Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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Decitabine
CAS:<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Cor e Forma:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21Levetiracetam
CAS:<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Fórmula:C8H14N2O2Pureza:99.67% - 99.86%Cor e Forma:White Crystalline PowderPeso molecular:170.21Deferoxamine Mesylate
CAS:<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Fórmula:C26H52N6O11SPureza:94.68% - 99.8%Cor e Forma:SolidPeso molecular:656.79VTP50469
CAS:<p>VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.</p>Fórmula:C32H47FN6O4SPureza:98.31% - 99.55%Cor e Forma:SolidPeso molecular:630.82TRIM24/BRPF1-IN-2
CAS:<p>TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.</p>Fórmula:C20H22N2O4SPureza:98.69% - 99.13%Cor e Forma:SoildPeso molecular:386.47Tulmimetostat
CAS:<p>Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced</p>Fórmula:C28H36ClN3O5SPureza:98.04% - 99.872%Cor e Forma:SolidPeso molecular:562.12Indoprofen
CAS:<p>Indoprofen ((±)-Indoprofe) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C17H15NO3Pureza:99.34%Cor e Forma:SolidPeso molecular:281.31Ilginatinib
CAS:<p>Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.</p>Fórmula:C21H20FN7Pureza:98.4% - 99.01%Cor e Forma:SolidPeso molecular:389.43dAURK-4 hydrochloride
<p>dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Fórmula:C52H53Cl2FN8O12Pureza:99.44%Cor e Forma:SolidPeso molecular:1071.93Nimucitinib
CAS:<p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>Fórmula:C25H26F2N6O2Pureza:98.71%Cor e Forma:SoildPeso molecular:480.51Minocycline hydrochloride
CAS:<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Fórmula:C23H28ClN3O7Pureza:99.28% - >99.99%Cor e Forma:Bright Yellow-Orange Amorphous Solid Crystalline YellowPeso molecular:493.94MAT2A inhibitor 2
CAS:<p>MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).</p>Fórmula:C18H24ClN3O3Pureza:99.52%Cor e Forma:SolidPeso molecular:365.85PKC β pseudosubstrate acetate
<p>PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.</p>Pureza:95.42%Cor e Forma:SoildTAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Fórmula:C28H32N4O3SPureza:99.02% - 99.59%Cor e Forma:SolidPeso molecular:504.64Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Fórmula:C11H15N2O5Pureza:98.82% - 99.58%Cor e Forma:SolidPeso molecular:255.25Diperodon hydrochloride
CAS:<p>Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.</p>Fórmula:C22H28ClN3O4Pureza:99.91%Cor e Forma:SolidPeso molecular:433.935-Azacytidine
CAS:<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Fórmula:C8H12N4O5Pureza:99.31% - 99.79%Cor e Forma:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2Cyproheptadine hydrochloride sesquihydrate
CAS:<p>Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2.</p>Fórmula:C21H24ClNOPureza:99.77% - >99.99%Cor e Forma:White To Slightly Yellowish Crystalline SolidPeso molecular:341.88HIF-2α-IN-2
CAS:<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>Fórmula:C17H13F2NO4SPureza:99.24%Cor e Forma:SolidPeso molecular:365.35Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Fórmula:C9H16N4O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:292.25Roxadustat
CAS:<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>Fórmula:C19H16N2O5Pureza:99% - 99.88%Cor e Forma:SolidPeso molecular:352.34Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Fórmula:C22H24ClNO4Pureza:99.53%Cor e Forma:SolidPeso molecular:401.88Acetaminophen
CAS:<p>Acetaminophen: pain reliever, fever reducer; mild anti-inflammatory. Risks: liver, kidney damage, blood cell effects.</p>Fórmula:C8H9NO2Pureza:99.85% - 99.99%Cor e Forma:Colourless Solid CrystallinePeso molecular:151.16Delgocitinib
CAS:<p>Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.</p>Fórmula:C16H18N6OPureza:99.95%Cor e Forma:SolidPeso molecular:310.35MS402
CAS:<p>MS402 is a novel BD1-selective BET BrD inhibitor.</p>Fórmula:C20H19ClN2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:370.83WDR5-IN-6
CAS:<p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>Fórmula:C13H8Cl2N2O2SPureza:99.69%Cor e Forma:SoildPeso molecular:327.19(R)-CR8
CAS:<p>(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.</p>Fórmula:C24H29N7OPureza:98.41%Cor e Forma:SolidPeso molecular:431.53JAK2 Inhibitor V
CAS:<p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>Fórmula:C23H24N2OPureza:98.36% - 99.15%Cor e Forma:SolidPeso molecular:344.45Glucosamine hydrochloride
CAS:<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>Fórmula:C6H13NO5·HClPureza:99.77%Cor e Forma:White Solid CrystallinePeso molecular:215.63LIN28 inhibitor LI71
CAS:<p>LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.</p>Fórmula:C21H21NO3Pureza:95.88%Cor e Forma:SolidPeso molecular:335.4Diflunisal
CAS:<p>Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.</p>Fórmula:C13H8F2O3Pureza:98.92% - 99.42%Cor e Forma:SolidPeso molecular:250.20DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Fórmula:C25H25N3OPureza:98.95%Cor e Forma:SolidPeso molecular:383.49EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Fórmula:C28H35NO3Pureza:98.36%Cor e Forma:SolidPeso molecular:433.58N6-Cyclohexyladenosine
CAS:<p>N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm.</p>Fórmula:C16H23N5O4Pureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:349.38Albendazole
CAS:<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Fórmula:C12H15N3O2SPureza:98.21% - 98.76%Cor e Forma:Colorless Crystals SolidPeso molecular:265.33Curcumin
CAS:<p>Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.</p>Fórmula:C21H20O6Pureza:95% - 98.98%Cor e Forma:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Peso molecular:368.3799EML 425
CAS:<p>EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).</p>Fórmula:C27H24N2O4Pureza:97.6%Cor e Forma:SolidPeso molecular:440.49Histone Acetyltransferase Inhibitor II
CAS:<p>Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity</p>Fórmula:C20H16Br2O3Pureza:97.13%Cor e Forma:SolidPeso molecular:464.15SYP-5
CAS:<p>SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.</p>Fórmula:C18H16O3SPureza:98.31%Cor e Forma:SolidPeso molecular:312.38MOZ-IN-2
CAS:<p>MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).</p>Fórmula:C17H13FN4O3SPureza:99.17%Cor e Forma:SolidPeso molecular:372.37Amodiaquine dihydrochloride dihydrate
CAS:<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Fórmula:C20H28Cl3N3O3Pureza:99.97%Cor e Forma:SolidPeso molecular:464.82AW68
CAS:<p>AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.</p>Fórmula:C22H21ClN6Pureza:98.52% - 98.52%Cor e Forma:SoildPeso molecular:404.89MS417
CAS:<p>MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak</p>Fórmula:C20H19ClN4O2SPureza:99.87%Cor e Forma:SolidPeso molecular:414.91Golidocitinib
CAS:<p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).</p>Fórmula:C25H31N9O2Pureza:98.87% - 99.88%Cor e Forma:SolidPeso molecular:489.57BRD4 Inhibitor-10
CAS:<p>BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).</p>Fórmula:C25H27N5O2Pureza:99.53%Cor e Forma:SolidPeso molecular:429.51Valemetostat
CAS:<p>Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.</p>Fórmula:C26H34ClN3O4Pureza:98.38% - 99.08%Cor e Forma:SolidPeso molecular:488.02Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.84%Cor e Forma:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecular:323.13Niraparib (R-enantiomer)
CAS:<p>Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).</p>Fórmula:C19H20N4OPureza:99.83%Cor e Forma:SolidPeso molecular:320.39mTOR/HDAC-IN-1 HCl
<p>mTOR/HDAC-IN-1 HCl，a dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagic and apoptosis-inducing effects for cancer</p>Fórmula:C23H24ClN11O3Pureza:99.56%Cor e Forma:SoildPeso molecular:537.96Gusacitinib
CAS:<p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>Fórmula:C24H28N8O2Pureza:98.06% - 99.94%Cor e Forma:SolidPeso molecular:460.53MAK683
CAS:<p>MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).</p>Fórmula:C20H17FN6OPureza:98.25% - 99.92%Cor e Forma:SolidPeso molecular:376.39Nefiracetam
CAS:<p>Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.</p>Fórmula:C14H18N2O2Pureza:97.37%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:246.3Uzansertib phosphate
CAS:<p>Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.</p>Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Cor e Forma:SolidPeso molecular:611.51ZL0580
CAS:<p>ZL0580 suppresses HIV by blocking Tat activation, halting transcription, and promoting repressive chromatin at the HIV promoter.</p>Fórmula:C25H23F3N4O4SPureza:99.70%Cor e Forma:SolidPeso molecular:532.53Amifostine
CAS:<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>Fórmula:C5H15N2O3PSPureza:99.88%Cor e Forma:White SolidPeso molecular:214.22A-485
CAS:<p>A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.</p>Fórmula:C25H24F4N4O5Pureza:98.01% - 99.44%Cor e Forma:SolidPeso molecular:536.48Tranylcypromine (2-PCPA) hydrochloride
CAS:<p>Tranylcypromine (2-PCPA) HCl, a MAO inhibitor, treats major, dysthymic, and atypical depression.</p>Fórmula:C9H11N·HClPureza:99.48% - 99.86%Cor e Forma:SolidPeso molecular:169.66iso-Azalansta
CAS:<p>(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.</p>Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Cor e Forma:SoildPeso molecular:429.96PT2399
CAS:<p>PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.</p>Fórmula:C17H10F5NO4SPureza:98.8% - 99.45%Cor e Forma:SolidPeso molecular:419.32ODM-207
CAS:<p>ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.</p>Fórmula:C22H21N3O3Pureza:99.75%Cor e Forma:SolidPeso molecular:375.42Chitosan oligosaccharide
CAS:<p>Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine.</p>Fórmula:C12H24N2O9Pureza:98%Cor e Forma:SolidPeso molecular:340.327Fenbendazole
CAS:<p>Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.</p>Fórmula:C15H13N3O2SPureza:99.74%Cor e Forma:White To Yellowish PowderPeso molecular:299.35Bufexamac
CAS:<p>Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.</p>Fórmula:C12H17NO3Pureza:99.73%Cor e Forma:Acicular CrystalPeso molecular:223.27SMARCA-BD ligand 1 for Protac
CAS:<p>SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2</p>Fórmula:C14H17N5OPureza:99.93%Cor e Forma:SolidPeso molecular:271.32Miltefosine
CAS:<p>Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.</p>Fórmula:C21H46NO4PPureza:98% - 99.87%Cor e Forma:White To Off-White PowderPeso molecular:407.57L-2-Hydroxyglutaric acid disodium
CAS:<p>L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).</p>Fórmula:C5H6Na2O5Pureza:99.92%Cor e Forma:SolidPeso molecular:192.08ZEN-3694
CAS:<p>ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and can</p>Fórmula:C19H19N5OPureza:98.88% - 99.48%Cor e Forma:SolidPeso molecular:333.39NU6140
CAS:<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Fórmula:C23H30N6O2Pureza:98.33%Cor e Forma:SolidPeso molecular:422.52Brepocitinib P-Tosylate
CAS:<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Fórmula:C25H29F2N7O4SPureza:99.82% - 99.97%Cor e Forma:SolidPeso molecular:561.6Hydralazine hydrochloride
CAS:<p>Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.</p>Fórmula:C8H9ClN4Pureza:99.85% - 99.86%Cor e Forma:Yellow Crystals White Crystalline SolidPeso molecular:196.64Bendazol
CAS:<p>Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.</p>Fórmula:C14H12N2Pureza:98.7% - 99.87%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:208.26N-(3-Aminopropyl)cyclohexylamine
CAS:<p>N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.</p>Fórmula:C9H20N2Pureza:98.05% - 98.82%Cor e Forma:Pale Yellow Clear LiquidPeso molecular:156.2685Ilginatinib maleate
CAS:<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Cor e Forma:SolidPeso molecular:505.5CBP/p300-IN-3
CAS:<p>CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.</p>Fórmula:C24H29N7OPureza:97.38% - 98.08%Cor e Forma:SolidPeso molecular:431.53MS31 trihydrochloride (2366264-12-0 free base)
<p>MS31 trihydrochloride (2366264-12-0 free base) is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor</p>Fórmula:C20H30Cl3N3O2Pureza:99.69%Cor e Forma:SolidPeso molecular:450.83BVT948
CAS:<p>BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.</p>Fórmula:C14H11NO3Pureza:98.87%Cor e Forma:SolidPeso molecular:241.24L002
CAS:<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Fórmula:C15H15NO5SPureza:98.59%Cor e Forma:SolidPeso molecular:321.35Hydroxycitric acid tripotassium hydrate
CAS:<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>Fórmula:C6H7K3O8Pureza:99.85%Cor e Forma:White Solid CrystallinePeso molecular:324.41PBIT
CAS:<p>PBIT is a JARID1 inhibitor with IC50: 3 μM for JARID1B, 6 μM for JARID1A, and 4.9 μM for JARID1C.</p>Fórmula:C14H11NOSPureza:99.61% - 99.83%Cor e Forma:SolidPeso molecular:241.31EBI-2511
CAS:<p>EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).</p>Fórmula:C34H48N4O4Pureza:99.74%Cor e Forma:SolidPeso molecular:576.77M-89
CAS:<p>M-89, a potent menin inhibitor (Kd 1.4 nM), disrupts Menin-MLL interaction, offering possible MLL leukemia treatment.</p>Fórmula:C37H47N5O4SPureza:98.38%Cor e Forma:SolidPeso molecular:657.87Enarodustat
CAS:<p>Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.</p>Fórmula:C17H16N4O4Pureza:99.73% - 99.75%Cor e Forma:SolidPeso molecular:340.33RBN-2397
CAS:<p>RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.</p>Fórmula:C20H23F6N7O3Pureza:98.48% - 99.8%Cor e Forma:SolidPeso molecular:523.43FIDAS-3
CAS:<p>FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities</p>Fórmula:C16H15F2NPureza:97.75%Cor e Forma:SolidPeso molecular:259.29Inobrodib
CAS:<p>Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.</p>Fórmula:C30H32F2N4O3Pureza:98.91% - 99.18%Cor e Forma:SolidPeso molecular:534.6Molidustat
CAS:<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Fórmula:C13H14N8O2Pureza:98.79%Cor e Forma:SolidPeso molecular:314.3N-Desmethyltamoxifen hydrochloride
CAS:<p>N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.</p>Fórmula:C25H28ClNOPureza:99.15%Cor e Forma:SolidPeso molecular:393.95A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Fórmula:C26H35FN4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:486.65Lin28-let-7a antagonist 1
CAS:<p>Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.</p>Fórmula:C31H29N5O7Pureza:99.44%Cor e Forma:SolidPeso molecular:583.59GNE-781
CAS:<p>GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).</p>Fórmula:C27H33F2N7O2Pureza:99.64% - 99.92%Cor e Forma:SolidPeso molecular:525.59Pim-1 kinase inhibitor 8
CAS:<p>Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.</p>Fórmula:C14H17N3O3Pureza:99.81%Cor e Forma:SoildPeso molecular:275.3SNDX-5613
CAS:<p>Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.</p>Fórmula:C32H47FN6O4SPureza:99.12% - 99.74%Cor e Forma:SolidPeso molecular:630.82Ziftomenib
CAS:<p>Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.</p>Fórmula:C33H42F3N9O2S2Pureza:99.65%Cor e Forma:SolidPeso molecular:717.871Glucosamine
CAS:<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>Fórmula:C6H13NO5Pureza:99.8% - 99.8%Cor e Forma:CoaPeso molecular:179.17Tilorone dihydrochloride
CAS:<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>Fórmula:C25H36Cl2N2O3Pureza:98% - 99.86%Cor e Forma:Orange Yellow Crystal PowderPeso molecular:483.47Ilginatinib hydrochloride
CAS:<p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>Fórmula:C21H21ClFN7Pureza:99.55%Cor e Forma:SolidPeso molecular:425.89Citric acid trilithium salt tetrahydrate
CAS:<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>Fórmula:C6H13Li3O11Pureza:99.88%Cor e Forma:White Crystalline PowderPeso molecular:281.98Oltipraz
CAS:<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>Fórmula:C8H6N2S3Pureza:98.79% - 99.77%Cor e Forma:SolidPeso molecular:226.34T-3775440 hydrochloride
CAS:<p>T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).</p>Fórmula:C18H23ClN4OPureza:99.88%Cor e Forma:SolidPeso molecular:346.85BRM/BRG1 ATP Inhibitor-1
CAS:<p>BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member</p>Fórmula:C11H9F3N4O2SPureza:98.17% - 99.84%Cor e Forma:SolidPeso molecular:318.27Delcasertib
CAS:<p>Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).</p>Fórmula:C120H199N45O34S2Pureza:99.96%Cor e Forma:SolidPeso molecular:2880.28Phenelzine sulfate
CAS:<p>Phenelzine sulfate is a non-selective and irreversible inhibitor of monoamine oxidase (MAOI), and with antidepressant and anxiolytic.</p>Fórmula:C8H14N2O4SPureza:98.38% - 99.83%Cor e Forma:SolidPeso molecular:234.27FIDAS-5
CAS:<p>FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.</p>Fórmula:C15H13ClFNPureza:97.66% - 98.3%Cor e Forma:SolidPeso molecular:261.72NI-42
CAS:<p>NI-42, a BRPFs inhibitor: IC50(BRPF1/2/3)=7.9/48/260 nM, Kd(BRPF1/2/3)=40/210/940 nM; selective for class IV BRDs.</p>Fórmula:C18H15N3O3SPureza:99.18%Cor e Forma:SolidPeso molecular:353.39Pulrodemstat benzenesulfonate
CAS:<p>Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally inhibitor of lysine specific demethylase-1 (LSD1) with anticancer effect.</p>Fórmula:C30H29F2N5O5SPureza:97.67%Cor e Forma:SolidPeso molecular:609.64Miglitol
CAS:<p>Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.</p>Fórmula:C8H17NO5Pureza:99.75% - 99.88%Cor e Forma:White To Pale-Yellow Powder SolidPeso molecular:207.22BMS-986158
CAS:<p>BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.</p>Fórmula:C30H33N5O2Pureza:98.78%Cor e Forma:SolidPeso molecular:495.62SJ10542
CAS:<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Fórmula:C41H46N12O5SCor e Forma:SolidPeso molecular:818.95Fluorescein-NAD+
<p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>Cor e Forma:SolidPROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Fórmula:C39H42FN9O7Cor e Forma:SolidPeso molecular:767.81AUR1545
CAS:<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Fórmula:C41H50BrN9O5Pureza:98.84%Cor e Forma:SolidPeso molecular:828.8ZL0590
CAS:<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Fórmula:C23H27F3N4O4SPureza:99.77%Cor e Forma:SoildPeso molecular:512.55PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Cor e Forma:Odour SolidCARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Fórmula:C27H35ClN6O3Cor e Forma:SolidPeso molecular:527.06CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Cor e Forma:SolidKDM1A-IN-29
CAS:<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Fórmula:C16H16ClN3O4SCor e Forma:SoildPeso molecular:381.83UNC10142
<p>UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.</p>Fórmula:C33H52N6O3Cor e Forma:SolidPeso molecular:580.8DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Cor e Forma:Odour SolidSAMS
CAS:<p>SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).</p>Fórmula:C74H131N29O18S2Pureza:98%Cor e Forma:SolidPeso molecular:1779.15NP213
CAS:<p>NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).</p>Fórmula:C42H84N28O7Pureza:98%Cor e Forma:SolidPeso molecular:1093.3Menin-KMT2A-IN-1
<p>Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.</p>Fórmula:C28H35FN6O3Cor e Forma:SolidPeso molecular:522.61TCIP3
CAS:<p>TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.</p>Fórmula:C58H71ClF2N16O7Cor e Forma:SolidPeso molecular:1177.74HSP90/LSD1-IN-1
<p>HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.</p>Cor e Forma:Odour SolidHDAC1-IN-9
<p>HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.</p>Fórmula:C17H17N3O3Cor e Forma:SolidPeso molecular:311.34Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidPROTAC BRD4 Degrader-5
CAS:<p>PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.</p>Fórmula:C50H62ClN9O8S2Cor e Forma:SolidPeso molecular:1016.67Pumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Fórmula:C17H20N8O2SPureza:99.94%Cor e Forma:SoildPeso molecular:400.46Protein Kinase C (19-31)
CAS:<p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>Fórmula:C67H118N26O16Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:1543.82Hyp-dBET1
<p>Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.</p>Cor e Forma:Odour SolidTB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Cor e Forma:Odour SolidHDAC6-IN-53
<p>HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.</p>Cor e Forma:Odour SolidSMD-3236
CAS:<p>SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.</p>Fórmula:C61H75ClN10O5SCor e Forma:SolidPeso molecular:1095.83Uzansertib
CAS:<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Fórmula:C26H26F3N5O3Cor e Forma:SolidPeso molecular:513.51GSK8573
CAS:<p>GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).</p>Fórmula:C20H21NO3Pureza:99.81%Cor e Forma:SolidPeso molecular:323.39PROTAC BRD4 Degrader-19
CAS:<p>PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility</p>Fórmula:C44H38N8O5S2Cor e Forma:SolidPeso molecular:822.95BRD7-IN-1 free base
CAS:<p>BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.</p>Fórmula:C22H26N4O3Pureza:98%Cor e Forma:SolidPeso molecular:394.47GSK040
CAS:<p>GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.</p>Fórmula:C29H34N4O4Cor e Forma:SolidPeso molecular:502.6SMD-3040 TFA
<p>SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.</p>Pureza:98%Cor e Forma:Odour SolidMNK/PIM-IN-1
CAS:<p>MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.</p>Fórmula:C27H27FN6O2Cor e Forma:SolidPeso molecular:486.551Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Cor e Forma:Odour SolidMZP-54
CAS:<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67HIF-1 α (556-574)
CAS:<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Fórmula:C101H150D2N20O34S2Pureza:98%Cor e Forma:SolidPeso molecular:2254.6CDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Fórmula:C32H31ClN6O3Pureza:98.30%Cor e Forma:SoildPeso molecular:583.08MNN-02-155
CAS:<p>MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).</p>Fórmula:C56H68ClF2N15O7Cor e Forma:SolidPeso molecular:1136.69CBP/p300-IN-8
CAS:<p>CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.</p>Fórmula:C27H31N3O4Cor e Forma:SolidPeso molecular:461.562HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Fórmula:C43H63F3N6O6S2Cor e Forma:SolidPeso molecular:881.12Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Fórmula:C14H19ClO8Pureza:98%Cor e Forma:SolidPeso molecular:350.75MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Cor e Forma:Odour SolidSNIPER(BRD)-1
CAS:<p>SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.</p>Fórmula:C53H66ClN9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1056.73PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Pureza:98%Cor e Forma:Odour SolidXF067-68
CAS:<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14KB02-JQ1
CAS:<p>KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.</p>Fórmula:C38H43Cl2N7O6SPureza:98%Cor e Forma:SoildPeso molecular:796.76Namoline
CAS:<p>Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.</p>Fórmula:C10H3ClF3NO4Cor e Forma:SolidPeso molecular:293.58Lyngbyatoxin A
CAS:<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Fórmula:C27H39N3O2Cor e Forma:SolidPeso molecular:437.62PROTAC BET degrader-3
<p>PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.</p>Fórmula:C53H64N12O9SPureza:98%Cor e Forma:SolidPeso molecular:1045.22MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Fórmula:C64H84F3N11O7SCor e Forma:SolidPeso molecular:1208.5Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Fórmula:C15H14O4Cor e Forma:SolidPeso molecular:258.27PROTAC SMARCA2/4-degrader-28
CAS:<p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>Fórmula:C54H68ClN9O11S2Cor e Forma:SolidPeso molecular:1118.75BAY-184
CAS:<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Fórmula:C23H20N2O4SPureza:98.87%Cor e Forma:SolidPeso molecular:420.48Vanicoside A
CAS:<p>Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .</p>Fórmula:C51H50O21Cor e Forma:SolidPeso molecular:998.933β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Fórmula:C30H52O4Cor e Forma:SolidPeso molecular:476.742PROTAC BRD4 Degrader-10
CAS:<p>Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.</p>Fórmula:C59H71F2N9O15S4Cor e Forma:SolidPeso molecular:1312.5R 8605
CAS:<p>R 8605 is a third-generation retinoid.</p>Fórmula:C22H27NO4Cor e Forma:SolidPeso molecular:369.45GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62ZMF-23
<p>ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and</p>Fórmula:C22H23Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:476.36DS-103
<p>DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.</p>Fórmula:C28H33N5O3Cor e Forma:SolidPeso molecular:487.59HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Fórmula:C23H40O5Pureza:98%Cor e Forma:SolidPeso molecular:396.56TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Fórmula:C111H188N42O24S2Pureza:98%Cor e Forma:SolidPeso molecular:2559.1PROTAC BRD4 Degrader-13
CAS:<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Fórmula:C68H85F2N11O17P2S2Cor e Forma:SolidPeso molecular:1492.55Antidiabetic agent 7
<p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>Fórmula:C27H21Cl2N5O3Cor e Forma:SolidPeso molecular:534.39Dihydrochlamydocin
CAS:<p>Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.</p>Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.65UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Fórmula:C74H91ClFN11O17S2Cor e Forma:SolidPeso molecular:1525.16Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidCW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Fórmula:C45H48N6O8Cor e Forma:SolidPeso molecular:800.9SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Fórmula:C44H64N6O9Pureza:98%Cor e Forma:SoildPeso molecular:821.01JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Fórmula:C43H51ClN8O3S2Cor e Forma:SolidPeso molecular:827.5Barasertib
CAS:<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Fórmula:C26H31FN7O6PPureza:99.63% - 99.92%Cor e Forma:SolidPeso molecular:587.54WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576PROTAC BRD4 Degrader-9
CAS:<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Fórmula:C59H71F2N9O15S4Cor e Forma:SolidPeso molecular:1312.5BRD4 degrader-6
CAS:<p>BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.</p>Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28ZXH-3-26
CAS:<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Fórmula:C38H37ClN8O7SPureza:98.90% - 98.90%Cor e Forma:SolidPeso molecular:785.27PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Fórmula:C32H40N4O4Cor e Forma:SolidPeso molecular:544.696PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Fórmula:C27H30F3N7O6S2Pureza:98%Cor e Forma:SolidPeso molecular:669.7Sirtuin modulator 5
CAS:<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Fórmula:C24H23N3O4Cor e Forma:SolidPeso molecular:417.46MAK-683 hydrochloride
CAS:<p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:412.85GSK9311 hydrochloride
CAS:<p>GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).</p>Fórmula:C24H32ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:474Thalidomide-NH-CBP/p300 ligand 2
CAS:<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Fórmula:C48H57F2N11O6Cor e Forma:SolidPeso molecular:922.052SR-0813
CAS:<p>SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.</p>Fórmula:C25H32N6O3SPureza:98.81%Cor e Forma:SolidPeso molecular:496.62KAT6-IN-2
<p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>Cor e Forma:Odour SolidPROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Cor e Forma:Odour SolidAnemonin (6CI)
CAS:<p>Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.</p>Fórmula:C10H8O4Cor e Forma:SolidPeso molecular:192.17GNE-987
CAS:<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Fórmula:C56H67F2N9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1096.31MRS2698
CAS:<p>MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.</p>Fórmula:C9H16N3O13P3SPureza:98%Cor e Forma:SolidPeso molecular:499.22PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06PF-04577806
CAS:<p>PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.</p>Fórmula:C26H37N7O3Cor e Forma:SolidPeso molecular:495.628JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375EXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35
