Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase(59 produtos)
- Hedgehog/Smoothened(44 produtos)
- Via Hippo(6 produtos)
- JAK(245 produtos)
- Porcupine(9 produtos)
- ROCK(70 produtos)
- STAT(98 produtos)
- Células - tronco(486 produtos)
- TGF-beta/Smad(58 produtos)
- Wnt/beta-catenina(66 produtos)
Exibir 2 mais subcategorias
Foram encontrados 695 produtos de "Células - tronco e Derivados"
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BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Fórmula:C22H25N3OPureza:99.92%Cor e Forma:SolidPeso molecular:347.45JI051
CAS:<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44SB-772077B dihydrochloride
CAS:<p>SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).</p>Fórmula:C15H20Cl2N8O2Pureza:98%Cor e Forma:SolidPeso molecular:415.28Jaspamycin
CAS:<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Fórmula:C12H12N4O5Cor e Forma:SolidPeso molecular:292.25(Rac)-SIS3 free base
CAS:<p>SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.</p>Fórmula:C28H27N3O3Pureza:98%Cor e Forma:SolidPeso molecular:453.53GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Fórmula:C14H13N3OSPureza:98.58%Cor e Forma:SolidPeso molecular:271.34AF-2112
<p>AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.</p>Fórmula:C21H18FNO3Pureza:98%Cor e Forma:SolidPeso molecular:351.37SD-1029
CAS:<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Fórmula:C25H32Br2Cl2N2O3Cor e Forma:SolidPeso molecular:639.25FzM1.8
CAS:<p>FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.</p>Fórmula:C18H14N2O4Pureza:99.89%Cor e Forma:SolidPeso molecular:322.31LEQ506
CAS:<p>LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.</p>Fórmula:C25H32N6OPureza:99.76%Cor e Forma:SolidPeso molecular:432.56JAK1-IN-8
CAS:<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Fórmula:C14H14ClFN2O2Pureza:99.94%Cor e Forma:SolidPeso molecular:296.72IHMT-MST1-58
CAS:<p>IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.</p>Fórmula:C21H22N6O3SPureza:98.31% - 99.92%Cor e Forma:SolidPeso molecular:438.5Rho-Kinase-IN-1
CAS:<p>Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.</p>Fórmula:C20H24N4SPureza:99.8%Cor e Forma:SolidPeso molecular:352.5Butyzamide
CAS:<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Fórmula:C29H32Cl2N2O5SPureza:99.51% - 99.83%Cor e Forma:SoildPeso molecular:591.55PI-828
CAS:<p>PI-828 (LY 294002), a PI3K inhibitor, researches PI3K function and aids stem cell differentiation into mesoderm.</p>Fórmula:C19H18N2O3Pureza:99.95%Cor e Forma:SolidPeso molecular:322.36CRT0066854 hydrochloride
CAS:<p>CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.</p>Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48DIF-3
CAS:<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Fórmula:C13H17ClO4Pureza:99.57%Cor e Forma:SolidPeso molecular:272.72CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Fórmula:C17H13N3O3SPureza:99.6%Cor e Forma:SolidPeso molecular:339.37EHT 1610
CAS:<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Fórmula:C18H14FN5O2SPureza:98.59%Cor e Forma:SolidPeso molecular:383.4BIP-135
CAS:<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Fórmula:C21H13BrN2O3Pureza:99.93%Cor e Forma:SolidPeso molecular:421.24JAK-STAT-IN-1
CAS:<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Fórmula:C21H21N5O2Pureza:99.59%Cor e Forma:SolidPeso molecular:375.42GSK-3β inhibitor 11
CAS:<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Fórmula:C20H15N3O4SPureza:97.33%Cor e Forma:SolidPeso molecular:393.42Miclxin
CAS:<p>Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent</p>Fórmula:C26H27N5O2Pureza:99.17% - 99.99%Cor e Forma:SolidPeso molecular:441.52Wnt/β-catenin agonist 4
CAS:<p>Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.</p>Fórmula:C16H15FN4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:314.31LM-41
CAS:<p>LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.</p>Fórmula:C19H14FNO2Pureza:99.73%Cor e Forma:SolidPeso molecular:307.32Casein kinase 1δ-IN-1
CAS:<p>Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.</p>Fórmula:C11H7N3OSPureza:99.46%Cor e Forma:SolidPeso molecular:229.26GSK-3 Inhibitor XIII
CAS:<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Fórmula:C18H15N5Pureza:99.85% - 99.86%Cor e Forma:SolidPeso molecular:301.35ARN25068
CAS:<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Fórmula:C19H18N6SPureza:99.75%Cor e Forma:SolidPeso molecular:362.45GSK-3β inhibitor 2
CAS:<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Fórmula:C14H14N4O3SPureza:99.08%Cor e Forma:SolidPeso molecular:318.35Rhodblock 6
CAS:<p>Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.</p>Fórmula:C12H13N3OPureza:98.27%Cor e Forma:SolidPeso molecular:215.25XL413 xHCl
CAS:<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Fórmula:C14H12ClN3O2·xHClPureza:99.37% - 99.67%Cor e Forma:SolidPeso molecular:326.18STS-E412
CAS:<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Fórmula:C15H15ClN4O2Pureza:99.01%Cor e Forma:SolidPeso molecular:318.76AS 1892802
CAS:<p>AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.</p>Fórmula:C20H19N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:333.38ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Fórmula:C18H14N4OSPureza:98.92%Cor e Forma:SolidPeso molecular:334.39Izencitinib
CAS:<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50TT-10
CAS:<p>TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.</p>Fórmula:C11H10FN3OS2Pureza:99.29%Cor e Forma:SolidPeso molecular:283.35FzM1
CAS:<p>FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)</p>Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Cor e Forma:SolidPeso molecular:360.43MSC-4106
CAS:<p>MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.</p>Fórmula:C18H12F3N3O2Pureza:99.89%Cor e Forma:SoildPeso molecular:359.3A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Fórmula:C17H13F3N4O2Pureza:99.9%Cor e Forma:SolidPeso molecular:362.31STAT6-IN-3
CAS:<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Fórmula:C32H35IN3O7PPureza:98%Cor e Forma:SolidPeso molecular:731.51Antitumor agent-73
CAS:<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Fórmula:C50H82BrO4PPureza:98%Cor e Forma:SolidPeso molecular:858.06Casein kinase 1δ-IN-5
CAS:<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Fórmula:C16H11F3N2OSPureza:98%Cor e Forma:SolidPeso molecular:336.33YAP-TEAD-IN-2
CAS:<p>YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)</p>Fórmula:C25H24ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:470.92JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Fórmula:C21H19N7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:465.55Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:7673,7-DMF
CAS:<p>3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.</p>Fórmula:C17H14O4Pureza:98%Cor e Forma:SolidPeso molecular:282.29BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Fórmula:C20H23N3OPureza:99.89%Cor e Forma:SolidPeso molecular:321.42JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Fórmula:C33H38F2N6O8Cor e Forma:SolidPeso molecular:684.69Tyk2-IN-9
CAS:<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Fórmula:C20H17N9Pureza:98%Cor e Forma:SolidPeso molecular:383.41
