Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46PNZ5
CAS:<p>PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation</p>Fórmula:C20H18N2O2Pureza:99.51% - 99.61%Cor e Forma:SolidPeso molecular:318.37KBH-A42
CAS:<p>KBH-A42 is an inhibitor of histone deacetylase.</p>Fórmula:C17H22N2O3Pureza:98%Cor e Forma:SolidPeso molecular:302.37JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Fórmula:C25H28N8OPureza:97.89%Cor e Forma:SolidPeso molecular:456.54DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Fórmula:C15H23N7O4SPureza:98%Cor e Forma:SolidPeso molecular:397.45JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Fórmula:C20H18FN5O3SPureza:99.53%Cor e Forma:SolidPeso molecular:427.45(2R/S)-6-PNG
CAS:<p>(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.</p>Fórmula:C20H20O5Pureza:98%Cor e Forma:SolidPeso molecular:340.37SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Cor e Forma:SolidPeso molecular:378.79SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Fórmula:C20H23N7OPureza:99.70%Cor e Forma:SolidPeso molecular:377.44KP-302
CAS:<p>KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.</p>Fórmula:C20H23N5O2Pureza:99.77%Cor e Forma:SolidPeso molecular:365.43JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Fórmula:C20H18ClN7OPureza:98%Cor e Forma:SolidPeso molecular:407.86Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Fórmula:C33H42ClN3O7SPureza:98%Cor e Forma:SolidPeso molecular:660.22BET-IN-7
CAS:<p>BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.</p>Fórmula:C18H12ClN3OSCor e Forma:SolidPeso molecular:353.83Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Fórmula:C18H16N4OPureza:98%Cor e Forma:SolidPeso molecular:304.35GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Cor e Forma:SolidPeso molecular:348.33Ilorasertib hydrochloride
CAS:<p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>Fórmula:C25H22ClFN6O2SPureza:98.45%Cor e Forma:SolidPeso molecular:525JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Fórmula:C19H15FN4OPureza:98.27%Cor e Forma:SolidPeso molecular:334.35Aurora kinase inhibitor-10
CAS:<p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>Fórmula:C21H19F5N6O4SCor e Forma:SolidPeso molecular:546.47MT477
CAS:<p>MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.</p>Fórmula:C31H30N2O12S3Cor e Forma:SolidPeso molecular:718.77Rucaparib camsylate
CAS:<p>Rucaparib camsylate, a PARP-1, -2, -3 inhibitor (Ki=1.4 nM for PARP-1) & H6PD blocker, may treat resistant prostate cancer.</p>Fórmula:C19H18FN3O·xC10H16O4SCor e Forma:SolidHIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Fórmula:C17H15N5O3SCor e Forma:SolidPeso molecular:369.4dWIZ-1
CAS:<p>dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader tha induction of haemoglobin fetalis (HbF) in erythroblasts, sickle cell disease (SCD).</p>Fórmula:C22H29N3O4Pureza:92.87% - 92.87%Cor e Forma:SolidPeso molecular:399.48Y08284
CAS:<p>Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.</p>Fórmula:C26H25FN4O4Cor e Forma:SolidPeso molecular:476.5HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SCor e Forma:SolidPeso molecular:342.35Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23Bizine
CAS:<p>Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.</p>Fórmula:C18H23N3OCor e Forma:SolidPeso molecular:297.39Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07HDAC3-IN-T247
CAS:<p>HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.</p>Fórmula:C21H19N5OSPureza:98.11% - 98.94%Cor e Forma:SolidPeso molecular:389.47SIRT1-IN-2
CAS:<p>SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].</p>Fórmula:C13H15ClN2OCor e Forma:SolidPeso molecular:250.72IDO1 and HDAC1 Inhibitor
CAS:<p>IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).</p>Fórmula:C25H22BrFN8O4Pureza:98%Cor e Forma:SolidPeso molecular:597.4HDAC-IN-49
<p>HDAC-IN-49: potent, broad HDAC inhibitor; IC50s: 10-1880 nM for HDAC1-6; strong anti-leukemic, low toxicity to healthy cells.</p>Fórmula:C26H27FN4O4Cor e Forma:SolidPeso molecular:478.52CYP51/HDAC-IN-1
CAS:<p>Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.</p>Fórmula:C30H40F2N6O4Cor e Forma:SolidPeso molecular:586.67TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Cor e Forma:SolidPeso molecular:288.22Sirt1/2-IN-1
CAS:<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Fórmula:C22H13ClN2OS2Cor e Forma:SolidPeso molecular:420.93HDAC6-IN-15
<p>HDAC6-IN-15: selective HDAC6 inhibitor, IC50 of 38.2 nM, for cancer and neurodegenerative research.</p>Fórmula:C25H28FFeN3O2Cor e Forma:SolidPeso molecular:477.35M133
CAS:<p>M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Fórmula:C23H24N4OS2Cor e Forma:SolidPeso molecular:436.59CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Fórmula:C10H10N2O4Cor e Forma:SolidPeso molecular:222.2Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Fórmula:C18H23BrN4O2Cor e Forma:SolidPeso molecular:407.312PIM-1 Inhibitor 2
CAS:<p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75MI-2-2
CAS:<p>MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.</p>Fórmula:C17H20F3N5S2Pureza:99.65%Cor e Forma:SolidPeso molecular:415.5OUL245
CAS:<p>OUL245: A selective PARP2 inhibitor (IC50=44nM), also inhibits other PARPs/TNKS (IC50=2.9-8.8μM).</p>Fórmula:C8H5N3OSCor e Forma:SolidPeso molecular:191.21YM-53601
CAS:<p>YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.</p>Fórmula:C21H22ClFN2OPureza:99.65%Cor e Forma:SolidPeso molecular:372.86IACS-9571
CAS:<p>IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).</p>Fórmula:C32H42N4O8SPureza:98%Cor e Forma:SolidPeso molecular:642.76Tyk2-IN-5
CAS:<p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>Fórmula:C21H19FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:434.43CPI703
CAS:<p>CPI703 is a novel potent and specific CBP/EP300 bromodomain inhibitor.</p>Fórmula:C17H22N4OPureza:98%Cor e Forma:SolidPeso molecular:298.38JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Cor e Forma:SolidPeso molecular:476.57Bromodomain IN-1
CAS:<p>Bromodomain IN-1 is an inhibitor of Bromodomain.</p>Fórmula:C22H23ClN4O3SPureza:98%Cor e Forma:SolidPeso molecular:458.962′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Fórmula:C9H12N4O6Cor e Forma:SolidPeso molecular:272.216-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Cor e Forma:SolidPeso molecular:258.23SB-284851-BT
CAS:<p>SB-284851-BT: BRD4/p38α/BRDT inhibitor; IC50: BRD4-BD1 1.7µM, BRDT 18µM, BRD4 3.7µM; Kd p38α 0.47nM; reduces IL-8, affects c-Myc/NF-κB.</p>Fórmula:C26H26FN5OCor e Forma:SolidPeso molecular:443.52BET-BAY 002 (S enantiomer)
CAS:<p>The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).</p>Fórmula:C22H18ClN5OPureza:98%Cor e Forma:SolidPeso molecular:403.86PKC-IN-4
CAS:<p>PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM.</p>Fórmula:C21H25N5SCor e Forma:SolidPeso molecular:379.52CD161
CAS:<p>CD161: powerful, selective oral BET inhibitor; IC50: 28.2 nM (BRD4 BD1), 7.2 nM (BRD4 BD2); strong anticancer properties.</p>Fórmula:C26H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:435.48YF479
CAS:<p>YF479 is an inhibitor of histone deacetylase that acts by inhibiting breast tumor growth, metastasis, and recurrence.</p>Fórmula:C22H27BrN2O5Pureza:98%Cor e Forma:SolidPeso molecular:479.36TC-E 5001
CAS:<p>dual tankyrase (TNKS) inhibitor</p>Fórmula:C20H19N5O3SPureza:98%Cor e Forma:SolidPeso molecular:409.46DC-CPin7
CAS:<p>DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].</p>Fórmula:C19H22N2O5Cor e Forma:SolidPeso molecular:358.39OICR-0547
CAS:<p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>Fórmula:C28H29F3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:542.55HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Fórmula:C15H11N3O4Cor e Forma:SolidPeso molecular:297.27Cercosporamide
CAS:<p>Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.</p>Fórmula:C16H13NO7Pureza:98%Cor e Forma:SolidPeso molecular:331.28Bisindolylmaleimide II
CAS:<p>protein kinase C (PKC) inhibitor</p>Fórmula:C27H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:438.52LSD1-IN-12
CAS:<p>LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B</p>Fórmula:C16H16N2OCor e Forma:SolidPeso molecular:252.31OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Fórmula:C13H14N4O3SCor e Forma:SolidPeso molecular:306.34SRTCX1002
CAS:<p>SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.</p>Fórmula:C21H19N5O2SPureza:98%Cor e Forma:SolidPeso molecular:405.47AMPK activator 6
CAS:<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Fórmula:C25H28O5Cor e Forma:SolidPeso molecular:408.49ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Fórmula:C36H48N6O3Pureza:99.5%Cor e Forma:SolidPeso molecular:612.8PU141
CAS:<p>PU141 is a novel inhibitor of histone acetyltransferase (HAT).</p>Fórmula:C14H9F3N2OSPureza:98%Cor e Forma:SolidPeso molecular:310.29CHIC35
CAS:<p>CHIC-35 is a selective deacetylase SIRT1 inhibitor.</p>Fórmula:C14H15ClN2OCor e Forma:SolidPeso molecular:262.73OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H29Cl4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:573.34GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Fórmula:C42H55NO8Pureza:98%Cor e Forma:SolidPeso molecular:701.89ET-JQ1-OH
CAS:<p>ET-JQ1-OH is an allele-specific BET inhibitor.</p>Fórmula:C21H21ClN4O2SCor e Forma:SolidPeso molecular:428.93SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Fórmula:C26H17ClN2O8SPureza:98.56%Cor e Forma:SolidPeso molecular:552.94MicroRNA-21-IN-2
CAS:<p>MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.</p>Fórmula:C17H15N3O3SPureza:99.2%Cor e Forma:SolidPeso molecular:341.38CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Fórmula:C26H24ClN3O3Pureza:97.46%Cor e Forma:SolidPeso molecular:461.94BAY1238097
CAS:<p>BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.</p>Fórmula:C25H33N5O3Pureza:98.1% - 98.79%Cor e Forma:SolidPeso molecular:451.56EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Fórmula:C18H17ClN2OCor e Forma:SolidPeso molecular:312.79SPV106
CAS:<p>SPV106 is a ligand of lysine acetyltransferases (KATs).</p>Fórmula:C22H40O4Pureza:98%Cor e Forma:SolidPeso molecular:368.55BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Fórmula:C32H26F3N3O7Pureza:98%Cor e Forma:SolidPeso molecular:621.56(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Fórmula:C15H19N5OCor e Forma:SolidPeso molecular:285.34PI3K/Akt/CREB activator 1
CAS:<p>PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.</p>Fórmula:C19H15F4NO3Cor e Forma:SolidPeso molecular:381.32Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Fórmula:C23H22F5N7OCor e Forma:SolidPeso molecular:507.469JAK3-IN-1
CAS:<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Fórmula:C26H30ClN7O2Cor e Forma:SolidPeso molecular:508.02SRTCX1003
CAS:<p>SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.</p>Fórmula:C23H23N5O3SCor e Forma:SolidPeso molecular:449.53Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Fórmula:C20H16F3N3O4Cor e Forma:SolidPeso molecular:419.35PBRM1-BD2-IN-6
CAS:<p>PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.</p>Fórmula:C16H15ClN2OCor e Forma:SolidPeso molecular:286.76CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.37HDAC3 Inhibitor
CAS:<p>HDAC3 inhibitor: allosteric, Ki=0.16 nM, favors HDAC3 over HDAC1/2, targets specific leukemia cells, EC50=36.37-151.7 nM.</p>Fórmula:C20H23N3O2Cor e Forma:SolidPeso molecular:337.42AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Fórmula:C25H21ClN2O6Cor e Forma:SolidPeso molecular:480.9RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SCor e Forma:SolidPeso molecular:465.56SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Fórmula:C28H21N5OSCor e Forma:SolidPeso molecular:475.56SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:SolidPeso molecular:369.39KDM5-C49
CAS:<p>KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.</p>Fórmula:C15H24N4O3Pureza:98%Cor e Forma:SolidPeso molecular:308.38Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Fórmula:C27H24N8OPureza:98%Cor e Forma:SolidPeso molecular:476.53CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Fórmula:C21H22ClN3Pureza:98%Cor e Forma:SolidPeso molecular:351.87UMB-136
CAS:<p>UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.</p>Fórmula:C24H27N5O2Pureza:98%Cor e Forma:SolidPeso molecular:417.5BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Fórmula:C26H25N5O2S2Cor e Forma:SolidPeso molecular:503.64OTS186935
CAS:<p>OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H26ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:463.96Dimethyl-bisphenol A
CAS:<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Fórmula:C17H20O2Cor e Forma:SolidPeso molecular:256.34TyK2-IN-2
CAS:<p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>Fórmula:C16H18N6OPureza:98%Cor e Forma:SolidPeso molecular:310.35SRI-42127
CAS:<p>SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR that inhibits tumor growth and reduces neuropathic pain following nerve injury.</p>Fórmula:C19H20N6OPureza:99.66%Cor e Forma:SolidPeso molecular:348.4SIRT5 inhibitor 6
CAS:<p>SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.</p>Fórmula:C21H28N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:460.55CTX-0124143
CAS:<p>CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.</p>Fórmula:C17H13FN2O3SPureza:99.16%Cor e Forma:SolidPeso molecular:344.36NSD3-IN-2
CAS:<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.4NSD3-IN-3
CAS:<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Fórmula:C15H17N5O2SCor e Forma:SolidPeso molecular:331.39PRMT5-IN-C17
CAS:<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Fórmula:C18H17N3O4SCor e Forma:SolidPeso molecular:371.415WKS
CAS:<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Fórmula:C24H36ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:462.03NC-III-49-1
CAS:<p>NC-III-49-1: potent BET inhibitor, binds BRD4/BRDT, inhibits cell growth, reduces c-Myc expression.</p>Fórmula:C44H50N4O11S2Cor e Forma:SoildPeso molecular:875.02CL67
CAS:<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Fórmula:C38H42N10O2Cor e Forma:SolidPeso molecular:670.81HDAC-IN-44
CAS:<p>HDAC-IN-44 is an HDAC inhibitor (IC50: 61.2 nM) with strong anti-cancer effects.</p>Fórmula:C26H27BrN4O4Cor e Forma:SolidPeso molecular:539.42PDAT
CAS:<p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>Fórmula:C15H23N3Pureza:98%Cor e Forma:SolidPeso molecular:245.36TM6008
CAS:<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Fórmula:C21H17N5O3Pureza:98%Cor e Forma:SolidPeso molecular:387.39BET bromodomain inhibitor 2
CAS:<p>BET bromodomain inhibitor 2 is a potent inhibitor of the BET-type bromodomain (IC50: 14.1 μM).</p>Fórmula:C23H30N2O5SCor e Forma:SolidPeso molecular:446.56SKF 91488 dihydrochloride
CAS:<p>histamine N-methyltransferase inhibitor</p>Fórmula:C7H19Cl2N3SPureza:98%Cor e Forma:SolidPeso molecular:248.22GDC-4379
CAS:<p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>Fórmula:C21H18ClF2N7O3Cor e Forma:SolidPeso molecular:489.86Y08175
CAS:<p>Y08175, a CBP Bromodomain inhibitor, IC50: 37 nM (AlphaScreen), 178.15 nM (HTRF). Useful in prostate cancer research.</p>Fórmula:C23H19FN4O5Cor e Forma:SolidPeso molecular:450.42RSC-133
CAS:<p>promotes the reprogramming of human somatic cells to pluripotent stem cells</p>Fórmula:C18H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:305.33HDAC6-IN-10
CAS:<p>HDAC6-IN-10 is a potent HDAC6 inhibitor with 0.73 nM IC50, highly selective, and hinders multiple myeloma cell growth.</p>Fórmula:C21H20N4O4Cor e Forma:SolidPeso molecular:392.41MAT2A inhibitor 3
CAS:<p>MAT2A inhibitor 3 can be used in the cancer research.</p>Fórmula:C16H14ClN3OCor e Forma:SolidPeso molecular:299.75MAT2A-IN-5
CAS:<p>MAT2A-IN-5 inhibits MAT2A in tumors, curbing growth in gastric, colon, liver, and pancreatic cancers.</p>Fórmula:C17H12ClF3N2OCor e Forma:SolidPeso molecular:352.74SIRT6-IN-1
CAS:<p>SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.</p>Fórmula:C19H14N4O5SCor e Forma:SolidPeso molecular:410.4JAK3i
CAS:<p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>Fórmula:C18H15FN4O3Pureza:98.61% - 99.81%Cor e Forma:SolidPeso molecular:354.34ABT-472
CAS:<p>ABT-472 is a novel PARP inhibitor</p>Fórmula:C20H28N4O5Cor e Forma:SolidPeso molecular:404.46INCB054329 Racemate
CAS:<p>INCB054329 Racemate is an inhibitor of BET protein.</p>Fórmula:C19H16N4O3Pureza:98%Cor e Forma:SolidPeso molecular:348.36EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Fórmula:C31H49N5O2Pureza:98%Cor e Forma:SolidPeso molecular:523.75IHCH-3064
CAS:<p>IHCH-3064: dual-action cancer immunotherapy, A2AR affinity (Ki 2.2 nM), selective HDAC1 inhibitor (IC50 80.2 nM).</p>Fórmula:C25H21N9O2Cor e Forma:SolidPeso molecular:479.49HDAC6-IN-6
CAS:<p>HDAC6-IN-6: Potent HDAC6 blocker, BBB-permeable, IC50: 0.025μM; inhibits AChE, Aβ 1-42 aggregation; promotes neurite growth, low neurotoxicity.</p>Fórmula:C20H15N3O2Cor e Forma:SolidPeso molecular:329.35A2AAR/HDAC-IN-2
CAS:<p>A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.</p>Fórmula:C23H26N6O4Cor e Forma:SolidPeso molecular:450.49NSC 698600
CAS:<p>NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].</p>Fórmula:C14H12N2O2SCor e Forma:SolidPeso molecular:272.32SPC-180002
CAS:<p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38JAK-IN-18
CAS:<p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>Fórmula:C27H28F2N6O3Cor e Forma:SolidPeso molecular:522.55Setin-1
CAS:<p>Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.</p>Fórmula:C29H21F3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:486.48GSK 525768A
CAS:<p>GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET.</p>Fórmula:C22H22ClN5O2Cor e Forma:SolidPeso molecular:423.9OXFBD03
CAS:<p>OXFBD03 is the bromodomain and extra terminal domain bromodomain family member BRD4(1) inhibitor.</p>Fórmula:C20H19NO4Pureza:98%Cor e Forma:SolidPeso molecular:337.37LY 170198
CAS:<p>LY 170198 is a protein kinase C inhibitor.</p>Fórmula:C22H25N5O5Pureza:98%Cor e Forma:SolidPeso molecular:439.46HPCG
CAS:<p>HPCG is an inhibitor of HIF-1α prolyl hydroxylase.</p>Fórmula:C8H8N2O4Cor e Forma:SolidPeso molecular:196.16DHPCC-9
CAS:<p>DHPCC-9 is an inhibitor of Pim kinase.</p>Fórmula:C15H10N2OCor e Forma:SolidPeso molecular:234.25DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Fórmula:C25H23Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:452.38Sirtuin modulator 4
CAS:<p>Sirtuin modulator 4 inhibits SIRT1 (EC50: 51-100 μM), may extend cell life and prevent diseases like diabetes and cancer.</p>Fórmula:C18H10N2O2SCor e Forma:SolidPeso molecular:318.35DCE_254
CAS:<p>DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C21H17N9OSPureza:98%Cor e Forma:SolidPeso molecular:443.48Langkamide
CAS:<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Fórmula:C16H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:303.31I-BET151 dihydrochloride
CAS:<p>I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.</p>Fórmula:C23H23Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:488.37Vibsanin A
CAS:<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Fórmula:C25H38O4Cor e Forma:SolidPeso molecular:402.57BF1
CAS:<p>BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.</p>Fórmula:C12H12ClN3SCor e Forma:SolidPeso molecular:265.76Farnesylthiotriazole
CAS:<p>Farnesylthiotriazole is a persistent PKC activator agent.</p>Fórmula:C17H27N3SPureza:98%Cor e Forma:SolidPeso molecular:305.48Tenovin-D3
CAS:<p>Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.</p>Fórmula:C22H27Cl3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:533.9ML399
CAS:<p>ML399 inhibits menin-MLL interaction, targeting MLL leukemia cells with selective, potent action.</p>Fórmula:C27H28FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:445.53iBRD4-BD1
CAS:<p>iBRD4-BD1 inhibits BRD4 bromodomain selectively with 12 nM IC50, useful in inflammation and cancer research.</p>Fórmula:C29H30F3N5OCor e Forma:SolidPeso molecular:521.58HIF-IN-33
CAS:<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Fórmula:C21H17F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:414.38CPI-905
CAS:<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36BET-BAY 002
CAS:<p>BET-BAY 002 is an effective BET bromodomain inhibitor demonstrating efficacy in vivo and in vitro against multiple myeloma and leukaemia models.</p>Fórmula:C22H18ClN5OCor e Forma:SolidPeso molecular:403.86Fagaronine chloride
CAS:<p>Fagaronine chloride is a potent inhibitor of Topoisomerases I.</p>Fórmula:C21H20ClNO4Cor e Forma:SolidPeso molecular:385.84HDAC6-IN-5
CAS:<p>HDAC6-IN-5 (11b), potent HDAC6 blocker, crosses BBB, IC50: 0.025μM, hinders Aβ1-42/AChE aggregation, boosts neurites, low toxicity.</p>Fórmula:C20H14BrN3O2Cor e Forma:SolidPeso molecular:408.25Lobelane Hydrochloride
CAS:<p>Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.</p>Fórmula:C22H30ClNCor e Forma:SolidPeso molecular:343.93TP-238
CAS:<p>"TP-238: Potent CECR2/BPTF dual probe; IC50: 30 nM/350 nM. Inhibits BRD9 (pIC50: 5.9); minimal activity on 338 other kinases."</p>Fórmula:C22H30N6O3SCor e Forma:SolidPeso molecular:458.58CTPB
CAS:<p>CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.</p>Fórmula:C31H43ClF3NO2Pureza:99.77%Cor e Forma:SolidPeso molecular:554.13SirReal-1
CAS:<p>SirReal-1 is an effective and selective inhibitor of Sirt2.</p>Fórmula:C18H18N4OS2Pureza:98%Cor e Forma:SolidPeso molecular:370.49Prospasmine
CAS:<p>Prospasmine is an anticholinergic.</p>Fórmula:C17H28ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:313.87JAK3-IN-12
CAS:<p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>Fórmula:C19H19N5O4SCor e Forma:SolidPeso molecular:413.45Hns 32
CAS:<p>Hns 32 possesses antiarrhythmic properties in dog and guinea pig hearts. It also has vasodilator action.</p>Fórmula:C24H29N3Pureza:98%Cor e Forma:SolidPeso molecular:359.51p32 Inhibitor M36
CAS:<p>p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.</p>Fórmula:C23H28N8O2Pureza:98%Cor e Forma:SolidPeso molecular:448.52AMPK activator 1
CAS:<p>AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).</p>Fórmula:C32H33F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:578.62ST7710AA1
CAS:<p>ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.</p>Fórmula:C20H22N4OCor e Forma:SolidPeso molecular:334.41NCGC00247743
CAS:<p>NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.</p>Fórmula:C24H29N3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.51MI-3
CAS:<p>MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).</p>Fórmula:C18H25N5S2Pureza:98.66% - 99.61%Cor e Forma:SolidPeso molecular:375.55GPI-15427
CAS:<p>GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.</p>Fórmula:C20H20N4O2Cor e Forma:SolidPeso molecular:348.4Binucleine 2
CAS:<p>Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.</p>Fórmula:C13H11ClFN5Cor e Forma:SolidPeso molecular:291.71GSK926
CAS:<p>GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.</p>Fórmula:C29H35N7O2Cor e Forma:SolidPeso molecular:513.63CREBBP-IN-9
CAS:<p>CREBBP-IN-9, a CREBBP inhibitor, acts on the bromodomain of the protein.</p>Fórmula:C16H15N5O2SPureza:98%Cor e Forma:SolidPeso molecular:341.39CPI-1612
CAS:<p>CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.</p>Fórmula:C27H26N6OCor e Forma:SolidPeso molecular:450.53HDAC-IN-28
CAS:<p>HDAC-IN-28 is a novel inhibitor of HDAC that significantly inhibits tumour growth and metastasis.</p>Fórmula:C23H26N4O4SCor e Forma:SolidPeso molecular:454.54SDR-04
CAS:<p>SDR-04 inhibits BRD4-BD1 with high affinity, suppressing MV4;11 cancer cell growth as a BET inhibitor.</p>Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.36H8-A5
CAS:<p>H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.</p>Fórmula:C14H9F3N2O2SPureza:98%Cor e Forma:SolidPeso molecular:326.29ZLD2218
CAS:<p>ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.</p>Fórmula:C22H18N4OCor e Forma:SolidPeso molecular:354.4TK4g
CAS:<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Fórmula:C19H19N3O4SCor e Forma:SolidPeso molecular:385.44BRD4 Inhibitor-19
CAS:<p>BRD4 inhibitors -19 are BET inhibitors that act on BRD4-BD1 (IC50: 55 nM) and can be used to study multiple myeloma.</p>Fórmula:C29H25N5O3Cor e Forma:SolidPeso molecular:491.54Arazine
CAS:<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>Fórmula:C20H33NO3SPureza:90%Cor e Forma:SolidPeso molecular:367.55PARP1-IN-11
CAS:<p>PARP1-IN-11 is a potent PARP1 inhibitor (IC50=0.082 μM), also reducing PARP3, TNKS1, and TNKS2 activity.</p>Fórmula:C16H12N2O4Cor e Forma:SolidPeso molecular:296.28WD2000-012547
CAS:<p>WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).</p>Fórmula:C17H14N2OPureza:98%Cor e Forma:SolidPeso molecular:262.31NV03
CAS:<p>NV03 is a selective antagonist of the UHRF1-H3K9me3 interaction (Kd=2.4 μM) for cancer research. a ligand for E3 ligases in PROTAC synthesis.</p>Fórmula:C19H27N5O2SPureza:99.88%Cor e Forma:SolidPeso molecular:389.52MS453
CAS:<p>MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.</p>Fórmula:C20H27N5O3Cor e Forma:SolidPeso molecular:385.46NR-160
CAS:<p>NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.</p>Fórmula:C25H21F3N6O3Cor e Forma:SolidPeso molecular:510.47M122
CAS:<p>M122 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Fórmula:C24H25N5OS2Cor e Forma:SolidPeso molecular:463.62UMB-32
CAS:<p>UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.</p>Fórmula:C21H23N5OCor e Forma:SolidPeso molecular:361.44CTK7A
CAS:<p>CTK7A is a water-soluble inhibitor of p300. CTK7A inhibits tumor growth in xenografted mice.</p>Fórmula:C28H24N2NaO6Pureza:98%Cor e Forma:SolidPeso molecular:507.498Bromodomain inhibitor-10
CAS:<p>Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.</p>Fórmula:C20H20N4O3Cor e Forma:SolidPeso molecular:364.4MAT2A inhibitor 1
CAS:<p>MAT2A inhibitor 1 is an inhibitor of methionine adenosyltransferase 2A (MATA2) (IC50 < l00 nM).</p>Fórmula:C31H22N6OSCor e Forma:SolidPeso molecular:526.61FNDR-20123 free base
CAS:<p>FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.</p>Fórmula:C21H23N5O2Cor e Forma:SolidPeso molecular:377.44TAK-418
CAS:<p>TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.</p>Fórmula:C17H25ClN2O2SPureza:99.69%Cor e Forma:SolidPeso molecular:356.91SB-429201
CAS:<p>SB-429201 is an effective, selective inhibitor of HDAC1.</p>Fórmula:C28H24N2O3Pureza:98%Cor e Forma:SolidPeso molecular:436.5CAY10669
CAS:<p>CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.</p>Fórmula:C20H22O4Cor e Forma:SolidPeso molecular:326.39JNJ-7925476 free base
CAS:<p>JNJ-7925476 is an TRI antidepressant agent.</p>Fórmula:C20H19NPureza:98%Cor e Forma:SolidPeso molecular:273.37PF-00956980
CAS:<p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>Fórmula:C18H26N6OCor e Forma:SolidPeso molecular:342.44UNC6212 (Kme2)
<p>UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .</p>Fórmula:C39H53N7O11Cor e Forma:SolidPeso molecular:795.88BAY-598 R-isomer
CAS:<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34J1075
CAS:<p>J1075 is an histone deacetylase 8 (HDAC8) inhibitor.</p>Fórmula:C9H6ClNO2SPureza:98%Cor e Forma:SolidPeso molecular:227.67S-Aristeromycinylhomocysteine
CAS:<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Fórmula:C15H22N6O4SCor e Forma:SolidPeso molecular:382.44(R)-OR-S1
CAS:<p>(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.</p>Fórmula:C26H34BrN3O4Pureza:98%Cor e Forma:SolidPeso molecular:532.47
