Metabolismo

<p>DSPE-PEG2000-pPB is a PEG compound comprised of DSPE and the cyclic oligopeptide (pPB). The pPB component exhibits a high binding affinity for PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG2000-pPB is utilizable for drug delivery applications.</p>

<p>Benzo[b]furan-2-carboxaldehyde is a CYP2A6 inhibitor and can be used in biochemical experiments and drug synthesis.</p>

<p>Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) serves as an inhibitor of xanthine oxidase, exhibiting an inhibitory concentration (IC50) value of 29.71 μM [1</p>

<p>Hydroxy bosentan (Ro 48-5033), a Bosentan metabolite, is liver-processed with 10-20% of its activity.</p>

<p>Cerebroside C, a fungal glycosphingolipid from M. grisea, stimulates phytoalexin in rice and enhances wheat germination and growth at 4°C.</p>

<p>DSPE-PEG1000-CSTSMLKAC is a PEG compound composed of DSPE and CSTSMLKAC. The CSTSMLKAC component facilitates phage-mediated targeting to ischemic cardiac tissue. DSPE-PEG1000-CSTSMLKAC is applicable in drug delivery.</p>

<p>DSPE-PEG2000-ANG is a PEG compound composed of DSPE and the dual-targeting ligand (Angiopep-2, ANG). ANG exhibits high binding efficiency to LRP1 and has been used for targeted delivery to gliomas. DSPE-PEG2000-ANG can be utilized in drug delivery applications.</p>

<p>Alcohol oxidase, a key enzyme in the methanol utilization pathway, is derived from yeast peroxisomes.</p>

<p>Compound PDK0326, with CAS No. 6631-94-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0326 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>DSPE-PEG1000-T7 is a PEG compound composed of DSPE and transferrin receptor peptide (T7). The T7 peptide (HAIYPRH) specifically binds to TfR. DSPE-PEG1000-T7 is applicable in drug delivery.</p>

<p>Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis &amp; NASH research.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>DSPE-PEG5000-TH is a PEG compound formed from DSPE and the pH-responsive cell-penetrating peptide (TH). In acidic environments like the tumor microenvironment, TH is activated, allowing it to selectively deliver small molecules, oligonucleotides, proteins, and similar substances into tumor cells.</p>

<p>DSPE-PEG5000-T7 is a PEG-based compound composed of DSPE and transferrin receptor peptide (T7). T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG5000-T7 is applicable in drug delivery.</p>

<p>4-Hydroxybenzoicacid-d4 is a deuterated form of 4-Hydroxybenzoicacid, which is a phenolic derivative of benzoic acid. It is effective in inhibiting most Gram-positive bacteria and some Gram-negative bacteria with an IC50 of 160 μg/mL.</p>

<p>Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM.</p>

<p>Captopril EP Impurity B, an antihypertensive thiol ACE inhibitor with IC50 of 0.025 μM.</p>

<p>DSPE-PEG2000-ESBP is a PEGylated compound composed of DSPE and E-selectin binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells.</p>

<p>Preterramide C is a fungal metabolite that has been found inA.</p>

<p>9c(i472) blocks 15-LO-1 (IC50=0.19μM), lowers NF-κB in RAW-Blue cells, &amp; cuts Nos2/lipid peroxidation in RAW 264.7 at 0.2-5μM.</p>

<p>Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.</p>

<p>Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary</p>

<p>DSPE-PEG2000-T7 is a PEG compound composed of DSPE and the transferrin receptor peptide (T7). The T7 peptide (HAIYPRH) specifically binds to TfR, making DSPE-PEG2000-T7 useful for drug delivery applications.</p>

<p>Abieslacton possesses anti-tumor promoting activity isolated from several Abies genus.</p>

<p>Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is a precursor for all angiotensin peptides.</p>

<p>DSPE-PEG2000-RVG29 is a PEG compound composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB) and can traverse the BBB.</p>

<p>4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone is a microbial metabolism of yangonin, a major styryl lactone from Piper methysticum.</p>

<p>α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.</p>

<p>Fungal metabolite 19,20-Epoxycytochalasin D from Nemania sp. kills P. falciparum; non-toxic to Vero, toxic to BT-549, LLC-PK11, P388 cells.</p>

<p>Guanosine triphosphate tritris (GTP tritris) serves as a crucial enhancer in myocyte differentiation, playing an essential role in regulating miRNA-muscle regulatory factors. It promotes the release of exosomes rich in guanine and guanine-derived molecules, and is considered an activation precursor for RNA synthesis. In mitochondrial functionality, GTP is involved in the entry of proteins into the matrix, which is vital for various regulatory pathways. It initiates peptide synthesis by facilitating the binding of formylmethionine-tRNA to the ribosome, and aids in polypeptide chain elongation. Additionally, GTP acts as a carrier for phosphates and pyrophosphates, channeling chemical energy into specific biosynthetic pathways. It activates signal transduction G proteins, regulates cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases (including Ras and Rho) is indispensable for both proliferation and apoptosis. Furthermore, the small GTPase Rab assists in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is also an energy-rich precursor in the biosynthesis of DNA and RNA enzymes.</p>

<p>AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.</p>

<p>LysoFos Glycerol 16 is a useful organic compound for research related to life sciences. The catalog number is TF0118 and the CAS number is 326495-22-1.</p>

<p>BuChE-IN-15, a chemical compound, exhibits potent inhibitory activity with IC50 values of 81 nM and 400 nM, respectively. It also demonstrates good blood-brain barrier permeability and neuroprotective properties, making it suitable for research in Alzheimer's disease.</p>

<p>N-Lactylvaline is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.</p>

<p>DSPE-PEG5000-PP1 is a PEG compound composed of DSPE and the PP1 peptide, which targets inflammatory atherosclerotic plaques. It can be used for drug delivery.</p>

<p>DSPE-PEG2000-YIGSR is a PEG compound composed of DSPE and the biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin-binding protein (LBP), enhancing the adhesion and proliferation of various cell types, including endothelial cells, fibroblasts, and smooth muscle cells. DSPE-PEG2000-YIGSR is applicable in drug delivery.</p>

<p>D-Sedoheptulose 7-phosphate, a precursor to group III heptaic acid and group IV hygromycin B, converts to NDP-heptose via similar pathways.</p>

<p>1'-Hydroxy bufuralol is a metabolite of bufuralol, an orally active β-adrenoceptor blocker used in the study of hypertension and cardiac arrhythmias.</p>

<p>Berninamycin D, a cyclic peptide derived from Streptomyces bernensis through fermentation, is recognized as a fungal metabolite [1].</p>

<p>18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.</p>

<p>Ninopterin is an experimental antineoplastic and folic acid analog.</p>

<p>Seco Rapamycin, a ring-opened Rapamycin derivative, does not affect mTOR function.</p>

<p>DSPE-PEG1000-VIP is a PEG compound composed of DSPE and the vasoactive intestinal peptide (VIP). It can be utilized for drug delivery.</p>

<p>A4GALT (LgtC) adds galactose to lactosylceramide, forming globotriaosylceramide; used in P1 antigen synthesis.</p>

<p>Senecionine acetate, a pyrrolizidine alkaloid, blocks Ca2+ storage in cells by inactivating sulfhydryl groups.</p>

<p>DSPE-PEG2000-M2pep is a PEG compound formed from DSPE and the M2-polarized macrophage-targeting peptide (M2pep). M2pep acts as a monovalent or multivalent ligand conjugated with pro-apoptotic peptides to specifically target M2 macrophages with toxic effects. DSPE-PEG2000-M2pep is applicable for drug delivery.</p>

<p>MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.</p>

<p>BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.</p>

<p>MC 1046 is an impurity of Calcipotriol. Calcipotriol is a ligand of VDR-like receptors.</p>

<p>Arachidonoyl-L-carnitine chloride is an endogenous metabolite and acylcarnitine widely used in biochemical experiments and studies of metabolic disorders.</p>