Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
FAAH-IN-1
CAS:<p>FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.</p>Fórmula:C20H19ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:398.91GPP78
CAS:<p>GPP78: Strong Nampt inhibitor, IC50 3.0 nM, depletes NAD. Kills SH-SY5Y cells, IC50 3.8 nM via autophagy. Anti-cancer and anti-inflammatory.</p>Fórmula:C27H29N5OPureza:98%Cor e Forma:SolidPeso molecular:439.553HOI-BA-01
CAS:<p>3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.</p>Fórmula:C19H15NO5Pureza:98%Cor e Forma:SolidPeso molecular:337.33rac-NBI-74330
CAS:<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Fórmula:C32H27F4N5O3Pureza:99.6%Cor e Forma:SolidPeso molecular:605.58ACT-660602
CAS:<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Fórmula:C20H20F6N8OSCor e Forma:SolidPeso molecular:534.48DK-1-49
CAS:<p>DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.</p>Fórmula:C28H31N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:549.71AMG 487 (S-enantiomer)
CAS:<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59SR12418
CAS:<p>SR12418 is a specific synthetic ligand for REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. inhibits IL-17A expression in EL4 cells.</p>Fórmula:C31H30FNO3Pureza:99.96%Cor e Forma:SolidPeso molecular:483.57VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Fórmula:C19H13BrCl4N2O2Pureza:98%Cor e Forma:SolidPeso molecular:523.03(R)-Hydroxychloroquine
CAS:<p>(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.</p>Fórmula:C18H26ClN3OPureza:98%Cor e Forma:SolidPeso molecular:335.87AC-73
CAS:<p>AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.</p>Fórmula:C21H21NO2Pureza:98.95%Cor e Forma:SolidPeso molecular:319.4Atg4B-IN-2
CAS:<p>Atg4B-IN-2 is an Atg4B inhibitor with anticancer activity that inhibits Atg4B and PLA2 and resists the anticancer activity of resistant prostate cancer drugs.</p>Fórmula:C21H30O3Pureza:98.86%Cor e Forma:SolidPeso molecular:330.46GC7 Sulfate
CAS:<p>GC7 Sulfate blocks DHS, the sole enzyme activating eIF5A2, thus preventing eIF5A2 activation.</p>Fórmula:C8H22N4O4SPureza:99.85% - >99.99%Cor e Forma:SolidPeso molecular:270.35NUCC-390
CAS:<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Fórmula:C23H33N5OPureza:97.08%Cor e Forma:SolidPeso molecular:395.54Rosolutamide
CAS:<p>Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.</p>Fórmula:C28H32O6Pureza:95.48% - 99.15%Cor e Forma:SolidPeso molecular:464.55Apostatin-1
CAS:<p>Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.</p>Fórmula:C19H27N3OSPureza:99.31%Cor e Forma:SolidPeso molecular:345.5CCT020312
CAS:<p>CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.</p>Fórmula:C31H30Br2N4O2Pureza:98.63%Cor e Forma:SolidPeso molecular:650.4CP-312
CAS:<p>CP-312 activates antioxidant defense, induces HMOX1, and shields human iPSC-derived cardiomyocytes from oxidative stress.</p>Fórmula:C16H12ClN3OS2Pureza:99.61%Cor e Forma:SolidPeso molecular:361.87Acetazolamide sodium
CAS:<p>Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.</p>Fórmula:C4H5N4NaO3S2Pureza:99.71% - 99.87%Cor e Forma:SolidPeso molecular:244.23MAPK13-IN-1
CAS:<p>MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).</p>Fórmula:C20H23N5O2Pureza:99.62%Cor e Forma:SolidPeso molecular:365.43
