Metabolismo

<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>PKR-IN-2 is a activator of pyruvate kinase (PKR).</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>10,12-Tricosadiynoic acid: orally active ACOX1 inhibitor, treats metabolic diseases by enhancing lipid/ROS metabolism in mitochondria.</p>

<p>CRAC intermediate 1 (5-(S)-Fluorowillardiine) is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors.</p>

<p>Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.</p>

<p>Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.</p>

<p>LY 195448 (4-(3-(2-Hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide) shows antitumor activity in a mouse tumor model, blocking cells in the mid-stage.</p>

<p>Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.</p>

<p>Adrenochrome (Adraxone), an epinephrine derivative, is cytotoxic, has cardiotoxic effects, and may aid neuro-disease research.</p>

<p>ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.</p>

<p>Oxolamine citrate (AF-438 citrate) is a cough suppressant that is able to be used as a generic drug in many jurisdictions.</p>

<p>JW 642 inhibits MAGL in mouse, rat, human brains (IC50: 7.6, 14, 3.7 nM).</p>

<p>Sucralose (Trichlorosucrose), an artificial sweetener, is not degraded by the body, so it is noncaloric.</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>BAMB-4 inhibits ITPKA, impeding lung tumor cell metastasis, with an IC50 of 37 μM.</p>

<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>

<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>

<p>FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).</p>

<p>AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes</p>

<p>LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).</p>

<p>MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).</p>

<p>Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.</p>

<p>L-Tyrosine ((S)-Tyrosine) is a naturally occurring tyrosine and is synthesized in vivo from L-phenylalanine, considered a non-essential amino acid.</p>

<p>(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll.</p>

<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>

<p>Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.</p>

<p>Managlinat dialanetil (MB06322) is an orally available fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for type 2 diabetes.</p>

<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>

<p>"SLC26A3-IN-1 inhibits SLC26A3, an anion transporter linked to diarrhea, with 340 nM IC50."</p>

<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>

<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>

<p>Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.</p>

<p>TNO155 inhibits SHP2 enzyme with an IC50 of 0.011 μM, potentially aiding cancer treatment.</p>

<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>

<p>4-(Aminomethyl)benzoic acid (PAMBA), an antifibrinolytic, is an unnatural amino acid derivative.</p>

<p>GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).</p>

<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>

<p>OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)</p>

<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>

<p>Vasopressin acetate: cyclic nonapeptide synthesized in the hypothalamus, functions as a neurotransmitter via G protein-coupled receptors.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Hyaluronic acid sodium (MW 100 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>DATPT is a 12WLVSKF17 peptide mimetic molecule with anti-inflammatory and antimicrobial activities.DATPT inhibits the production of reactive oxygen species.</p>

<p>Naringinase, with α-L-rhamnosidase and β-D-glucosidase activities, transforms steroids, antibiotics, and glycosides.</p>

<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>

<p>Hyaluronic acid sodium (MW 2,000,000 kDa) is a high molecular hyaluronic acid sodium, with moisturizing effect, can form a thin layer on the surface of the skin, can slow down the evaporation of water from the surface of the skin.</p>

<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>

<p>Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.</p>

<p>Tert-Buthyl Pitavastatin is a metabolite of Pitavastatin, a potent HMG-CoA reductase inhibitor.</p>

<p>Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.</p>

<p>TH1760 inhibits NUDT15 (IC50=25nM); boosts 6-thioguanine efficacy in leukemia by raising 6-thio-(d)GTP.</p>

<p>Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues.</p>

<p>Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.</p>

<p>Imidacloprid-urea, a byproduct of imidacloprid, may alter its environmental behavior by competing for soil binding sites.</p>

<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>

<p>Emicizumab (ACE 910), a humanized antibody, mimics factor VIII, treating and preventing hemophilia A.</p>

<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>

<p>Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.</p>

<p>Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.</p>

<p>Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.</p>

<p>Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.</p>

<p>Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.</p>

<p>K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM.</p>

<p>(R)-Apremilast ((R)-CC-10004) is the enantiomer of Apremilast and one of the isoindoline derivatives.</p>

<p>Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant</p>

<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>

<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>

<p>MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd.</p>

<p>Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.</p>

<p>Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.</p>

<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>

<p>1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.</p>

<p>PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.</p>

<p>CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.</p>

<p>Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.</p>

<p>Dafadine-A, a dafadine analog, inhibits DAF-9 P450 in C. elegans and mammalian CYP27A1.</p>

<p>Meclofenoxate HCl (Lucidril) boosts memory and cognition; it's a DIMETHYLAMINOETHANOL and p-chlorophenoxyacetic acid ester.</p>

<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>

<p>Olutasidenib (FT-2102), an IDH1 inhibitor (IC50: 21.2/114 nM), is studied for treating AML/MDS and can cross the blood-brain barrier.</p>

<p>Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.</p>

<p>5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.</p>

<p>Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.</p>

<p>Alconil is a biochemical.</p>

<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>

<p>HIF-PHD-IN-3 is a hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.</p>

<p>Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.</p>

<p>DL-Propargylglycine HCl (DL-Propargylglycine HCl) is a cystathionine gamma catabolism enzyme inhibitor that can be used in heart failure studies.</p>

<p>BCI ((E)-BCI) is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.</p>

<p>D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride), a constituent of striated muscle and liver, is used in the treatment of hyperlipoproteinemias.</p>