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Tirosina Quinase/Adaptador

Tirosina Quinase/Adaptador

Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.

Subcategorias de "Tirosina Quinase/Adaptador"

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Foram encontrados 1375 produtos de "Tirosina Quinase/Adaptador"

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  • EGFR-IN-159
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Fórmula:C21H23N3O5
    Cor e Forma:Solid
    Peso molecular:397.424

    Ref: TM-T206989

  • EGFR-IN-38
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Fórmula:C25H24ClN7O2
    Cor e Forma:Solid
    Peso molecular:489.96

    Ref: TM-T63283

  • EGFR-IN-125
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Fórmula:C30H26N8O
    Cor e Forma:Solid
    Peso molecular:514.58

    Ref: TM-T204450

  • Logotipo do CymitQuimica
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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Fórmula:C31H30FN7O
    Cor e Forma:Solid
    Peso molecular:535.61

    Ref: TM-T63774

  • HER2-IN-7
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Fórmula:C28H26F3N7O3
    Cor e Forma:Solid
    Peso molecular:565.55

    Ref: TM-T64003

  • EGFR-IN-34
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    EGFR-IN-34

    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Fórmula:C26H27ClN6O2
    Cor e Forma:Solid
    Peso molecular:490.98

    Ref: TM-T63300

  • Sacibertinib
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    Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Fórmula:C32H31ClN6O4
    Cor e Forma:Solid
    Peso molecular:599.08

    Ref: TM-T64225

  • VEGFR2-IN-1
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    VEGFR2-IN-1

    CAS:
    <p>VEGFR2-IN-1 is a VEGFR2 inhibitor with antitumor activity used in the study of breast cancer.</p>
    Fórmula:C22H18N6S
    Pureza:98.15%
    Cor e Forma:Solid
    Peso molecular:398.48

    Ref: TM-T61899

  • Logotipo do CymitQuimica
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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Fórmula:C16H16N4O2S
    Cor e Forma:Solid
    Peso molecular:328.39

    Ref: TM-T60938

  • Tesevatinib tosylate
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Fórmula:C31H33Cl2FN4O5S
    Cor e Forma:Solid
    Peso molecular:663.59

    Ref: TM-T201865

  • Logotipo do CymitQuimica
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    DDR1-IN-8

    CAS:
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Fórmula:C23H24F3N5O2
    Peso molecular:459.46

    Ref: TM-T209082

  • Logotipo do CymitQuimica
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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Fórmula:C19H14BrF3N2O
    Cor e Forma:Solid
    Peso molecular:423.23

    Ref: TM-T62271

  • BNN-20
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    BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Fórmula:C20H30O2
    Cor e Forma:Solid
    Peso molecular:302.45

    Ref: TM-T201864

  • EGFR-IN-135
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    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Fórmula:C12H14N4OS2
    Cor e Forma:Solid
    Peso molecular:294.4

    Ref: TM-T201484

  • Logotipo do CymitQuimica
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    c-Fms-IN-15

    CAS:
    <p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>
    Fórmula:C29H28F3N7O2
    Peso molecular:563.57

    Ref: TM-T210059

  • Logotipo do CymitQuimica
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    Protein kinase inhibitor 4

    CAS:
    <p>Protein kinase inhibitor 4 (Compound 3) is a chemical that acts as a protein kinase inhibitor, specifically targeting TRK-A with an IC50 of 3.0 nM, and ROS1 with an IC50 of 104 nM.</p>
    Fórmula:C25H24F2N6O3S
    Peso molecular:526.56

    Ref: TM-T209488

  • BML-265
    Targetmol
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Fórmula:C18H15N3O2
    Cor e Forma:Solid
    Peso molecular:305.331

    Ref: TM-T204769

  • EGFR/VEGFR2-IN-2
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Fórmula:C24H15FO3
    Cor e Forma:Solid
    Peso molecular:370.37

    Ref: TM-T201505

  • CL-A3-7
    Targetmol
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    CL-A3-7

    CAS:
    <p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>
    Fórmula:C24H22Br2F2N2O3
    Cor e Forma:Solid
    Peso molecular:584.25

    Ref: TM-T201641

  • 2-Methyl-3-phenylquinoxaline
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    2-Methyl-3-phenylquinoxaline

    CAS:
    <p>2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).</p>
    Fórmula:C15H12N2
    Cor e Forma:Solid
    Peso molecular:220.27

    Ref: TM-T201514