Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5592 produtos de "Apoptose"
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Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Fórmula:C26H46NNaO7SPureza:99.95%Cor e Forma:SolidPeso molecular:539.70Caudatin
CAS:<p>Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities.</p>Fórmula:C28H42O7Pureza:98.83% - 99.9%Cor e Forma:SolidPeso molecular:490.63MG-132
CAS:<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Fórmula:C26H41N3O5Pureza:95% - 99.99%Cor e Forma:White To Off-White PowderPeso molecular:475.62K-Ras(G12C) inhibitor 12
CAS:<p>K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C15H17ClIN3O3Pureza:97.16%Cor e Forma:SolidPeso molecular:449.67DL-Buthionine-(S,R)-sulfoximine
CAS:<p>DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.</p>Fórmula:C8H18N2O3SPureza:98% - 99.64%Cor e Forma:White Fine PowderPeso molecular:222.31D-Saccharic acid 1,4-lactone hydrate
CAS:<p>D-Saccharic acid 1,4-lactone hydrate inhibits β-glucuronidase (IC50=48.4 μM); has anticarcinogenic, detoxifying, antioxidant traits.</p>Fórmula:C17H20ClN3OPureza:99.49% - ≥98%Cor e Forma:SolidPeso molecular:317.815'-Methylthioadenosine
CAS:<p>5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.</p>Fórmula:C11H15N5O3SPureza:99.32% - 99.34%Cor e Forma:SolidPeso molecular:297.33Sulfaphenazole
CAS:<p>Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for</p>Fórmula:C15H14N4O2SPureza:97.53% - 99.67%Cor e Forma:SolidPeso molecular:314.36DMU-212
CAS:<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Fórmula:C18H20O4Pureza:99.86%Cor e Forma:SolidPeso molecular:300.35Verteporfin
CAS:<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Fórmula:C41H42N4O8Pureza:95.37% - 99.82%Cor e Forma:Dark Green To Black SolidPeso molecular:718.79Britannin
CAS:<p>Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.</p>Fórmula:C19H26O7Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:366.41SC99
CAS:<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Fórmula:C15H8Cl2FN3OPureza:99.56%Cor e Forma:SolidPeso molecular:336.15Thalidomide-NH-C6-NH2 hydrochloride
CAS:<p>Pomalidomide-C6-NH2 HCl is a synthetic conjugate for PROTAC, combining CRBN ligand and linker.</p>Fórmula:C19H25ClN4O4Pureza:99.27%Cor e Forma:SolidPeso molecular:408.88Piperazine Erastin
CAS:<p>Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.</p>Fórmula:C35H41ClN6O4Pureza:99.52%Cor e Forma:SolidPeso molecular:645.19(20S)-Protopanaxatriol
CAS:<p>(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid</p>Fórmula:C30H52O4Pureza:95% - 99%Cor e Forma:SolidPeso molecular:476.73Psoralen
CAS:<p>Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.</p>Fórmula:C11H6O3Pureza:99.3% - 99.87%Cor e Forma:Crystals From Ether Crystalline SolidPeso molecular:186.16Thalidomide-propargyl
CAS:<p>Thalidomide-propargyl, a Cereblon ligand, links proteins in PROTAC formation.</p>Fórmula:C16H12N2O5Pureza:95.14%Cor e Forma:SolidPeso molecular:312.28Sodium Oxamate
CAS:<p>Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA.</p>Fórmula:C2H2NNaO3Pureza:99.23% - ≥98%Cor e Forma:White Crystalline PowderPeso molecular:111.03Ketorolac hemicalcium
CAS:<p>Ketorolac hemicalcium: NSAID, COX-1/COX-2 inhibitor (IC50: 20/120 nM), treats eye inflammation & pain, used in cancer research.</p>Fórmula:C30H24CaN2O6Cor e Forma:SolidPeso molecular:548.608Mocetinostat
CAS:<p>Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.</p>Fórmula:C23H20N6OPureza:99% - 99.21%Cor e Forma:SolidPeso molecular:396.44Perhexiline
CAS:<p>Perhexiline: oral CPT1/2 inhibitor, limits fat metabolism, crosses BBB, anti-cancer, induces liver cell apoptosis, for cancer/cardio research.</p>Fórmula:C19H35NCor e Forma:SolidPeso molecular:277.49KRCA-0008
CAS:<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Fórmula:C30H37ClN8O4Pureza:96.19%Cor e Forma:SolidPeso molecular:609.12Carnosic acid
CAS:<p>Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.</p>Fórmula:C20H28O4Pureza:98.31% - 99.5%Cor e Forma:Yellow PowderPeso molecular:332.43Bigelovin
CAS:<p>Bigelovin: RXRα agonist, inhibits mTOR via ROS, induces apoptosis/autophagy, anti-tumor sesquiterpene from Inula sp.</p>Fórmula:C17H20O5Pureza:99.61% - 99.72%Cor e Forma:SolidPeso molecular:304.34Vandetanib trifluoroacetate
CAS:<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Fórmula:C24H25BrF4N4O4Cor e Forma:SolidPeso molecular:589.386Paederosidic acid
CAS:<p>Paederosidic acid shows anti-tumor, anticonvulsant, and sedative properties, may treat epilepsy by modulating brain GABA and glutamate levels.</p>Fórmula:C18H24O12SPureza:98% - 99.56%Cor e Forma:SolidPeso molecular:464.44Thalidomide-O-amido-PEG3-C2-NH2 TFA
CAS:<p>Synthetic E3 ligase ligand-linker, Thalidomide-O-amido-PEG3-C2-NH2 TFA, used in PROTAC with cereblon ligand and PEG.</p>Fórmula:C25H31F3N4O11Pureza:99.82%Cor e Forma:SolidPeso molecular:620.54OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Fórmula:C29H32F3N5O3Pureza:97.07% - 99.93%Cor e Forma:SolidPeso molecular:555.59Quizartinib
CAS:<p>Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.</p>Fórmula:C29H32N6O4SPureza:98% - 99.42%Cor e Forma:SolidPeso molecular:560.67Sulindac sodium
CAS:<p>Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.</p>Fórmula:C20H16FNaO3SCor e Forma:SolidPeso molecular:378.39Parcetasal
CAS:<p>Parcetasal (MR-897) is a non-steroidal anti-inflammatory agent that can be used in pain relief studies.</p>Fórmula:C17H15NO5Pureza:99.07%Cor e Forma:SolidPeso molecular:313.3Quinidine sulfate dihydrate
CAS:<p>Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor</p>Fórmula:C40H54N4O10SPureza:99.85%Cor e Forma:White To Light Yellow Crystal PowdePeso molecular:782.9LDN-57444
CAS:<p>LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .</p>Fórmula:C17H11Cl3N2O3Pureza:97.8% - 99.87%Cor e Forma:SolidPeso molecular:397.64Sepantronium bromide
CAS:<p>Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.</p>Fórmula:C20H19BrN4O3Pureza:99.68% - 99.85%Cor e Forma:SolidPeso molecular:443.26Tandutinib
CAS:<p>Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3</p>Fórmula:C31H42N6O4Pureza:99.45% - ≥98%Cor e Forma:White SolidPeso molecular:562.7Navtemadlin
CAS:<p>Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.</p>Fórmula:C28H35Cl2NO5SPureza:95.55% - 99.08%Cor e Forma:SolidPeso molecular:568.55LY-411575
CAS:<p>LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage.</p>Fórmula:C26H23F2N3O4Pureza:97.03% - 99.38%Cor e Forma:SolidPeso molecular:479.48Etretinate
CAS:<p>Etretinate (Ro 10-9359), an oral retinoid, treats psoriasis by promoting cell differentiation and reducing cell growth and inflammation.</p>Fórmula:C23H30O3Pureza:97.89%Cor e Forma:Crystals Crystalline SolidPeso molecular:354.48Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Cor e Forma:SolidPeso molecular:718.08SKI-178
CAS:<p>SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.</p>Fórmula:C21H22N4O4Pureza:97.09%Cor e Forma:SolidPeso molecular:394.42Pinosylvin
CAS:<p>Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.</p>Fórmula:C14H12O2Pureza:99.89% - 99.91%Cor e Forma:SolidPeso molecular:212.24PF-3758309 dihydrochloride
<p>PF-3758309 dihydrochloride is a potent PAK4 inhibitor (Kd = 2.7 nM, Ki = 18.7 nM), oral, ATP-competitive; blocks cell growth, induces apoptosis.</p>Fórmula:C25H32Cl2N8OSCor e Forma:SolidPeso molecular:563.55Sacubitril/Valsartan
CAS:<p>Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for treatment of hypertension and heart failure.</p>Fórmula:C48H55N6O8Na3·5H2OPureza:99.75% - >99.99%Cor e Forma:SolidPeso molecular:957.99LCL161
CAS:<p>LCL161 is a SMAC mimetic, an IAP antagonist with oral activity that inhibits XIAP and cIAP1. LCL161 has potential antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C26H33FN4O3SPureza:99.13% - 99.87%Cor e Forma:SolidPeso molecular:500.63Capmatinib 2HCl.H2O
CAS:<p>Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.</p>Fórmula:C23H21Cl2FN6O2Pureza:99.77%Cor e Forma:SolidPeso molecular:503.36PRLX-93936
CAS:<p>PRLX-93936 is a selective Ras pathway protein inhibitor that modulates RAS/JNK pathway-associated protein phosphorylation, anticancer activity.</p>Fórmula:C21H24N4O2Cor e Forma:SolidPeso molecular:364.44Elevenostat
CAS:<p>Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.</p>Fórmula:C16H17N3O4Pureza:95% - 96.14%Cor e Forma:SolidPeso molecular:315.324-IBP
CAS:<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Fórmula:C19H21IN2OPureza:98.99%Cor e Forma:SolidPeso molecular:420.29Alogliptin Benzoate
CAS:<p>Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.</p>Fórmula:C25H27N5O4Pureza:99.94% - >99.99%Cor e Forma:White PowderPeso molecular:461.51Niraparib tosylate monohyrate
CAS:<p>Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.</p>Fórmula:C26H30N4O5SPureza:97.7% - 98.41%Cor e Forma:SolidPeso molecular:510.61
