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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"

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  • BRD4 Inhibitor-40
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    BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Fórmula:C27H32N8O
    Cor e Forma:Solid
    Peso molecular:484.596

    Ref: TM-T205510

  • KI-CDK9d-32
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Fórmula:C39H45N9O4
    Cor e Forma:Solid
    Peso molecular:703.83

    Ref: TM-T207184

  • 5'-DMT-5-F-2'-dU Phosphoramidite
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    5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    <p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>
    Fórmula:C39H46FN4O8P
    Cor e Forma:Solid
    Peso molecular:748.777

    Ref: TM-T206476

  • Haspin-IN-2
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    Haspin-IN-2

    CAS:
    <p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>
    Fórmula:C12H8N4O3
    Cor e Forma:Solid
    Peso molecular:256.22

    Ref: TM-T60394

  • Terpendole E
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    Terpendole E

    CAS:
    <p>Terpendole E is an atypical L5 site inhibitor.</p>
    Fórmula:C28H39NO3
    Cor e Forma:Solid
    Peso molecular:437.61

    Ref: TM-T70289

  • 6-B345TTQ
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    6-B345TTQ

    CAS:
    <p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>
    Fórmula:C22H20BrNO4
    Cor e Forma:Solid
    Peso molecular:442.303

    Ref: TM-T204244

  • Glycyl H-1152 hydrochloride
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    Glycyl H-1152 hydrochloride

    CAS:
    <p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>
    Fórmula:C18H26Cl2N4O3S
    Cor e Forma:Solid
    Peso molecular:449.39

    Ref: TM-T35459

  • Logotipo do CymitQuimica
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    Anticancer agent 29

    <p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>
    Fórmula:C22H15ClFNO
    Cor e Forma:Solid
    Peso molecular:363.81

    Ref: TM-T61378

  • Logotipo do CymitQuimica
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    Dyrk1A/α-synuclein-IN-2

    <p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>
    Fórmula:C21H16N4O4S
    Cor e Forma:Solid
    Peso molecular:420.44

    Ref: TM-T62226

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Fórmula:C25H30FN7O
    Cor e Forma:Solid
    Peso molecular:463.55

    Ref: TM-T205073

  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    <p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>
    Fórmula:C25H23N3O3S
    Cor e Forma:Solid
    Peso molecular:445.53

    Ref: TM-T200918

  • HNC-1664
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    HNC-1664

    CAS:
    <p>HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.</p>
    Fórmula:C12H13FIN3O3
    Cor e Forma:Solid
    Peso molecular:393.153

    Ref: TM-T205157

  • CDK9 autophagic degrader 1
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    CDK9 autophagic degrader 1

    CAS:
    <p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>
    Fórmula:C34H39N7O4S2
    Cor e Forma:Solid
    Peso molecular:673.848

    Ref: TM-T204672

  • LNA-GMP
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    LNA-GMP

    CAS:
    <p>LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C11H14N5O8P
    Cor e Forma:Solid
    Peso molecular:375.23

    Ref: TM-TSW-00965

  • CIB-L43
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    CIB-L43

    CAS:
    <p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>
    Fórmula:C15H16N2O3S
    Pureza:99.64%
    Cor e Forma:Solid
    Peso molecular:304.36

    Ref: TM-T205607

  • IXA62
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    IXA62

    CAS:
    <p>IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.</p>
    Fórmula:C24H23N3O3
    Cor e Forma:Solid
    Peso molecular:401.458

    Ref: TM-T206732

  • CDK2-IN-31
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    CDK2-IN-31

    CAS:
    <p>CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.</p>
    Fórmula:C37H52N6O5
    Cor e Forma:Solid
    Peso molecular:660.85

    Ref: TM-T201156

  • Logotipo do CymitQuimica
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    IRE1α kinase-IN-5

    <p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>
    Fórmula:C28H30N6O3S
    Cor e Forma:Solid
    Peso molecular:530.64

    Ref: TM-T63734

  • KL-50
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    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Fórmula:C7H7FN6O2
    Cor e Forma:Solid
    Peso molecular:226.17

    Ref: TM-T200136

  • Logotipo do CymitQuimica
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    DNA Gyrase-IN-1

    <p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>
    Fórmula:C24H24FN7O6
    Cor e Forma:Solid
    Peso molecular:525.49

    Ref: TM-T63681