Microbiologia/Virologia
Os inibidores de microbiologia e virologia são compostos que têm como alvo microrganismos, incluindo bactérias, vírus e fungos, interrompendo seu crescimento, replicação ou sobrevivência. Esses inibidores são essenciais para estudar a patogênese microbiana, entender os mecanismos de resistência e desenvolver novas terapias antimicrobianas e antivirais. Os inibidores nessa categoria são usados para combater doenças infecciosas, explorar a ecologia microbiana e investigar as interações hospedeiro-patógeno. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para microbiologia e virologia para apoiar sua pesquisa em doenças infecciosas, microbiologia e virologia.
Subcategorias de "Microbiologia/Virologia"
- Antibacteriano(2.949 produtos)
- Antibiótico(918 produtos)
- Antifecção(23 produtos)
- DHFR(32 produtos)
- Síntese de DNA/RNA(706 produtos)
- HBV(176 produtos)
- HIV Protease(447 produtos)
- HSV(91 produtos)
- Integrase(2 produtos)
- Ribossomo(13 produtos)
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Foram encontrados 5832 produtos de "Microbiologia/Virologia"
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HIV-1 inhibitor-52
CAS:<p>HIV-1 inhibitor-52: potent, broad-spectrum with EC50s 1.6-6.4 nM against various HIV-1 strains.</p>Fórmula:C46H72FNO5SCor e Forma:SolidPeso molecular:770.13DNA ligase-IN-2
CAS:<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Fórmula:C13H8FN3O3Cor e Forma:SolidPeso molecular:273.219NDM-1 inhibitor-3
<p>NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.</p>Fórmula:C16H12O4Pureza:98.66%Cor e Forma:SolidPeso molecular:268.26UMPK ligand 1
CAS:<p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>Fórmula:C15H22N4O5SCor e Forma:SolidPeso molecular:370.424SARS-CoV-2 Mpro-IN-44
CAS:<p>SARS-CoV-2 Mpro-IN-44 (Compound 25) is a broad-spectrum inhibitor of the main protease (Mpro) for coronaviruses. It exhibits inhibitory activity against several high-risk coronaviruses, including SARS-CoV-2 and PEDV, with an IC50 of less than 0.6 μM. The broad inhibition of coronaviruses by SARS-CoV-2 Mpro-IN-44 is achieved through enhanced interaction with conserved sites of Mpro. This compound is a potential candidate for the development of antiviral drugs against coronaviruses.</p>Fórmula:C29H19Cl2FN8O4SCor e Forma:SolidPeso molecular:665.48Colistin adjuvant-2
<p>Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].</p>Fórmula:C14H7Cl2F3N2OCor e Forma:SolidPeso molecular:347.12Omaciclovir
CAS:<p>Omaciclovir (ABT-091) is a herpesvirus herpesvirus replication inhibitor with antiviral activity that is used in the study of herpesvirus infections.</p>Fórmula:C10H15N5O3Pureza:99.46% - 99.46%Cor e Forma:SolidPeso molecular:253.26Cephalosporin C
CAS:<p>Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.</p>Fórmula:C16H21N3O8SCor e Forma:SolidPeso molecular:415.418BRD-K98645985
CAS:<p>BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.</p>Fórmula:C33H43N5O4Pureza:98%Cor e Forma:SolidPeso molecular:573.73Ganaplacide hydrochloride
CAS:<p>Ganaplacide hydrochloride (KAF156 HCl) is an orally administered imidazopyrimidine antimalarial agent that inhibits Plasmodium PI4K activity.</p>Fórmula:C22H24ClF2N5OPureza:93.97%Cor e Forma:SoildPeso molecular:447.91Squalamine lactate
CAS:<p>Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.</p>Fórmula:C37H71N3O8SPureza:98%Cor e Forma:SolidPeso molecular:718.04Saroaspidin B
CAS:<p>Saroaspidin B is a dimeric form of a biphenyl triphenol, characterized as an antibiotic compound.</p>Fórmula:C25H32O8Cor e Forma:SolidPeso molecular:460.52APE1-IN-3
CAS:<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Fórmula:C17H16O4Cor e Forma:SolidPeso molecular:284.31ZINC000104379474
<p>ZINC000104379474 is a compound that targets SARS-CoV-2 endoribonuclease.</p>Fórmula:C27H33N3O10Cor e Forma:SolidPeso molecular:559.57SARS-CoV-2 PLpro-IN-1
CAS:<p>SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent competitive inhibitor of SARS-CoV-2 PLpro with an IC50 value of 15.06 μM and a Ki value of 22.93 μM. It inhibits the proliferation of Vero cells, exhibiting an IC50 of 7.47 μM.</p>Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.376Valopicitabine dihydrochloride
CAS:<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C15H25ClN4O6Cor e Forma:SolidPeso molecular:392.84Antibacterial agent 90
<p>Antibacterial agent 90 (6n), a pleuromutilin derivative, targets Gram-positive pathogens and Mycoplasma pneumoniae.</p>Fórmula:C30H42N2O6Cor e Forma:SolidPeso molecular:526.668-Hydroxyerythromycin A
CAS:<p>8-Hydroxyerythromycin A is a semi-synthetic antibiotic with antibacterial activity.</p>Fórmula:C37H67NO14Cor e Forma:SolidPeso molecular:749.926Anti-Influenza agent 3
<p>Compound 11h: Potent, low-toxicity anti-influenza, inhibits M2 ion channels. EC50: 3.29μM (H3N2), 2.45μM (H1N1).</p>Fórmula:C16H22ClNOSCor e Forma:SolidPeso molecular:311.87Anti-MRSA agent 6
<p>Anti-MRSA agent 6 (compound 3q6) is a potent anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) agent with low cytoxicity for MCF-7, A549 cells [1].</p>Fórmula:C16H11F2N3Cor e Forma:SolidPeso molecular:283.28WM382
CAS:<p>WM382, a potent dual PMIX/X inhibitor, has IC50s of 1.4 nM/0.03 nM and effective against various malaria stages.</p>Fórmula:C29H36N4O4Cor e Forma:SolidPeso molecular:504.62NFC nitro probe 1
CAS:<p>NFC nitro probe 1 (compound 18) is a chemical probe designed for the detection of Mtb, exhibiting high potency against both R-Mtb and NR-Mtb.</p>Fórmula:C19H19NO6Cor e Forma:SolidPeso molecular:357.357(R)-CSN5i-3
CAS:<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Fórmula:C28H29F2N5O2Pureza:99.76% - 99.97%Cor e Forma:SolidPeso molecular:505.56NBD-14189
CAS:<p>NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 <200 nM).</p>Fórmula:C18H16F4N4O2SCor e Forma:SolidPeso molecular:428.40trans-Clopenthixol
CAS:<p>Trans-Clopenthixol ((E)-Clopenthixol) is an antibiotic without any sedative properties. It can be used in vitro to inhibit Pseudomonas aeruginosa and Plasmodium falciparum.</p>Fórmula:C22H25ClN2OSCor e Forma:SolidPeso molecular:400.9652-Acetyl-2-decarboxamidotetracycline
CAS:<p>2-Acetyl-2-decarboxamidotetracycline is a tetracycline-class antibiotic. It exhibits a UV absorption spectrum similar to that of tetracycline or 5-oxytetracycline at concentrations above 300 mμ, characteristic of the BCD ring system.</p>Fórmula:C23H25NO8Cor e Forma:SolidPeso molecular:443.45Fabimycin
CAS:<p>Fabimycin, a FabI inhibitor, combats drug-resistant gram-negative bacterial infections effectively.</p>Fórmula:C23H25ClN4O3Cor e Forma:SolidPeso molecular:440.92Dioxidine
CAS:<p>Dioxidine is an antimicrobial agent that can inhibit bacterial growth. It is utilized in research on pyogenic infections.</p>Fórmula:C10H10N2O4Cor e Forma:SolidPeso molecular:222.197Etofamide
CAS:<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Fórmula:C19H20Cl2N2O5Cor e Forma:SolidPeso molecular:427.28Plm IV inhibitor-2
CAS:<p>"Plm IV inhibitor-2: Potent for Plm IV (IC50=24nM), affects Plm II/Plm I; malaria research compound."</p>Fórmula:C39H54N4O4Cor e Forma:SolidPeso molecular:642.87Saphenamycin
CAS:<p>Saphenamycin is an antibiotic from a strain of Streptomyces.</p>Fórmula:C23H18N2O5Pureza:98%Cor e Forma:SolidPeso molecular:402.40Chitin synthase inhibitor 11
<p>Potent CHS inhibitor with an IC50 of 0.10 mM; exhibits broad-spectrum antifungal properties.</p>Fórmula:C24H24N4O8Cor e Forma:SolidPeso molecular:496.47PLP_Snyder530
<p>PLP_Snyder530, a potent PL pro inhibitor, halts SARS-CoV-2 by triggering protease conformation changes.</p>Fórmula:C24H24N2O2Cor e Forma:SolidPeso molecular:372.46RSV-IN-5
CAS:<p>RSV-IN-5: Dual inhibitor for RSV fusion proteins, effective on wild-type A2 and D486N mutant with EC50s of 2.0 nM & 8.1 nM. Potent anti-RSV.</p>Fórmula:C28H37N7O2Cor e Forma:SolidPeso molecular:503.64Antileishmanial agent-6
<p>Antileishmanial agent-6: potent against Leishmania donovani, IC50 0.54μM; cytotoxic IC50 10.2μM.</p>Fórmula:C24H26O8Cor e Forma:SolidPeso molecular:442.46BAY-364
CAS:<p>BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+</p>Fórmula:C23H19N3O4Cor e Forma:SolidPeso molecular:401.41Saptomycin E
CAS:<p>Saptomycin E is an antitumor antibiotic.</p>Fórmula:C33H35NO9Cor e Forma:SolidPeso molecular:589.63LolCDE-IN-2
CAS:<p>LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1].</p>Fórmula:C22H17N5OPureza:98%Cor e Forma:SolidPeso molecular:367.40Kikumycin A
CAS:<p>Kikumycin A, an antibiotic produced by Streptomyces, exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria. Additionally, it demonstrates antitrichomonal activity with a minimum inhibitory concentration (MIC) of 25 μg/mL against Trichomonas foetus.</p>Fórmula:C13H17N7O2Cor e Forma:SolidPeso molecular:303.32ddCTP trisodium
<p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>Fórmula:C9H13N3Na3O12P3Cor e Forma:SolidPeso molecular:517.1HCV-IN-40
CAS:<p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>Fórmula:C21H26BrFN3O9PCor e Forma:SolidPeso molecular:594.32Chitin synthase inhibitor 1
<p>Potent, selective CHS inhibitor with 0.12 mM IC50; effective against drug-resistant fungi.</p>Fórmula:C22H20ClN3O3Cor e Forma:SolidPeso molecular:409.87Chitin synthase inhibitor 8
<p>Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal effects that can be used in studies related to fungal infections</p>Fórmula:C23H23N3O5Cor e Forma:SolidPeso molecular:421.45GTSE1-IN-1
CAS:<p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>Fórmula:C21H24FN7Cor e Forma:SolidPeso molecular:393.46YKL-04-085
CAS:<p>YKL-04-085 inhibits viral translation effectively, with strong antiviral action at much lower doses than those affecting host-cell growth.</p>Fórmula:C30H29N5O2Cor e Forma:SolidPeso molecular:491.6Ibafloxacine
CAS:<p>Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect against</p>Fórmula:C15H14FNO3Pureza:97.67%Cor e Forma:SolidPeso molecular:275.27Anti-MRSA agent 27
CAS:<p>Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.</p>Fórmula:C15H10F3N3OSCor e Forma:SolidPeso molecular:337.32A25822B
CAS:<p>A25822B is an antifungal agent.</p>Fórmula:C28H45NOPureza:98%Cor e Forma:SolidPeso molecular:411.66β-Glucuronidase-IN-2
<p>β-Glucuronidase-IN-2 is a potent inhibitor of E.</p>Fórmula:C21H17Cl3O7Cor e Forma:SolidPeso molecular:487.71Anti-infective agent 10
CAS:<p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>Fórmula:C26H25N3O7SCor e Forma:SolidPeso molecular:523.56GSK-3036656 free base
CAS:<p>GSK656 (GSK3036656) inhibits Mtb LeuRS with IC50 of 0.20 μM, promising for tuberculosis treatment.</p>Fórmula:C10H13BClNO4Cor e Forma:SolidPeso molecular:257.48Antibacterial agent 77
<p>Antibacterial agent 77 (compound 12) is an antibacterial agent [1].</p>Fórmula:C22H27N3OSCor e Forma:SolidPeso molecular:381.53FG-2101
CAS:<p>FG-2101 is a selective, orally active non-hydroxamate LpxC inhibitor with an IC50 of approximately 1 nM. It demonstrates exceptional selectivity over other bacterial and human metalloproteases. FG-2101 is useful for studying infections caused by Gram-negative bacteria, including resistant strains.</p>Fórmula:C30H32N5O6PCor e Forma:SolidPeso molecular:589.57917,17-Ethylendioxyandrost-5-en-3β-ol
CAS:<p>17,17-Ethylendioxyandrost-5-en-3β-ol, with an EC 50 of 629 μM, acts as an inhibitor of HSV-1. This compound is applicable in research studies focusing on viral infections.</p>Fórmula:C21H32O3Cor e Forma:SolidPeso molecular:332.48Antibacterial agent 261
CAS:<p>Antibacterialagent 261 (compound 43) is a potent inhibitor of the peptide deformylase (PDF) enzyme, demonstrating IC50 values of 2.5 nM against Staphylococcus aureus (S. aureus) and 10.6 nM against Escherichia coli (E. coli).</p>Fórmula:C18H24N4O3S2Cor e Forma:SolidPeso molecular:408.538NBTIs-IN-4
<p>NBTIs-IN-4, a broad-spectrum Gram-positive antibacterial, inhibits DNA rotamases/topoisomerase IV, with low resistance.</p>Fórmula:C22H24FN5O5SCor e Forma:SolidPeso molecular:489.52HT1171
CAS:<p>HT1171 is a potent and selective inhibitor of the Mycobacterium tuberculosis proteasome. It exhibits strong antitubercular activity against Mycobacterium tuberculosis H37Rv, with a MIC90 of 2 μg/mL and MIC of 4 μg/mL. At a concentration of 100 μM, HT1171 shows an inhibition rate of 53.8% against normal human liver cells (L02). HT1171 is applicable in antituberculosis drug research.</p>Fórmula:C7H4N2O4S2Cor e Forma:SolidPeso molecular:244.248HIV-1 inhibitor-17
<p>HIV-1 inhibitor-18 blocks HIV-1 capsid, acts on NL4-3 strain (EC50: 2.57 μM), has low cytotoxicity (MT-4 CC50: >8.55).</p>Fórmula:C32H32N4O5SCor e Forma:SolidPeso molecular:584.69HBV-IN-48
CAS:<p>HBV-IN-48, an HBV inhibitor, exhibits potent antiviral activity against HBV in HepDE19 cells, demonstrated by its EC 50 value of 0.005 μM. Additionally, it effectively reduces serum HBV DNA levels in mouse models of HBV infection.</p>Fórmula:C22H15F4N3O3Cor e Forma:SolidPeso molecular:445.37Antibacterial agent 66
<p>Compound 6q, a trifluoromethylpyridine oxadiazole, targets Xanthomonas oryzae with EC50 of 7.2 μg/mL.</p>Fórmula:C17H10ClF6N3O2SCor e Forma:SolidPeso molecular:469.79RCB18350
CAS:<p>RCB18350 is an antituberculosis agent and an isoxazole derivative. It demonstrates bacteriostatic properties by inhibiting the growth of Mycobacterium tuberculosis, with a minimum inhibitory concentration (MIC) of 1.25 μg/mL. RCB18350 is effective against multi-drug resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, Mycobacterium bovis BCG, and Mycobacterium avium, all of which are slow-growing mycobacteria.</p>Fórmula:C19H18F3N3O4SCor e Forma:SolidPeso molecular:441.424D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Fórmula:C19H22N4O3Cor e Forma:SolidPeso molecular:354.403(Rac)-Plevitrexed
CAS:<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Fórmula:C26H25FN8O4Pureza:98%Cor e Forma:SolidPeso molecular:532.53PRRSV-IN-1
CAS:<p>PRRSV-IN-1 (Compound 4s) acts as an inhibitor of the nsp4 protease of PRRSV. It has an EC50 value of 0.45 μM against PRRSV, binds to the nsp4 protease with a Kd of 29.24 pM, and exhibits an IC50 value of 80.36 pM for nsp4 protease inhibition. PRRSV-IN-1 is applicable in antiviral infection research.</p>Fórmula:C19H18BrNO3Cor e Forma:SolidPeso molecular:388.255Ciluprevir
CAS:<p>Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.</p>Fórmula:C40H50N6O8SPureza:98%Cor e Forma:SolidPeso molecular:774.93PLpro-IN-6
CAS:<p>PLpro-IN-6 (compound 6) serves as an inhibitor for the papain-like protease (PLpro), demonstrating potent activity with an IC 50 of 0.019 μM against the SARS-CoV-2 PLpro enzyme.</p>Fórmula:C29H30N6OCor e Forma:SolidPeso molecular:478.59GC373
CAS:<p>GC373, an effective inhibitor of the SARS-CoV-2 M pro, impedes virus replication, exhibiting an inhibition concentration (IC 50) of 0.4 μM. This compound is valuable for use in anti-COVID-19 research.</p>Fórmula:C21H29N3O5Cor e Forma:SolidPeso molecular:403.47Alpibectir
CAS:<p>Alpibectir has antibacterial activity [1].</p>Fórmula:C12H14F6N2O2Cor e Forma:SolidPeso molecular:332.24TLR8 agonist 4
<p>TLR8 agonist 4 inhibits wild-type and lamivudine/entecavir-resistant HBV; IC50: 0.15 μM and 0.10 μM.</p>Fórmula:C28H27N5O5SCor e Forma:SolidPeso molecular:545.61Imidocarb dihydrochloride monohydrate
<p>Imidocarb dihydrochloride monohydrate is an effective antiprotozoal agent against the parasite B. bovis (IC50: 87 μg/ml).</p>Fórmula:C19H24Cl2N6O2Cor e Forma:SolidPeso molecular:439.34LN002
CAS:<p>LN002 is an orally active inhibitor of Cryptosporidium oxidase, utilized for research in cryptosporidiosis.</p>Fórmula:C22H15N7Cor e Forma:SolidPeso molecular:377.40PFK-IN-1
CAS:<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Fórmula:C18H15Cl2N3O4SCor e Forma:SolidPeso molecular:440.3Anti-Trypanosoma cruzi agent-1
<p>Anti-Trypanosoma cruzi agent-1 (Compd E5) has a potent anti-Toxoplasma effect.</p>Fórmula:C23H29N3O5Cor e Forma:SolidPeso molecular:427.49Ep vinyl quinidine
CAS:<p>3-Epiquinine is a Quinidine stereoisomer, used in malaria, antiarrhythmic, inhibits P450db, and blocks K+ channels, IC50: 19.9 μM.</p>Fórmula:C20H24N2O2Cor e Forma:SolidPeso molecular:324.42Chitin synthase inhibitor 6
<p>Compound 9b inhibits CHS with an IC50 of 0.21 mM; it's a broad-spectrum antifungal, effective against resistant strains.</p>Fórmula:C24H25N3O6Cor e Forma:SolidPeso molecular:451.47SPR7
<p>SPR7 is a potent and selective rhodesain inhibitor (Ki: 0.51 nM). SPR7 exhibited antiparasitic effects against T. b. brucei (EC50: 1.65 μM).</p>Fórmula:C30H32ClN3O3Cor e Forma:SolidPeso molecular:518.05Saussureamine C
CAS:<p>Saussureamine C is an inhibitor of H274Y and N294S mutants.</p>Fórmula:C19H26N2O5Cor e Forma:SolidPeso molecular:362.42HIV-1 inhibitor-13
<p>HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).</p>Fórmula:C30H32N6O3Cor e Forma:SolidPeso molecular:524.61Trypanothione synthetase-IN-4
<p>Trypanothione synthetase-IN-4, an L. infantum inhibitor, has potent anti-leishmanicidal properties (EC50: 0.6 μM).</p>Fórmula:C29H52INO2Cor e Forma:SolidPeso molecular:573.63BRL-42715
CAS:<p>BRL-42715 is an effective inhibitor of bacterial beta-lactamases.</p>Fórmula:C10H7N4NaO3SPureza:98%Cor e Forma:SolidPeso molecular:286.24Cyclophilin inhibitor 1
CAS:<p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>Fórmula:C31H39N5O7Pureza:98%Cor e Forma:SolidPeso molecular:593.67ZIKV-IN-4
<p>ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.</p>Fórmula:C33H37NO4Cor e Forma:SolidPeso molecular:511.65DNDI-8219
CAS:<p>DNDI-8219 is an antitubercular agent. It has potent antileishmanial effects.</p>Fórmula:C13H10F3N3O5Cor e Forma:SolidPeso molecular:345.23UNI418
CAS:<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Fórmula:C22H16N6Cor e Forma:SolidPeso molecular:364.40Diploicin
CAS:<p>Diploicin is a dibenzofuran lactone compound with activity against Gram-positive bacteria, found in lichens (lichens).</p>Fórmula:C16H10Cl4O5Cor e Forma:SolidPeso molecular:424.06DHX9-IN-19
CAS:<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Fórmula:C20H21ClN4O4S2Cor e Forma:SolidPeso molecular:480.988NS2B/NS3-IN-4
CAS:<p>Compound 34e inhibits DENV2/ZIKV proteases; IC50: 0.69 µM (DENV2), 1.04 µM (ZIKV).</p>Fórmula:C15H11NO4Cor e Forma:SolidPeso molecular:269.25HIV-IN-3
<p>HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.</p>Fórmula:C21H32ClN7O3Cor e Forma:SolidPeso molecular:465.98Anticancer agent 36
<p>Compound 11: Sulfonylurea derivative, antimicrobial, anticancer; MIC 0.039-0.156 mg/mL; A549 IC50: 19.7 μg/mL, PC3 IC50: 11.9 μg/mL.</p>Fórmula:C21H17N3O3S2Cor e Forma:SolidPeso molecular:423.51Cap-dependent endonuclease-IN-2
<p>Cap-dependent endonuclease-IN-2 strongly blocks influenza A virus RNA polymerase; it's a CEN inhibitor.</p>Fórmula:C30H24FN3O7SCor e Forma:SolidPeso molecular:589.59PLpro-IN-5
CAS:<p>PLpro-IN-5 (compound 21), serving as a PLPro protease inhibitor, boasts an IC50 of 91.14 nM. This compound exhibits a broad-spectrum antivirus efficacy, particularly effective against SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Fórmula:C26H33N3OCor e Forma:SolidPeso molecular:403.56PptT-IN-1
<p>PptT-IN-1, a potent PptT inhibitor (IC50: 2.8 μM), shows promise for tuberculosis research.</p>Fórmula:C18H29N5O2Cor e Forma:SolidPeso molecular:347.46MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Fórmula:C16H15ClF3NCor e Forma:SolidPeso molecular:313.745Colistin adjuvant-1
<p>Colistin adjuvant-1, inhibits NF-κB (IC50: 0.209 μM), boosts mucin against gram-negative bacteria.</p>Fórmula:C16H7F9N2OCor e Forma:SolidPeso molecular:414.23QPX7728 methoxy acetoxy methy ester
CAS:<p>QPX7728 methoxy acetoxy methy ester is an inhibitor of boronic acid β-lactamase.</p>Fórmula:C14H14BFO7Pureza:98%Cor e Forma:SolidPeso molecular:324.07Flutimide
CAS:<p>Flutimide: Endonuclease inhibitor, IC50 = 3μM, for research on acute respiratory diseases like influenza.</p>Fórmula:C12H18N2O3Cor e Forma:SolidPeso molecular:238.28NS2B/NS3-IN-5
<p>Compound 25b inhibits DENV2/ZIKV NS2B/NS3 proteases; IC50: ZIKV 0.67μM, DENV2 4.38μM.</p>Fórmula:C14H9IN2O3SCor e Forma:SolidPeso molecular:412.2HCV-IN-38
<p>Potent oral HCV inhibitor HCV-IN-38 has 15 nM EC50, 431 SI, high efficacy, and low toxicity.</p>Fórmula:C22H24ClF3N4O4Cor e Forma:SolidPeso molecular:500.9Urease-IN-2
<p>Urease-IN-2 is a non-competitive inhibitor of urease (IC50: 0.94 μM, Ki: 1.6 μM) that non-competitively inhibits Jack bean urease (JBU).</p>Fórmula:C26H25N5O5S3Cor e Forma:SolidPeso molecular:583.7Antitrypanosomal agent 5
<p>Antitrypanosal agent 5 is a selective anti-trypanosomal agent that acts on T. brucei (IC50: 1 nM) and HEK293 cells (IC50: 483.3 μM).</p>Fórmula:C30H30N6O4SCor e Forma:SolidPeso molecular:570.66
