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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

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  • CDK9-IN-38
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    CDK9-IN-38

    CAS:
    <p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>
    Fórmula:C22H23N5O3S
    Cor e Forma:Solid
    Peso molecular:437.515

    Ref: TM-T206913

  • CDK6-IN-1
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    CDK6-IN-1

    CAS:
    <p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>
    Fórmula:C30H23N5
    Cor e Forma:Solid
    Peso molecular:453.54

    Ref: TM-T201591

  • N-Isobutyryl-2', 3'-acetyl-guanosine
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    N-Isobutyryl-2', 3'-acetyl-guanosine

    CAS:
    <p>N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.</p>
    Fórmula:C18H23N5O8
    Cor e Forma:Solid
    Peso molecular:437.404

    Ref: TM-T206416

  • Logotipo do CymitQuimica
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    CYP2C19-IN-1

    <p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>
    Fórmula:C26H26N2O6S
    Cor e Forma:Solid
    Peso molecular:494.56

    Ref: TM-T63337

  • CDK7-IN-31
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    CDK7-IN-31

    CAS:
    <p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>
    Fórmula:C27H32F5N6O2P
    Cor e Forma:Solid
    Peso molecular:598.55

    Ref: TM-T201665

  • T-2513 hydrochloride
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    T-2513 hydrochloride

    CAS:
    <p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>
    Fórmula:C25H28ClN3O5
    Cor e Forma:Solid
    Peso molecular:485.96

    Ref: TM-T63225

  • CHK-IN-1
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    CHK-IN-1

    CAS:
    <p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>
    Fórmula:C18H19ClFN5OS
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:407.89

    Ref: TM-T13148

  • Logotipo do CymitQuimica
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    Hesperadin hydrochloride

    <p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>
    Fórmula:C29H33ClN4O3S
    Cor e Forma:Solid
    Peso molecular:553.12

    Ref: TM-T63905

  • LNA-AMP
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    LNA-AMP

    CAS:
    <p>LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.</p>
    Fórmula:C11H14N5O7P
    Cor e Forma:Solid
    Peso molecular:359.23

    Ref: TM-TSW-00964

  • CDK1-IN-7
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    CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Fórmula:C23H19ClN4O3
    Cor e Forma:Solid
    Peso molecular:434.88

    Ref: TM-T207488

  • Logotipo do CymitQuimica
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    CDK8-IN-9

    <p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>
    Cor e Forma:Solid

    Ref: TM-T64245

  • Logotipo do CymitQuimica
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    Dyrk1A-IN-2

    <p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>
    Fórmula:C27H32N6O4
    Cor e Forma:Solid
    Peso molecular:504.58

    Ref: TM-T63440

  • Dmf-dg
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    Dmf-dg

    CAS:
    <p>Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.</p>
    Fórmula:C13H18N6O4
    Cor e Forma:Solid
    Peso molecular:322.32

    Ref: TM-TSW-00950

  • UMPK ligand 1
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    UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Fórmula:C15H22N4O5S
    Cor e Forma:Solid
    Peso molecular:370.424

    Ref: TM-T204579

  • 2'-F-CDP
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    2'-F-CDP

    CAS:
    <p>2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C9H14FN3O10P2
    Cor e Forma:Solid
    Peso molecular:405.17

    Ref: TM-TSW-00957

  • β-catenin-IN-8
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    β-catenin-IN-8

    CAS:
    <p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>
    Fórmula:C15H12ClN3O2S
    Cor e Forma:Solid
    Peso molecular:333.79

    Ref: TM-T201581

  • PLK1-IN-5
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    PLK1-IN-5

    CAS:
    <p>PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].</p>
    Fórmula:C28H39N7O3
    Cor e Forma:Solid
    Peso molecular:521.65

    Ref: TM-T87222

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    <p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>
    Fórmula:C26H25FN8O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:532.53

    Ref: TM-T12674

  • INX-315
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    INX-315

    CAS:
    <p>INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.</p>
    Fórmula:C19H21N7O3S
    Pureza:99.88%
    Cor e Forma:Solid
    Peso molecular:427.48

    Ref: TM-T86723

  • Dyrk1A-IN-8
    Targetmol
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    Dyrk1A-IN-8

    CAS:
    <p>Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.</p>
    Fórmula:C17H21N3O
    Cor e Forma:Solid
    Peso molecular:283.37

    Ref: TM-T87614