Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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TP-3654
CAS:<p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>Fórmula:C22H25F3N4OPureza:99.8% - 99.95%Cor e Forma:SolidPeso molecular:418.46E7449
CAS:<p>E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.</p>Fórmula:C18H15N5OPureza:97.13%Cor e Forma:SolidPeso molecular:317.34Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Fórmula:C15H12O5Pureza:99.42% - 99.82%Cor e Forma:SolidPeso molecular:272.25Molibresib
CAS:<p>Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).</p>Fórmula:C22H22ClN5O2Pureza:97.70% - 99.08%Cor e Forma:SolidPeso molecular:423.9(+)-JQ1 PA
CAS:<p>(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).</p>Fórmula:C22H20ClN5OSPureza:98.36%Cor e Forma:SolidPeso molecular:437.95WM-1119
CAS:<p>WM-1119 is a highly potent, selective KAT6A/B inhibitor</p>Fórmula:C18H13F2N3O3SPureza:96.59% - 99.58%Cor e Forma:SolidPeso molecular:389.38XD14
CAS:<p>XD14 inhibits BET bromodomains with Kd: BRD4(1) 160nM, BRD2(1) 170nM, BRD3(1) 380nM, BRD3(2) 490nM, BRD2(2) 830nM, BRD4(2) 850nM.</p>Fórmula:C20H27N3O5SPureza:97.46%Cor e Forma:SolidPeso molecular:421.51FL-411
CAS:<p>FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.</p>Fórmula:C18H19N3O2SPureza:98.19%Cor e Forma:SolidPeso molecular:341.43GSK3685032
CAS:<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>Fórmula:C22H24N6OSPureza:98.56% - 99.49%Cor e Forma:SolidPeso molecular:420.53Daminozide
CAS:<p>Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.</p>Fórmula:C6H12N2O3Pureza:99.86%Cor e Forma:White Crystalline Solid Physical Description Odorless White Crystals Or Powder (Ntp 1992)Peso molecular:160.17GSK-5959
CAS:<p>GSK-5959 is a selective BRPF1 inhibitor with IC50 ~80 nM, 100-fold more specific than 35 other bromodomains.</p>Fórmula:C22H26N4O3Pureza:98.35% - 98.65%Cor e Forma:SolidPeso molecular:394.47Deucravacitinib
CAS:<p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C20H19D3N8O3Pureza:98.52% - >99.99%Cor e Forma:SolidPeso molecular:425.46Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Fórmula:C23H22N6O2Pureza:97.47% - 99.56%Cor e Forma:SolidPeso molecular:414.46MS436
CAS:<p>MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.</p>Fórmula:C18H17N5O3SPureza:97.95% - 98.92%Cor e Forma:SolidPeso molecular:383.42SNS-314 Mesylate
CAS:<p>SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.</p>Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Cor e Forma:SolidPeso molecular:527.04BAY-598
CAS:<p>BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.</p>Fórmula:C22H20Cl2F2N6O3Pureza:99.18% - 99.78%Cor e Forma:SolidPeso molecular:525.342',3',5'-triacetyl-5-Azacytidine
CAS:<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Fórmula:C14H18N4O8Pureza:98.34%Cor e Forma:SolidPeso molecular:370.31GSK046
CAS:<p>GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.</p>Fórmula:C23H27FN2O4Pureza:99.97%Cor e Forma:SolidPeso molecular:414.47RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Fórmula:C17H14Cl2N6OPureza:97.94%Cor e Forma:SolidPeso molecular:389.24GSK6853
CAS:<p>GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.</p>Fórmula:C22H27N5O3Pureza:98.71% - 99.21%Cor e Forma:SolidPeso molecular:409.48(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Fórmula:C11H8Br2N2O2Pureza:99.88%Cor e Forma:SolidPeso molecular:360Niraparib
CAS:<p>Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.</p>Fórmula:C19H20N4OPureza:98% - 99.91%Cor e Forma:SolidPeso molecular:320.39AKBA
CAS:<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Fórmula:C32H48O5Pureza:97.85% - 99.77%Cor e Forma:SolidPeso molecular:512.72MN-64
CAS:<p>MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.</p>Fórmula:C18H16O2Pureza:99.5% - 99.93%Cor e Forma:SolidPeso molecular:264.32SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:618.57SMI-16a
CAS:<p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:SolidPeso molecular:263.31OF-1
CAS:<p>OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.</p>Fórmula:C17H18BrN3O4SPureza:98.55% - ≥95%Cor e Forma:SolidPeso molecular:440.31AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43SETDB1-TTD-IN-1
CAS:<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Fórmula:C28H31N5O2Pureza:98.26% - 99.96%Cor e Forma:SolidPeso molecular:469.58JMJD7-IN-1
CAS:<p>JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.</p>Fórmula:C16H8Cl2N2O4Pureza:99.66%Cor e Forma:SolidPeso molecular:363.15PF-9366
CAS:<p>PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).</p>Fórmula:C20H19ClN4Pureza:97.28% - 99.88%Cor e Forma:SolidPeso molecular:350.84AG-270
CAS:<p>AG-270 is an allosteric and orally active inhibitor of MAT2A.</p>Fórmula:C30H27N5O2Pureza:98.28% - 98.87%Cor e Forma:SolidPeso molecular:489.57C-82
CAS:<p>C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.</p>Fórmula:C33H34N6O4Pureza:98.86% - 99.66%Cor e Forma:SolidPeso molecular:578.66Itacitinib
CAS:<p>Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.</p>Fórmula:C26H23F4N9OPureza:96.4% - 99.5%Cor e Forma:SolidPeso molecular:553.51A-966492
CAS:<p>A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.</p>Fórmula:C18H17FN4OPureza:98.53% - 99.27%Cor e Forma:SolidPeso molecular:324.35GSK503
CAS:<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Fórmula:C31H38N6O2Pureza:98% - 99.89%Cor e Forma:SolidPeso molecular:526.67PFI-4
CAS:<p>PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.</p>Fórmula:C21H24N4O3Pureza:99.53% - ≥95%Cor e Forma:SolidPeso molecular:380.44NI-57
CAS:<p>NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).</p>Fórmula:C19H17N3O4SPureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:383.42Menin-MLL inhibitor MI-2
CAS:<p>Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.</p>Fórmula:C18H25N5S2Pureza:97.46%Cor e Forma:SolidPeso molecular:375.55Molibresib besylate
CAS:<p>Molibresib besylate (GSK 525762C) is a BET protein family inhibitor used in the study of refractory hematologic malignant diseases.</p>Fórmula:C28H28ClN5O5SPureza:99.64% - 99.64%Cor e Forma:SolidPeso molecular:582.07Oroxylin A
CAS:<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Fórmula:C16H12O5Pureza:98.72% - 99.55%Cor e Forma:SolidPeso molecular:284.26Tofacitinib
CAS:<p>Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.</p>Fórmula:C16H20N6OPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:312.37GSK126
CAS:<p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>Fórmula:C31H38N6O2Pureza:98% - 99.67%Cor e Forma:SolidPeso molecular:526.67Seclidemstat
CAS:<p>Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.</p>Fórmula:C20H23ClN4O4SPureza:98.28% - 99.76%Cor e Forma:SolidPeso molecular:450.94Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Fórmula:C13H18Cl2N4OPureza:98% - 99.81%Cor e Forma:SolidPeso molecular:317.21Remodelin
CAS:<p>Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.</p>Fórmula:C15H14N4SPureza:99.39% - 99.83%Cor e Forma:SolidPeso molecular:282.363PT-2385
CAS:<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Fórmula:C17H12F3NO4SPureza:98.91% - 99.55%Cor e Forma:SolidPeso molecular:383.34Venadaparib
CAS:<p>Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.</p>Fórmula:C23H23FN4O2Pureza:99.86%Cor e Forma:SolidPeso molecular:406.45RN-1 dihydrochloride
CAS:<p>RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).</p>Fórmula:C23H31Cl2N3O2Pureza:99.64%Cor e Forma:SolidPeso molecular:452.42Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Fórmula:C17H18N6Pureza:99.4% - >99.99%Cor e Forma:SolidPeso molecular:306.36
