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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

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  • CLK1/2-IN-1
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    CLK1/2-IN-1

    CAS:
    <p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>
    Fórmula:C21H20F3N7O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:443.42

    Ref: TM-T23896

  • Logotipo do CymitQuimica
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    CDK8-IN-11 hydrochloride

    <p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>
    Fórmula:C19H16ClF3N4O2
    Cor e Forma:Solid
    Peso molecular:424.8

    Ref: TM-T62293

  • p38α inhibitor 9
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    p38α inhibitor 9

    CAS:
    <p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>
    Fórmula:C27H24FN3O3
    Cor e Forma:Solid
    Peso molecular:457.496

    Ref: TM-T206722

  • USP7-IN-10
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    USP7-IN-10

    CAS:
    <p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>
    Fórmula:C26H29ClN4O3S
    Cor e Forma:Solid
    Peso molecular:513.05

    Ref: TM-T73136

  • L-I-OddU
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    L-I-OddU

    CAS:
    <p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>
    Fórmula:C8H9IN2O5
    Cor e Forma:Solid
    Peso molecular:340.07

    Ref: TM-T61080

  • FT709
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    FT709

    CAS:
    <p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>
    Fórmula:C23H22N4O7S
    Cor e Forma:Solid
    Peso molecular:498.51

    Ref: TM-T63375

  • SF0166
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    SF0166

    CAS:
    <p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>
    Fórmula:C23H27F2N5O4
    Cor e Forma:Solid
    Peso molecular:475.49

    Ref: TM-T70368

  • LN-439A
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    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Fórmula:C24H26FN3O4
    Cor e Forma:Solid
    Peso molecular:439.48

    Ref: TM-T200435

  • DNA polymerase-IN-6
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    DNA polymerase-IN-6

    CAS:
    <p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>
    Fórmula:C26H28ClFN8O4
    Cor e Forma:Solid
    Peso molecular:571.003

    Ref: TM-T204284

  • Logotipo do CymitQuimica
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    CDK1-IN-3

    <p>CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.</p>
    Fórmula:C28H25ClF3N5O2
    Cor e Forma:Solid
    Peso molecular:555.98

    Ref: TM-T63933

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Fórmula:C26H27Cl2N3O
    Cor e Forma:Solid
    Peso molecular:468.42

    Ref: TM-T200443

  • WRN inhibitor 13
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    WRN inhibitor 13

    CAS:
    <p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>
    Fórmula:C16H20N2O5S
    Cor e Forma:Solid
    Peso molecular:352.405

    Ref: TM-T204389

  • PD-1-IN-17
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    PD-1-IN-17

    CAS:
    <p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>
    Fórmula:C13H22N6O7
    Pureza:99.6%
    Cor e Forma:Solid
    Peso molecular:374.35

    Ref: TM-T12377

  • LIMK1 inhibitor 1
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    LIMK1 inhibitor 1

    CAS:
    <p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>
    Fórmula:C12H15N3S2
    Cor e Forma:Solid
    Peso molecular:265.398

    Ref: TM-T204784

  • Logotipo do CymitQuimica
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    DNA Gyrase-IN-1

    <p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>
    Fórmula:C24H24FN7O6
    Cor e Forma:Solid
    Peso molecular:525.49

    Ref: TM-T63681

  • GR 83895
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    GR 83895

    CAS:
    <p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>
    Fórmula:C29H39N9O8S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:673.74

    Ref: TM-T25460

  • 5'-DMT-5-F-2'-dU Phosphoramidite
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    5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    <p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>
    Fórmula:C39H46FN4O8P
    Cor e Forma:Solid
    Peso molecular:748.777

    Ref: TM-T206476

  • CDK9 autophagic degrader 1
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    CDK9 autophagic degrader 1

    CAS:
    <p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>
    Fórmula:C34H39N7O4S2
    Cor e Forma:Solid
    Peso molecular:673.848

    Ref: TM-T204672

  • KL-50
    Targetmol
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    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Fórmula:C7H7FN6O2
    Cor e Forma:Solid
    Peso molecular:226.17

    Ref: TM-T200136

  • LNA-GDP
    Targetmol
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    LNA-GDP

    CAS:
    <p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C11H15N5O11P2
    Cor e Forma:Solid
    Peso molecular:455.21

    Ref: TM-TSW-00961