CymitQuimica logo
Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

Exibir 10 mais subcategorias

Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
produtos por página.
  • Zeltociclib
    Targetmol
    + Info

    Zeltociclib

    CAS:
    <p>Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.</p>
    Fórmula:C18H20F3N4O2P
    Cor e Forma:Solid
    Peso molecular:412.346

    Ref: TM-T205641

  • Ladirubicin
    Targetmol
    + Info

    Ladirubicin

    CAS:
    <p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>
    Fórmula:C29H31NO11S
    Cor e Forma:Solid
    Peso molecular:601.62

    Ref: TM-T32534

  • TY-011
    Targetmol
    + Info

    TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Fórmula:C18H16ClN5
    Cor e Forma:Solid
    Peso molecular:337.81

    Ref: TM-T89833

  • 2'-(2-Nitrobenzyl)-ATP
    Targetmol
    + Info

    2'-(2-Nitrobenzyl)-ATP

    CAS:
    <p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>
    Fórmula:C17H21N6O15P3
    Cor e Forma:Solid
    Peso molecular:642.30

    Ref: TM-T207643

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    c-Myc inhibitor 4

    <p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>
    Fórmula:C26H33FN6O3
    Cor e Forma:Solid
    Peso molecular:496.58

    Ref: TM-T63359

  • GTSE1-IN-1
    Targetmol
    + Info

    GTSE1-IN-1

    CAS:
    <p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>
    Fórmula:C21H24FN7
    Cor e Forma:Solid
    Peso molecular:393.46

    Ref: TM-T200127

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    CDK/HDAC-IN-1

    <p>CDK/HDAC-IN-1 inhibits CDK2/4/6 &amp; HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.</p>
    Fórmula:C20H18N4O4
    Cor e Forma:Solid
    Peso molecular:378.38

    Ref: TM-T61583

  • PD-L1-IN-7
    Targetmol
    + Info

    PD-L1-IN-7

    CAS:
    <p>PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.</p>
    Fórmula:C46H50N6O7
    Cor e Forma:Solid
    Peso molecular:798.93

    Ref: TM-T89952

  • HPH-15
    Targetmol
    + Info

    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Fórmula:C19H31N3S4
    Cor e Forma:Solid
    Peso molecular:429.73

    Ref: TM-T205327

  • (E)-Antiviral agent 67
    Targetmol
    + Info

    (E)-Antiviral agent 67

    CAS:
    <p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>
    Fórmula:C19H19N3O
    Cor e Forma:Solid
    Peso molecular:305.374

    Ref: TM-T206106

  • TREX1-IN-3
    Targetmol
    + Info

    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Fórmula:C24H19ClN6O4
    Cor e Forma:Solid
    Peso molecular:490.898

    Ref: TM-T205254

  • SCH-1473759
    Targetmol
    + Info

    SCH-1473759

    CAS:
    <p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>
    Fórmula:C20H26N8OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:426.54

    Ref: TM-T16862

  • SR121566A
    Targetmol
    + Info

    SR121566A

    CAS:
    <p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>
    Fórmula:C20H25N5O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:431.51

    Ref: TM-T12999

  • Epolactaene
    Targetmol
    + Info

    Epolactaene

    CAS:
    <p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases &amp; human DNA topoisomerase II.</p>
    Fórmula:C21H27NO6
    Cor e Forma:Solid
    Peso molecular:389.44

    Ref: TM-T70284

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    Dyrk1A-IN-1

    <p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>
    Fórmula:C23H20N4O3S
    Cor e Forma:Solid
    Peso molecular:432.49

    Ref: TM-T62414

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    CDK2-IN-8

    <p>CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.</p>
    Fórmula:C22H25N5O3
    Cor e Forma:Solid
    Peso molecular:407.47

    Ref: TM-T62038

  • Cdc7-IN-11
    Targetmol
    + Info

    Cdc7-IN-11

    CAS:
    <p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>
    Fórmula:C20H22F2N4O2S
    Cor e Forma:Solid
    Peso molecular:420.48

    Ref: TM-T62231

  • MU147
    Targetmol
    + Info

    MU147

    CAS:
    <p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>
    Fórmula:C19H13N3O3S
    Cor e Forma:Solid
    Peso molecular:363.39

    Ref: TM-T205293

  • CDK2-IN-40
    Targetmol
    + Info

    CDK2-IN-40

    CAS:
    <p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>
    Fórmula:C16H21N7O2
    Cor e Forma:Solid
    Peso molecular:343.384

    Ref: TM-T205452

  • Logotipo do CymitQuimica
    Targetmol
    + Info

    FT3967385

    <p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>
    Fórmula:C21H19N5O2
    Cor e Forma:Solid
    Peso molecular:373.41

    Ref: TM-T61512