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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5400 produtos de "Neurociência"

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  • Tipindole
    Targetmol
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    Tipindole

    CAS:
    <p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>
    Fórmula:C16H20N2O2S
    Cor e Forma:Solid
    Peso molecular:304.41

    Ref: TM-T201819

  • Logotipo do CymitQuimica
    Targetmol
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    AChE-IN-5

    <p>AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.</p>
    Fórmula:C38H45N5O
    Cor e Forma:Solid
    Peso molecular:587.8

    Ref: TM-T64162

  • Logotipo do CymitQuimica
    Targetmol
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    AChE/BChE-IN-19

    CAS:
    <p>AChE/BChE-IN-19 (compound 12) is a nicotinic hydrazine derivative that acts as an inhibitor of AChE (IC50=21.45 nM) and BChE (IC50=18.42 nM), and it is applicable in Alzheimer's disease research.</p>
    Fórmula:C26H22N4O3
    Peso molecular:438.48

    Ref: TM-T209831

  • VU6016235
    Targetmol
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    VU6016235

    CAS:
    <p>VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.</p>
    Fórmula:C21H22N4OS
    Cor e Forma:Solid
    Peso molecular:378.49

    Ref: TM-T201326

  • LY3020371 hydrochloride
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    LY3020371 hydrochloride

    CAS:
    <p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>
    Fórmula:C15H16ClF2NO5S
    Cor e Forma:Solid
    Peso molecular:395.81

    Ref: TM-T11911

  • Azotomycin
    Targetmol
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    Azotomycin

    CAS:
    <p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>
    Fórmula:C17H23N7O8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:453.41

    Ref: TM-T26729

  • BACE1-IN-5
    Targetmol
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    BACE1-IN-5

    CAS:
    <p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) &amp; Aβ production (IC50: 0.82 nM), enhances hERG inhibition &amp; P-gp efflux.</p>
    Fórmula:C18H16F5N5O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:461.41

    Ref: TM-T10453

  • Flucopride
    Targetmol
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    Flucopride

    CAS:
    <p>Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.</p>
    Fórmula:C22H33FN2O2
    Cor e Forma:Solid
    Peso molecular:376.51

    Ref: TM-T201815

  • R-137696
    Targetmol
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    R-137696

    CAS:
    <p>R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.</p>
    Fórmula:C17H23N3O2
    Cor e Forma:Solid
    Peso molecular:301.38

    Ref: TM-T201501

  • Neral
    Targetmol
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    Neral

    CAS:
    <p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>
    Fórmula:C10H16O
    Cor e Forma:Solid
    Peso molecular:152.23

    Ref: TM-T201808

  • ROS151
    Targetmol
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    ROS151

    <p>ROS151 is an AChE inhibitor with IC50 values of 14 nM (hAChE), 1.68 μM (eqBChE), and 8.17 μM (hFAAH). Additionally, it acts as a chelating agent for Fe3+ and Cu2+. ROS151 is utilized in research related to Alzheimer's disease.</p>
    Fórmula:C18H18FN3O6
    Cor e Forma:Solid
    Peso molecular:391.35

    Ref: TM-T201447

  • Desmethylflunitrazepam
    Targetmol
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    Desmethylflunitrazepam

    CAS:
    <p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>
    Fórmula:C15H10FN3O3
    Cor e Forma:Solid
    Peso molecular:299.26

    Ref: TM-T201723

  • Tuclazepam
    Targetmol
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    Tuclazepam

    CAS:
    <p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>
    Fórmula:C17H16Cl2N2O
    Cor e Forma:Solid
    Peso molecular:335.23

    Ref: TM-T201570

  • Etoperidone
    Targetmol
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    Etoperidone

    CAS:
    <p>Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).</p>
    Fórmula:C19H28ClN5O
    Cor e Forma:Solid
    Peso molecular:377.91

    Ref: TM-T201838

  • γ-secretase modulator 6
    Targetmol
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    γ-secretase modulator 6

    CAS:
    <p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>
    Fórmula:C25H26N6O2
    Cor e Forma:Solid
    Peso molecular:442.513

    Ref: TM-T206107

  • CB2R/5-HT1AR agonist 1
    Targetmol
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    CB2R/5-HT1AR agonist 1

    CAS:
    <p>Compound 2o, also known as CB2R/5-HT1AR agonist 1, serves as a partial orally active agonist for the CB2 receptor (EC50 = 479.6 nM) and a full agonist for the 5-HT1A receptor (EC50 = 2.7 μM). This compound demonstrates both anti-anxiety and anti-depressive effects and has favorable pharmacokinetic properties [1].</p>
    Fórmula:C24H33NO3
    Cor e Forma:Solid
    Peso molecular:383.52

    Ref: TM-T86012

  • Aβ42 agonist-1
    Targetmol
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    Aβ42 agonist-1

    CAS:
    <p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>
    Fórmula:C15H11NO2
    Pureza:99.77%
    Cor e Forma:Solid
    Peso molecular:237.25

    Ref: TM-T85792

  • Metoquizine
    Targetmol
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    Metoquizine

    CAS:
    <p>Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.</p>
    Fórmula:C22H27N5O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:377.48

    Ref: TM-T25805

  • SB 243213 dihydrochloride
    Targetmol
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    SB 243213 dihydrochloride

    CAS:
    <p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>
    Fórmula:C22H21Cl2F3N4O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:501.33

    Ref: TM-T12859L

  • NB-360
    Targetmol
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    NB-360

    CAS:
    <p>NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.</p>
    Fórmula:C21H19F4N5O2
    Pureza:99.72%
    Cor e Forma:Solid
    Peso molecular:449.4

    Ref: TM-T12188