Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 67 produtos de "Aminopeptidase"
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RB 101
CAS:<p>RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.</p>Fórmula:C31H38N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:582.84MetAP2-IN-1
CAS:<p>MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].</p>Fórmula:C8H6BrN3Pureza:98%Cor e Forma:SolidPeso molecular:224.06Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Fórmula:C16H24N4O3Cor e Forma:SolidPeso molecular:320.387A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Fórmula:C24H30N2O4SCor e Forma:SolidPeso molecular:442.571EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Fórmula:C4H11NO3S2Cor e Forma:SolidPeso molecular:185.27LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78LTA4H-IN-2
CAS:<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Fórmula:C20H19FN6O2Cor e Forma:SolidPeso molecular:394.4Bestatin methyl ester
CAS:<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Fórmula:C17H26N2O4Cor e Forma:SolidPeso molecular:322.4Ketomethylenebestatin
CAS:<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Fórmula:C17H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:307.38SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Fórmula:C23H38N2O5Peso molecular:422.56PPI-2458
CAS:<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Fórmula:C22H36N2O6Cor e Forma:SolidPeso molecular:424.53QGC583
CAS:<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Fórmula:C13H20NO5PCor e Forma:SolidPeso molecular:301.284-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OCor e Forma:SolidPeso molecular:198.26ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.505Beloranib
CAS:<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Fórmula:C29H41NO6Pureza:98%Cor e Forma:SolidPeso molecular:499.64TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Fórmula:C19H28ClNO6Pureza:98%Cor e Forma:SolidPeso molecular:401.88Actinonin
CAS:<p>Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].</p>Fórmula:C19H35N3O5Cor e Forma:SolidPeso molecular:385.5
