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Células - tronco e Derivados

Células - tronco e Derivados

Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.

Subcategorias de "Células - tronco e Derivados"

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Foram encontrados 694 produtos de "Células - tronco e Derivados"

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  • H-1152 dihydrochloride
    Targetmol
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    H-1152 dihydrochloride

    CAS:
    <p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>
    Fórmula:C16H23Cl2N3O2S
    Pureza:99.85%
    Cor e Forma:Solid
    Peso molecular:392.34

    Ref: TM-T35328

  • STAT6-IN-2
    Targetmol
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    STAT6-IN-2

    CAS:
    <p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>
    Fórmula:C28H31N5O2
    Pureza:99.67%
    Cor e Forma:Solid
    Peso molecular:469.58

    Ref: TM-T79185

  • GSK-3 inhibitor 1
    Targetmol
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Fórmula:C22H17ClFN5O2
    Pureza:98.42%
    Cor e Forma:Solid
    Peso molecular:437.85

    Ref: TM-T11468

  • LNK01004
    Targetmol
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    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Fórmula:C26H31N7O2
    Cor e Forma:Solid
    Peso molecular:473.57

    Ref: TM-T205387

  • Milpecitinib
    Targetmol
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    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Fórmula:C20H20N4O2S
    Cor e Forma:Solid
    Peso molecular:380.463

    Ref: TM-T205326

  • TYK2 ligand 2
    Targetmol
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    TYK2 ligand 2

    CAS:
    <p>TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.</p>
    Fórmula:C24H20FN7O4
    Cor e Forma:Solid
    Peso molecular:489.458

    Ref: TM-T206678

  • TEAD-IN-20
    Targetmol
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    TEAD-IN-20

    CAS:
    <p>TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.</p>
    Fórmula:C20H19F3N4O3
    Cor e Forma:Solid
    Peso molecular:420.39

    Ref: TM-T207373

  • Logotipo do CymitQuimica
    Targetmol
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    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Fórmula:C26H36FN5O2
    Cor e Forma:Solid
    Peso molecular:469.59

    Ref: TM-T63026

  • M3686
    Targetmol
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    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Fórmula:C21H18F3N5O2
    Cor e Forma:Solid
    Peso molecular:429.395

    Ref: TM-T205477

  • lirucitinib
    Targetmol
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    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Fórmula:C16H25N5OS
    Cor e Forma:Solid
    Peso molecular:335.468

    Ref: TM-T205259

  • iBFAR2
    Targetmol
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    iBFAR2

    CAS:
    <p>iBFAR2, an inhibitor of BFAR, restores the CD8+ tumor-resident memory T cell subset against solid tumors. It promotes the binding of JAK2-STAT1 and enhances the phosphorylation of STAT1.</p>
    Fórmula:C19H15F3N2O2
    Cor e Forma:Solid
    Peso molecular:360.33

    Ref: TM-T204531

  • CEE321
    Targetmol
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    CEE321

    CAS:
    <p>CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.</p>
    Fórmula:C18H16ClN5O
    Cor e Forma:Solid
    Peso molecular:353.806

    Ref: TM-T204824

  • TEAD-IN-1
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    TEAD-IN-1

    CAS:
    <p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>
    Fórmula:C15H20F2N2O3S
    Cor e Forma:Solid
    Peso molecular:346.393

    Ref: TM-T204883

  • TGFβ1-IN-1
    Targetmol
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    TGFβ1-IN-1

    CAS:
    <p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>
    Fórmula:C22H24N2O3
    Pureza:99.89% - 99.89%
    Cor e Forma:Solid
    Peso molecular:364.438

    Ref: TM-T61389

  • JAK1-IN-16
    Targetmol
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    JAK1-IN-16

    <p>JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.</p>
    Fórmula:C20H15ClF3N3OS
    Cor e Forma:Solid
    Peso molecular:437.87

    Ref: TM-T201648

  • STAT3-IN-8
    Targetmol
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    STAT3-IN-8

    CAS:
    <p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>
    Fórmula:C19H7F7N2O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:444.26

    Ref: TM-T71550

  • ROCK/HDAC-IN-1
    Targetmol
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    ROCK/HDAC-IN-1

    <p>ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.</p>
    Fórmula:C19H22N4O3S
    Cor e Forma:Solid
    Peso molecular:386.47

    Ref: TM-T201708

  • MGD-28
    Targetmol
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    MGD-28

    CAS:
    <p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>
    Fórmula:C33H34FN7O3
    Pureza:99.39%
    Cor e Forma:Solid
    Peso molecular:595.67

    Ref: TM-T201415

  • (R)-9b
    Targetmol
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    (R)-9b

    CAS:
    <p>(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.</p>
    Fórmula:C20H27ClN6O
    Cor e Forma:Solid
    Peso molecular:402.92

    Ref: TM-T201776

  • (+)-ITD-1
    Targetmol
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    (+)-ITD-1

    CAS:
    <p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>
    Fórmula:C27H29NO3
    Cor e Forma:Solid
    Peso molecular:415.52

    Ref: TM-T201672