein that can be used as an anti-amyloid therapeutic. The peptide is characterized by dichroism spectroscopy, which has revealed its specific binding to the fibrils' surface.

Fórmula: C₃₅H₄₆N₆O₈

Pureza: Min. 95%

Peso molecular: 678.78 g/mol

Ref: 3D-FA109732