Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Aliskiren hydrochloride
CAS:<p>Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is a selective, orally active, renin inhibitor (IC50: 1.5 nM). Cachexia.</p>Fórmula:C30H54ClN3O6Cor e Forma:SolidPeso molecular:588.23Nesolicaftor
CAS:<p>Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.</p>Fórmula:C18H18N4O4Pureza:99.79%Cor e Forma:SolidPeso molecular:354.36Hoechst 33342 trihydrochloride
CAS:<p>Hoechst 33342 trihydrochloride (bisBenzimide H 33342 trihydrochloride;HOE 33342 trihydrochloride) is a membrane permeant DNA stain with blue fluorescence.</p>Fórmula:C27H31Cl3N6OPureza:98.73% - ≥98%Cor e Forma:SolidPeso molecular:561.93SN-38
CAS:<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Fórmula:C22H20N2O5Pureza:98% - 99.97%Cor e Forma:Light-Yellow SolidPeso molecular:392.4BL-918
CAS:<p>BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.</p>Fórmula:C23H15F8N3OSPureza:99.4% - 99.89%Cor e Forma:SolidPeso molecular:533.44SBI-0206965
CAS:<p>SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.</p>Fórmula:C21H21BrN4O5Pureza:99.13%Cor e Forma:SolidPeso molecular:489.32Crenolanib
CAS:<p>Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).</p>Fórmula:C26H29N5O2Pureza:98.40% - 99.73%Cor e Forma:SolidPeso molecular:443.54TPEN
CAS:<p>TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.</p>Fórmula:C26H28N6Pureza:98% - 99.72%Cor e Forma:White Crystalline PowderPeso molecular:424.54AG490
CAS:<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Cor e Forma:Yellow SolidPeso molecular:294.3PF-06454589
CAS:<p>PF-06454589 is a potent inhibitor of LRRK2.</p>Fórmula:C14H16N6OPureza:99.06%Cor e Forma:SolidPeso molecular:284.32Lumacaftor
CAS:<p>Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.</p>Fórmula:C24H18F2N2O5Pureza:99.48% - 99.68%Cor e Forma:SolidPeso molecular:452.41ULK-101
CAS:<p>ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.</p>Fórmula:C22H16F4N4OSPureza:97.55% - 99.94%Cor e Forma:SolidPeso molecular:460.45Regorafenib mesylate
CAS:<p>Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.</p>Fórmula:C22H19ClF4N4O6SCor e Forma:SolidPeso molecular:578.92MLN9708 analogues
CAS:<p>MLN2238 inhibits 20S proteasome's β5 site (Ki50=0.93 nM, IC50=3.4 nM), active form of Ixazomib Citrate in solutions/plasma.</p>Fórmula:C20H23BCl2N2O9Pureza:98.24% - 99.23%Cor e Forma:SolidPeso molecular:517.12Tepotinib hydrochloride(1 : x)
CAS:<p>Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14</p>Fórmula:C29H29ClN6O2Pureza:99.81%Cor e Forma:SolidPeso molecular:529.04Degrasyn
CAS:<p>Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.</p>Fórmula:C19H18BrN3OPureza:98.32% - 99.98%Cor e Forma:SolidPeso molecular:384.27Trifluoperazine
CAS:<p>Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.</p>Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:407.5E-64
CAS:<p>E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.</p>Fórmula:C15H27N5O5Pureza:98% - 99.95%Cor e Forma:White SolidPeso molecular:357.41Paeonol
CAS:<p>Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.</p>Fórmula:C9H10O3Pureza:98.55% - 99.56%Cor e Forma:White To Beige Crystalline PowderPeso molecular:166.17RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Fórmula:C17H20N4O2Pureza:99.30%Cor e Forma:SolidPeso molecular:312.37
