Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Fórmula:C26H28F3N5O3S2Pureza:98.96%Cor e Forma:SolidPeso molecular:579.66DTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6TPOP146
CAS:<p>TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).</p>Fórmula:C27H35N3O5Pureza:98%Cor e Forma:SolidPeso molecular:481.58PROTAC EZH2 Degrader-1
CAS:<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Fórmula:C54H67N7O8Cor e Forma:SolidPeso molecular:942.15GSK778
CAS:<p>GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.</p>Fórmula:C30H33N5O3Pureza:98.42%Cor e Forma:SolidPeso molecular:511.61KDM4C-IN-1
CAS:<p>KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.</p>Fórmula:C15H14N4O3Pureza:99.33%Cor e Forma:SolidPeso molecular:298.3(2R)-Octyl-α-hydroxyglutarate
CAS:<p>(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.</p>Fórmula:C13H24O5Cor e Forma:SolidPeso molecular:260.33SGC-iMLLT
CAS:<p>SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target</p>Fórmula:C22H24N6OPureza:99.21%Cor e Forma:SolidPeso molecular:388.47Itacitinib adipate
CAS:<p>Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.</p>Fórmula:C32H33F4N9O5Cor e Forma:SolidPeso molecular:699.66TH1834
CAS:<p>TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in MCF.</p>Fórmula:C33H40N6O3Pureza:99.96%Cor e Forma:SolidPeso molecular:568.71GSK2879552
CAS:<p>GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.</p>Fórmula:C23H28N2O2Pureza:99.22%Cor e Forma:SolidPeso molecular:364.48Boc-Lys(Ac)-AMC
CAS:<p>Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).</p>Fórmula:C23H31N3O6Pureza:99.87%Cor e Forma:SolidPeso molecular:445.51AZ505 ditrifluoroacetate
CAS:<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C33H40Cl2F6N4O8Cor e Forma:SolidPeso molecular:805.59EHMT2-IN-1
CAS:<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Fórmula:C18H23N7OCor e Forma:SolidPeso molecular:353.42JET-209
<p>JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) values</p>Fórmula:C46H47N9O6Pureza:98%Cor e Forma:SolidPeso molecular:821.92GSK-J2
CAS:<p>GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.</p>Fórmula:C22H23N5O2Pureza:97.55%Cor e Forma:SolidPeso molecular:389.45Pim-1/2 kinase inhibitor 1
CAS:<p>Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.</p>Fórmula:C11H9NO3SPureza:99.78%Cor e Forma:SolidPeso molecular:235.26GSK9311
CAS:<p>GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).</p>Fórmula:C24H31N5O3Pureza:98%Cor e Forma:SolidPeso molecular:437.53N-Descyclopropanecarbaldehyde Olaparib
CAS:<p>N-Descyclopropanecarbaldehyde Olaparib is a CRBN ligand for dual EGFR/PARP PROTAC, suitable for F-18 radiolabeling and tumor imaging via PET.</p>Fórmula:C20H19FN4O2Cor e Forma:SolidPeso molecular:366.39INO-1001
CAS:<p>INO-1001: potent PARP inhibitor with antitumor properties, enhances radiosensitivity & radiation-induced cell death.</p>Fórmula:C23H25N3O4SCor e Forma:SolidPeso molecular:439.53CHZ868
CAS:<p>CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.</p>Fórmula:C22H19F2N5O2Pureza:99.38%Cor e Forma:SolidPeso molecular:423.42ADTL-SA1215
CAS:<p>ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.</p>Fórmula:C26H29I2NO3Pureza:99.23%Cor e Forma:SolidPeso molecular:657.32(±)-1,2-Diolein
CAS:<p>(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.</p>Fórmula:C39H72O5Cor e Forma:SolidPeso molecular:620.992'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Fórmula:C9H13ClFN3O4Pureza:99.69%Cor e Forma:SolidPeso molecular:281.67MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Cor e Forma:SolidPeso molecular:532.12Fenbendazole-d3
CAS:<p>Fenbendazole-d3 is a deuterated compound of Fenbendazole. Fenbendazole has a CAS number of 43210-67-9. Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.</p>Fórmula:C15H10D3N3O2SCor e Forma:SolidPeso molecular:302.37(R)-GSK-3685032
CAS:<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Fórmula:C22H24N6OSCor e Forma:SolidPeso molecular:420.54Atinvicitinib
CAS:<p>Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.</p>Fórmula:C16H17FN6O3Pureza:99.36%Cor e Forma:SolidPeso molecular:360.35CX-6258 hydrochloride hydrate
CAS:<p>CX-6258 hydrochloride hydrate is a potent and selective inhibitor of pan-Pim kinase that acts on Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM) and Pim-3 (IC50: 16 nM</p>Fórmula:C26H27Cl2N3O4Cor e Forma:SolidPeso molecular:516.42Ilunocitinib
CAS:<p>Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.</p>Fórmula:C17H17N7O2SPureza:99.88%Cor e Forma:SolidPeso molecular:383.43O6BTG-octylglucoside
CAS:<p>O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).</p>Fórmula:C24H34BrN5O7SPureza:98%Cor e Forma:SolidPeso molecular:616.53BAY-850
CAS:<p>BAY-850 is ainhibitor of adenosine triphosphatase family protein 2 that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.</p>Fórmula:C38H44ClN5O3Pureza:98% - 98%Cor e Forma:SolidPeso molecular:654.24DA-3003-1
CAS:<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Cor e Forma:SolidPeso molecular:321.761,4-DPCA ethyl ester
CAS:<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Fórmula:C15H12N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:268.27NSC 694621
CAS:<p>NSC 694621 is a PCAF inhibitor that forms a covalent bond with Cys574, irreversibly inhibiting its acetyltransferase activity, inhibit proliferation,anticancer.</p>Fórmula:C13H10N2O2SPureza:99.7%Cor e Forma:SolidPeso molecular:258.3Anti-PARP1 Antibody (8I163)
<p>Anti-PARP1 Antibody (8I163) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (8I163) can be used in IHC-P.</p>Cor e Forma:Odour LiquidAnti-PARP Antibody (1W26)
<p>Anti-PARP Antibody (1W26) is a Mouse antibody targeting PARP. Anti-PARP Antibody (1W26) can be used in WB,IHC-P,IP.</p>Cor e Forma:Odour LiquidAnti-PARP1 Antibody (6I459)
<p>Anti-PARP1 Antibody (6I459) is an antibody targeting PARP1. Anti-PARP1 Antibody (6I459) can be used in ELISA, IHC.</p>Cor e Forma:Odour LiquidAnti-PARP1 Antibody (7A800)
<p>Anti-PARP1 Antibody (7A800) is an antibody targeting PARP1. Anti-PARP1 Antibody (7A800) can be used in ELISA, WB, IHC.</p>Cor e Forma:Odour LiquidAnti-PARP1 Antibody (9E313)
<p>Anti-PARP1 Antibody (9E313) is a Mouse antibody targeting PARP1. Anti-PARP1 Antibody (9E313) can be used in IHC-P.</p>Cor e Forma:Odour LiquidAnti-PARP1 Antibody (8S756)
<p>Anti-PARP1 Antibody (8S756) is an antibody targeting PARP1. Anti-PARP1 Antibody (8S756) can be used in ELISA, WB, IHC, IF, FCM.</p>Cor e Forma:Odour LiquidGintemetostat
CAS:<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Fórmula:C25H26F4N8O2Cor e Forma:SolidPeso molecular:546.52PR5-LL-CM01
CAS:<p>PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.</p>Fórmula:C23H27N7Cor e Forma:SolidPeso molecular:401.51PROTAC PARP1 degrader
CAS:<p>PROTAC PARP1 degrader suppresses MDA-MB-231 cells at 10 μM, IC50: 6.12 μM in 24h.</p>Fórmula:C58H63Cl2N11O10Pureza:98%Cor e Forma:SolidPeso molecular:1145.1Ifidancitinib
CAS:<p>Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.</p>Fórmula:C20H18FN5O3Pureza:98.05%Cor e Forma:SolidPeso molecular:395.39I-BET567
CAS:<p>I-BET567: potent, oral pan-BET inhibitor; pIC50s: 6.9 (BRD4 BD1), 7.2 (BD2); effective in mouse cancer and inflammation models.</p>Fórmula:C17H18ClN5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:359.817-Chloro-4-(piperazin-1-yl)quinoline
CAS:<p>7-Cl-4-(piperazin-1-yl)quinolone: sirtuin inhibitor, serotonin uptake blocker, antimalarial (D10 IC50 1.18µM, K1 IC50 0.97µM).</p>Fórmula:C13H14ClN3Pureza:99.52%Cor e Forma:Light Yellow SolidPeso molecular:247.72AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Fórmula:C21H16N2O9S2Pureza:97.8%Cor e Forma:SolidPeso molecular:504.49PCAF-IN-1
CAS:<p>PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.</p>Fórmula:C15H11ClN6Cor e Forma:SolidPeso molecular:310.74KDM4-IN-3
CAS:<p>KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations.</p>Fórmula:C17H14N4OCor e Forma:SolidPeso molecular:290.32
