Ferroptose
A ferroptose é uma forma de morte celular regulada caracterizada pelo acúmulo de peróxidos lipídicos e estresse oxidativo dependente de ferro. Ao contrário da apoptose, a ferroptose não é impulsionada por caspases, mas pelo fracasso das defesas antioxidantes celulares, levando à morte celular. Inibidores e indutores de ferroptose são críticos para estudar essa via única de morte celular, que está implicada em várias doenças, incluindo câncer, neurodegeneração e lesão por isquemia-reperfusão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de ferroptose de alta qualidade para apoiar sua pesquisa em mecanismos de morte celular, estresse oxidativo e patologia de doenças.
Foram encontrados 215 produtos de "Ferroptose"
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Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Fórmula:C26H23N5OCor e Forma:SolidPeso molecular:421.49W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Fórmula:C25H20F3N5O6Pureza:98.1%Cor e Forma:SolidPeso molecular:543.45PRLX-93936 HCL
CAS:<p>PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.</p>Fórmula:C21H26Cl2N4O2Pureza:98.4% - 99.94%Cor e Forma:SolidPeso molecular:437.3784-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Fórmula:C25H22F3NO5Pureza:99.76%Cor e Forma:SolidPeso molecular:473.44CuATSM
CAS:<p>Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.</p>Fórmula:C8H14CuN6S2Cor e Forma:SolidPeso molecular:321.92Idebenone
CAS:Fórmula:C19H30O5Pureza:>98.0%(T)(HPLC)Cor e Forma:Light yellow to Brown powder to crystalPeso molecular:338.44CuATSP
CAS:<p>CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.</p>Fórmula:C18H18CuN6S2Pureza:97.09%Cor e Forma:SolidPeso molecular:446.05Cerivastatin sodium
CAS:<p>Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.</p>Fórmula:C26H33FNNaO5Pureza:98.50% - 99.67%Cor e Forma:SolidPeso molecular:481.53CCW16
CAS:<p>CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.</p>Fórmula:C22H20ClNO3Pureza:97%Cor e Forma:SolidPeso molecular:381.85Chrysosplenetin
CAS:<p>Chrysosplenetin is a metabolic inhibitor of artemisinin.</p>Fórmula:C19H18O8Pureza:97.43% - 98.4%Cor e Forma:SolidPeso molecular:374.34L-Glutamic acid monosodium salt
CAS:<p>L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.</p>Fórmula:C5H8NO4·NaPureza:99.93%Cor e Forma:White Solid CrystallinePeso molecular:169.11Piperlongumine
CAS:<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Fórmula:C17H19NO5Pureza:97.03% - 99.90%Cor e Forma:SolidPeso molecular:317.34NADPH tetracyclohexanamine
CAS:<p>NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.</p>Fórmula:C45H82N11O17P3Pureza:98.73% - 99.05%Cor e Forma:SolidPeso molecular:1142.12L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS:<p>L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.</p>Fórmula:C8H18N2O3SPureza:97.07% - ≥98%Cor e Forma:White Fine PowderPeso molecular:222.31ML-210
CAS:<p>ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.</p>Fórmula:C22H20Cl2N4O4Pureza:97% - 99.03%Cor e Forma:SolidPeso molecular:475.32Piperazine Erastin
CAS:<p>Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.</p>Fórmula:C35H41ClN6O4Pureza:99.52%Cor e Forma:SolidPeso molecular:645.19RSL3
CAS:<p>View and buy RSL3 from TargetMol.RSL3 is a VDAC-independent ferroptosis activator.Cited in 10 publications.</p>Fórmula:C23H21ClN2O5Pureza:98% - 99.96%Cor e Forma:SolidPeso molecular:440.88TBHQ
CAS:<p>TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.</p>Fórmula:C10H14O2Pureza:99.17% - 99.53%Cor e Forma:White Solid PowderPeso molecular:166.22Trolox
CAS:<p>Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.</p>Fórmula:C14H18O4Pureza:98.90% - 99.90%Cor e Forma:White To Fainly Beige Crystalline PowderPeso molecular:250.29Alogliptin
CAS:<p>Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9</p>Fórmula:C18H21N5O2Pureza:99.63%Cor e Forma:SolidPeso molecular:339.39
