Chk
Os inibidores da quinase de checkpoint (Chk) têm como alvo as quinasas Chk1 e Chk2, que são reguladoras-chave da resposta aos danos no DNA e dos pontos de verificação do ciclo celular. Essas quinasas interrompem a progressão do ciclo celular em resposta a danos no DNA, permitindo tempo para reparo. Inibir as quinasas Chk pode impedir a parada do ciclo celular, forçando as células danificadas a prosseguir no ciclo e, eventualmente, sofrer apoptose. Os inibidores de Chk são particularmente valiosos na pesquisa do câncer, onde podem sensibilizar as células tumorais a agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma variedade de inibidores de Chk de alta qualidade para apoiar sua pesquisa em resposta a danos no DNA, regulação do ciclo celular e oncologia.
Foram encontrados 42 produtos de "Chk"
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CHK1-IN-4 hydrochloride
<p>CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).</p>Fórmula:C18H19BrClN7O2Pureza:99.29%Cor e Forma:SoildPeso molecular:480.75Monalizumab
CAS:<p>Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.</p>Pureza:95% - > 95%Cor e Forma:LiquidPeso molecular:147 kDa (average)WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Fórmula:C17H12N2O2SPureza:98.40%Cor e Forma:SolidPeso molecular:308.35CBP501 Affinity Peptide
CAS:<p>CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].</p>Fórmula:C68H119N21O25SCor e Forma:SolidPeso molecular:1662.86Zimistobart
CAS:<p>Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:LiquidCCT241533 dihydrochloride
CAS:<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Fórmula:C23H29Cl2FN4O4Cor e Forma:SolidPeso molecular:515.41Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Fórmula:C16H18F3N7Cor e Forma:SolidPeso molecular:365.364CHK1-IN-12
<p>CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.</p>Fórmula:C19H19N7O2Cor e Forma:SolidPeso molecular:377.16002CHK1-IN-9
<p>CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.</p>CCT244747
CAS:<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>Fórmula:C20H24N8O2Pureza:99.17%Cor e Forma:SolidPeso molecular:408.46GDC-0425
CAS:<p>GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.</p>Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38GDC-0575 dihydrochloride
CAS:<p>GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.</p>Fórmula:C16H22BrCl2N5OCor e Forma:SolidPeso molecular:451.19LY2880070
CAS:<p>LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.</p>Fórmula:C19H23N7O2Pureza:99.77%Cor e Forma:SolidPeso molecular:381.43GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Fórmula:C16H20BrN5OPureza:≥95%Cor e Forma:SolidPeso molecular:378.27SCH900776
CAS:<p>SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.</p>Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Cor e Forma:SolidPeso molecular:376.25GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Fórmula:C16H21BrClN5OPureza:97.85%Cor e Forma:SolidPeso molecular:414.73SAR-020106
CAS:<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>Fórmula:C19H19ClN6OPureza:97.78%Cor e Forma:SolidPeso molecular:382.85Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Cor e Forma:SolidPeso molecular:436.3CCT245737
CAS:<p>CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.</p>Fórmula:C16H16F3N7OPureza:98.06% - 99.69%Cor e Forma:SolidPeso molecular:379.34AZD-7762
CAS:<p>AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.</p>Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Cor e Forma:SolidPeso molecular:362.42AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.88PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Cor e Forma:SolidPeso molecular:580.66PV-1019
CAS:<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Fórmula:C18H17N7O3Cor e Forma:SolidPeso molecular:379.37VRX-0466617
CAS:<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Fórmula:C19H20BrN5O2SCor e Forma:SolidPeso molecular:462.36TCS 2312
CAS:<p>checkpoint kinase 1 (chk1) inhibitor</p>Fórmula:C25H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:412.48SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Cor e Forma:SolidPeso molecular:295.3M443
CAS:<p>M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.</p>Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:SolidPeso molecular:589.61NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:SolidPeso molecular:419.45CHK1-IN-3
CAS:<p>CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).</p>Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46CCT241533 hydrochloride
CAS:<p>CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H28ClFN4O4Pureza:97.13%Cor e Forma:SolidPeso molecular:478.95MU-380
CAS:<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23CCT241533
CAS:<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48VER-00158411
CAS:<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64CHK1-IN-2
CAS:<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Fórmula:C18H18BrN7O2Pureza:98%Cor e Forma:SolidPeso molecular:444.29CHK-IN-1
CAS:<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Fórmula:C18H19ClFN5OSPureza:>99.99%Cor e Forma:SolidPeso molecular:407.89BBI-355
CAS:<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Fórmula:C19H19N7O2Cor e Forma:SolidPeso molecular:377.40CHK1-IN-11
CAS:<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Fórmula:C20H22N8O2Cor e Forma:SolidPeso molecular:406.44CHK1 inhibitor
CAS:<p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>Fórmula:C17H21BrN4OPureza:98%Cor e Forma:SolidPeso molecular:377.28Chk1-IN-5
CAS:<p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>Fórmula:C18H18FN7O2Cor e Forma:SolidPeso molecular:383.38PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Fórmula:C19H19FN4O2SPureza:99.4%Cor e Forma:SolidPeso molecular:386.44
