Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46PNZ5
CAS:<p>PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation</p>Fórmula:C20H18N2O2Pureza:99.51% - 99.61%Cor e Forma:SolidPeso molecular:318.37KBH-A42
CAS:<p>KBH-A42 is an inhibitor of histone deacetylase.</p>Fórmula:C17H22N2O3Pureza:98%Cor e Forma:SolidPeso molecular:302.37JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Fórmula:C25H28N8OPureza:97.89%Cor e Forma:SolidPeso molecular:456.54DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Fórmula:C15H23N7O4SPureza:98%Cor e Forma:SolidPeso molecular:397.45JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Fórmula:C20H18FN5O3SPureza:99.53%Cor e Forma:SolidPeso molecular:427.45(2R/S)-6-PNG
CAS:<p>(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.</p>Fórmula:C20H20O5Pureza:98%Cor e Forma:SolidPeso molecular:340.37SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Cor e Forma:SolidPeso molecular:378.79SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Fórmula:C20H23N7OPureza:99.70%Cor e Forma:SolidPeso molecular:377.44KP-302
CAS:<p>KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.</p>Fórmula:C20H23N5O2Pureza:99.77%Cor e Forma:SolidPeso molecular:365.43JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Fórmula:C20H18ClN7OPureza:98%Cor e Forma:SolidPeso molecular:407.86Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Fórmula:C33H42ClN3O7SPureza:98%Cor e Forma:SolidPeso molecular:660.22BET-IN-7
CAS:<p>BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.</p>Fórmula:C18H12ClN3OSCor e Forma:SolidPeso molecular:353.83Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Fórmula:C18H16N4OPureza:98%Cor e Forma:SolidPeso molecular:304.35GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Cor e Forma:SolidPeso molecular:348.33Ilorasertib hydrochloride
CAS:<p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>Fórmula:C25H22ClFN6O2SPureza:98.45%Cor e Forma:SolidPeso molecular:525JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Fórmula:C19H15FN4OPureza:98.27%Cor e Forma:SolidPeso molecular:334.35Aurora kinase inhibitor-10
CAS:<p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>Fórmula:C21H19F5N6O4SCor e Forma:SolidPeso molecular:546.47MT477
CAS:<p>MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.</p>Fórmula:C31H30N2O12S3Cor e Forma:SolidPeso molecular:718.77Rucaparib camsylate
CAS:<p>Rucaparib camsylate, a PARP-1, -2, -3 inhibitor (Ki=1.4 nM for PARP-1) & H6PD blocker, may treat resistant prostate cancer.</p>Fórmula:C19H18FN3O·xC10H16O4SCor e Forma:SolidHIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Fórmula:C17H15N5O3SCor e Forma:SolidPeso molecular:369.4dWIZ-1
CAS:<p>dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader tha induction of haemoglobin fetalis (HbF) in erythroblasts, sickle cell disease (SCD).</p>Fórmula:C22H29N3O4Pureza:92.87% - 92.87%Cor e Forma:SolidPeso molecular:399.48Y08284
CAS:<p>Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.</p>Fórmula:C26H25FN4O4Cor e Forma:SolidPeso molecular:476.5HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SCor e Forma:SolidPeso molecular:342.35Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23Bizine
CAS:<p>Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.</p>Fórmula:C18H23N3OCor e Forma:SolidPeso molecular:297.39Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07HDAC3-IN-T247
CAS:<p>HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.</p>Fórmula:C21H19N5OSPureza:98.11% - 98.94%Cor e Forma:SolidPeso molecular:389.47SIRT1-IN-2
CAS:<p>SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].</p>Fórmula:C13H15ClN2OCor e Forma:SolidPeso molecular:250.72IDO1 and HDAC1 Inhibitor
CAS:<p>IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).</p>Fórmula:C25H22BrFN8O4Pureza:98%Cor e Forma:SolidPeso molecular:597.4HDAC-IN-49
<p>HDAC-IN-49: potent, broad HDAC inhibitor; IC50s: 10-1880 nM for HDAC1-6; strong anti-leukemic, low toxicity to healthy cells.</p>Fórmula:C26H27FN4O4Cor e Forma:SolidPeso molecular:478.52CYP51/HDAC-IN-1
CAS:<p>Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.</p>Fórmula:C30H40F2N6O4Cor e Forma:SolidPeso molecular:586.67TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Cor e Forma:SolidPeso molecular:288.22Sirt1/2-IN-1
CAS:<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Fórmula:C22H13ClN2OS2Cor e Forma:SolidPeso molecular:420.93HDAC6-IN-15
<p>HDAC6-IN-15: selective HDAC6 inhibitor, IC50 of 38.2 nM, for cancer and neurodegenerative research.</p>Fórmula:C25H28FFeN3O2Cor e Forma:SolidPeso molecular:477.35M133
CAS:<p>M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Fórmula:C23H24N4OS2Cor e Forma:SolidPeso molecular:436.59CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Fórmula:C10H10N2O4Cor e Forma:SolidPeso molecular:222.2Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Fórmula:C18H23BrN4O2Cor e Forma:SolidPeso molecular:407.312PIM-1 Inhibitor 2
CAS:<p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75MI-2-2
CAS:<p>MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.</p>Fórmula:C17H20F3N5S2Pureza:99.65%Cor e Forma:SolidPeso molecular:415.5OUL245
CAS:<p>OUL245: A selective PARP2 inhibitor (IC50=44nM), also inhibits other PARPs/TNKS (IC50=2.9-8.8μM).</p>Fórmula:C8H5N3OSCor e Forma:SolidPeso molecular:191.21YM-53601
CAS:<p>YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.</p>Fórmula:C21H22ClFN2OPureza:99.65%Cor e Forma:SolidPeso molecular:372.86IACS-9571
CAS:<p>IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).</p>Fórmula:C32H42N4O8SPureza:98%Cor e Forma:SolidPeso molecular:642.76Tyk2-IN-5
CAS:<p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>Fórmula:C21H19FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:434.43CPI703
CAS:<p>CPI703 is a novel potent and specific CBP/EP300 bromodomain inhibitor.</p>Fórmula:C17H22N4OPureza:98%Cor e Forma:SolidPeso molecular:298.38JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Cor e Forma:SolidPeso molecular:476.57Bromodomain IN-1
CAS:<p>Bromodomain IN-1 is an inhibitor of Bromodomain.</p>Fórmula:C22H23ClN4O3SPureza:98%Cor e Forma:SolidPeso molecular:458.962′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Fórmula:C9H12N4O6Cor e Forma:SolidPeso molecular:272.216-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Cor e Forma:SolidPeso molecular:258.23SB-284851-BT
CAS:<p>SB-284851-BT: BRD4/p38α/BRDT inhibitor; IC50: BRD4-BD1 1.7µM, BRDT 18µM, BRD4 3.7µM; Kd p38α 0.47nM; reduces IL-8, affects c-Myc/NF-κB.</p>Fórmula:C26H26FN5OCor e Forma:SolidPeso molecular:443.52BET-BAY 002 (S enantiomer)
CAS:<p>The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).</p>Fórmula:C22H18ClN5OPureza:98%Cor e Forma:SolidPeso molecular:403.86PKC-IN-4
CAS:<p>PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM.</p>Fórmula:C21H25N5SCor e Forma:SolidPeso molecular:379.52CD161
CAS:<p>CD161: powerful, selective oral BET inhibitor; IC50: 28.2 nM (BRD4 BD1), 7.2 nM (BRD4 BD2); strong anticancer properties.</p>Fórmula:C26H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:435.48YF479
CAS:<p>YF479 is an inhibitor of histone deacetylase that acts by inhibiting breast tumor growth, metastasis, and recurrence.</p>Fórmula:C22H27BrN2O5Pureza:98%Cor e Forma:SolidPeso molecular:479.36TC-E 5001
CAS:<p>dual tankyrase (TNKS) inhibitor</p>Fórmula:C20H19N5O3SPureza:98%Cor e Forma:SolidPeso molecular:409.46DC-CPin7
CAS:<p>DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].</p>Fórmula:C19H22N2O5Cor e Forma:SolidPeso molecular:358.39OICR-0547
CAS:<p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>Fórmula:C28H29F3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:542.55HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Fórmula:C15H11N3O4Cor e Forma:SolidPeso molecular:297.27Cercosporamide
CAS:<p>Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.</p>Fórmula:C16H13NO7Pureza:98%Cor e Forma:SolidPeso molecular:331.28Bisindolylmaleimide II
CAS:<p>protein kinase C (PKC) inhibitor</p>Fórmula:C27H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:438.52LSD1-IN-12
CAS:<p>LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B</p>Fórmula:C16H16N2OCor e Forma:SolidPeso molecular:252.31OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Fórmula:C13H14N4O3SCor e Forma:SolidPeso molecular:306.34SRTCX1002
CAS:<p>SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.</p>Fórmula:C21H19N5O2SPureza:98%Cor e Forma:SolidPeso molecular:405.47AMPK activator 6
CAS:<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Fórmula:C25H28O5Cor e Forma:SolidPeso molecular:408.49ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Fórmula:C36H48N6O3Pureza:99.5%Cor e Forma:SolidPeso molecular:612.8PU141
CAS:<p>PU141 is a novel inhibitor of histone acetyltransferase (HAT).</p>Fórmula:C14H9F3N2OSPureza:98%Cor e Forma:SolidPeso molecular:310.29CHIC35
CAS:<p>CHIC-35 is a selective deacetylase SIRT1 inhibitor.</p>Fórmula:C14H15ClN2OCor e Forma:SolidPeso molecular:262.73OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H29Cl4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:573.34GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Fórmula:C42H55NO8Pureza:98%Cor e Forma:SolidPeso molecular:701.89ET-JQ1-OH
CAS:<p>ET-JQ1-OH is an allele-specific BET inhibitor.</p>Fórmula:C21H21ClN4O2SCor e Forma:SolidPeso molecular:428.93SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Fórmula:C26H17ClN2O8SPureza:98.56%Cor e Forma:SolidPeso molecular:552.94MicroRNA-21-IN-2
CAS:<p>MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.</p>Fórmula:C17H15N3O3SPureza:99.2%Cor e Forma:SolidPeso molecular:341.38CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Fórmula:C26H24ClN3O3Pureza:97.46%Cor e Forma:SolidPeso molecular:461.94BAY1238097
CAS:<p>BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.</p>Fórmula:C25H33N5O3Pureza:98.1% - 98.79%Cor e Forma:SolidPeso molecular:451.56EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Fórmula:C18H17ClN2OCor e Forma:SolidPeso molecular:312.79SPV106
CAS:<p>SPV106 is a ligand of lysine acetyltransferases (KATs).</p>Fórmula:C22H40O4Pureza:98%Cor e Forma:SolidPeso molecular:368.55BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Fórmula:C32H26F3N3O7Pureza:98%Cor e Forma:SolidPeso molecular:621.56(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Fórmula:C15H19N5OCor e Forma:SolidPeso molecular:285.34PI3K/Akt/CREB activator 1
CAS:<p>PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.</p>Fórmula:C19H15F4NO3Cor e Forma:SolidPeso molecular:381.32Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Fórmula:C23H22F5N7OCor e Forma:SolidPeso molecular:507.469JAK3-IN-1
CAS:<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Fórmula:C26H30ClN7O2Cor e Forma:SolidPeso molecular:508.02SRTCX1003
CAS:<p>SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.</p>Fórmula:C23H23N5O3SCor e Forma:SolidPeso molecular:449.53Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Fórmula:C20H16F3N3O4Cor e Forma:SolidPeso molecular:419.35PBRM1-BD2-IN-6
CAS:<p>PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.</p>Fórmula:C16H15ClN2OCor e Forma:SolidPeso molecular:286.76CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.37HDAC3 Inhibitor
CAS:<p>HDAC3 inhibitor: allosteric, Ki=0.16 nM, favors HDAC3 over HDAC1/2, targets specific leukemia cells, EC50=36.37-151.7 nM.</p>Fórmula:C20H23N3O2Cor e Forma:SolidPeso molecular:337.42AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Fórmula:C25H21ClN2O6Cor e Forma:SolidPeso molecular:480.9RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SCor e Forma:SolidPeso molecular:465.56SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Fórmula:C28H21N5OSCor e Forma:SolidPeso molecular:475.56SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:SolidPeso molecular:369.39KDM5-C49
CAS:<p>KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.</p>Fórmula:C15H24N4O3Pureza:98%Cor e Forma:SolidPeso molecular:308.38Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Fórmula:C27H24N8OPureza:98%Cor e Forma:SolidPeso molecular:476.53CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Fórmula:C21H22ClN3Pureza:98%Cor e Forma:SolidPeso molecular:351.87UMB-136
CAS:<p>UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.</p>Fórmula:C24H27N5O2Pureza:98%Cor e Forma:SolidPeso molecular:417.5BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Fórmula:C26H25N5O2S2Cor e Forma:SolidPeso molecular:503.64OTS186935
CAS:<p>OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H26ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:463.96
