Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Tigecycline-d9
CAS:<p>Tigecycline-d9 is a deuterated compound of Tigecycline. Tigecycline has a CAS number of 220620-09-7. Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.</p>Fórmula:C29H30D9N5O8Cor e Forma:SolidPeso molecular:594.70Lovastatin-d3
CAS:<p>Lovastatin-d3 is a deuterated compound of Lovastatin. Lovastatin has a CAS number of 75330-75-5. Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.</p>Fórmula:C24H33D3O5Cor e Forma:SolidPeso molecular:407.56VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Cor e Forma:SolidPeso molecular:404.32MK-5108
CAS:<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Fórmula:C22H21ClFN3O3SPureza:99.22%Cor e Forma:SolidPeso molecular:461.94Bexarotene
CAS:<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>Fórmula:C24H28O2Pureza:99% - 99.65%Cor e Forma:White SolidPeso molecular:348.48Alisol A
CAS:<p>Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.</p>Fórmula:C30H50O5Pureza:99.77% - 99.94%Cor e Forma:SolidPeso molecular:490.71Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:428.44Atorvastatin
CAS:<p>Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.</p>Fórmula:C33H35FN2O5Pureza:99.37% - 99.69%Cor e Forma:SolidPeso molecular:558.64BGT226 maleate
CAS:<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.78%Cor e Forma:SolidPeso molecular:650.6Brivanib (alaninate)
CAS:<p>Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.</p>Fórmula:C22H24FN5O4Pureza:99.46% - 99.66%Cor e Forma:SolidPeso molecular:441.46Rac-Efavirenz
CAS:<p>Rac-Efavirenz is a non stereospecific structure of Efavirenz.</p>Fórmula:C14H9ClF3NO2Cor e Forma:SolidPeso molecular:315.67Chloroquine dihydrochloride
CAS:<p>Chloroquine: treats malaria, amebiasis, rheumatoid arthritis, lupus; works by inhibiting parasites in red blood cells.</p>Fórmula:C18H27Cl2N3Cor e Forma:SolidPeso molecular:356.33Metyrapone Tartrate
CAS:<p>Metyrapone Tartrate: a test inhibitor for diagnosing Cushing's; blocks steroid 11-beta-hydroxylase.</p>Fórmula:C22H26N2O13Cor e Forma:SolidPeso molecular:526.45Euchrysine 3RX
CAS:<p>Euchrysine 3RX is an agent of bioactive chemicals.</p>Fórmula:C20H26BrCl2N3OPureza:98%Cor e Forma:Brown PowderPeso molecular:475.25Pravastatin
CAS:<p>Pravastatin reduces lipoproteins by blocking HMG-CoA reductase and VLDL synthesis.</p>Fórmula:C23H36O7Pureza:98%Cor e Forma:White PowderPeso molecular:424.53Resveratrol analog 2
CAS:<p>Resveratrol analog 2 mimics Resveratrol, a natural antioxidant with anti-inflammatory, cardioprotective, and anticancer benefits.</p>Fórmula:C16H13FO3Pureza:98%Cor e Forma:SolidPeso molecular:272.27YT-8-8
CAS:<p>YT-8-8 is a ligand for the p62-ZZ domain and can activate p62-dependent selective autophagy. This compound is also applicable in AUTOTAC design.</p>Fórmula:C18H23FN2O2Cor e Forma:SolidPeso molecular:318.39Erlotinib mesylate
CAS:<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Fórmula:C23H27N3O7SPureza:98%Cor e Forma:SolidPeso molecular:489.54Esmolol hydrochloride
CAS:<p>Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.</p>Fórmula:C16H25NO4·HClPureza:98.72% - 99.48%Cor e Forma:White SolidPeso molecular:331.15TAMRA alkyne, 6-isomer
CAS:<p>TAMRA alkyne, 6-isomer: a xanthene dye linker with orange emission, used for DNA/RNA labeling, reacts via Click Chemistry.</p>Fórmula:C28H25N3O4Cor e Forma:SolidPeso molecular:467.52Gavilimomab
CAS:<p>Gavilimomab(ABX-CBL) is a murine-derived IgM monoclonal antibody against CD147 antigen used in immunosuppressive treatments for glucocorticoid-resistant GVHD).</p>Pureza:95%Cor e Forma:LiquidPBA-1105
CAS:<p>PBA-1105, an autophagy-targeting chimeric molecule (AUTOTAC), facilitates the self-oligomerization of p62. Additionally, PBA-1105 enhances the autophagic flux of Ub-conjugated aggregates.</p>Fórmula:C39H48N2O6Cor e Forma:SolidPeso molecular:640.81Seriniquinone
CAS:<p>Seriniquinone is a selective agent of anticancer that acts by inducing cell death via autophagocytosis and targeting the cancer-protective protein dermcidin.</p>Fórmula:C20H8O4SPureza:98%Cor e Forma:SolidPeso molecular:344.34Paroxetine hydrochloride hemihydrate
CAS:<p>Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).</p>Fórmula:C38H44Cl2F2N2O7Pureza:99.949%Cor e Forma:SolidPeso molecular:749.67SU11274
CAS:<p>SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.</p>Fórmula:C28H30ClN5O4SPureza:98.62% - 99.53%Cor e Forma:Orange PowderPeso molecular:568.09Metofenazate
CAS:<p>Metofenazate is an selective inhibitor of calmodulin .</p>Fórmula:C31H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:598.15CXCR3 Antagonist 6c
CAS:<p>CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.</p>Fórmula:C30H32Cl3N5O3Cor e Forma:SolidPeso molecular:616.97Momelotinib Mesylate
CAS:<p>Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>Fórmula:C24H26N6O5SPureza:98%Cor e Forma:SolidPeso molecular:510.57MF-095
CAS:<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Fórmula:C27H31N3O4SCor e Forma:SolidPeso molecular:493.62(3S,5R)-Rosuvastatin
CAS:<p>(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Cor e Forma:SolidPeso molecular:481.54p38 MAPK-IN-2
CAS:<p>p38 MAPK-IN-2 is an inhibitor of p38 kinase.</p>Fórmula:C20H19ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:415.85HF50731
CAS:<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Fórmula:C26H46N4Cor e Forma:SolidPeso molecular:414.67ATG7-IN-2
CAS:<p>ATG7-IN-2 inhibits ATG7 protein with 0.089 μM IC50 and suppresses autophagy marker LC3B.</p>Fórmula:C11H16N6O7SCor e Forma:SolidPeso molecular:376.35GLPG2451
CAS:<p>GLPG2451 potentiates F508del CFTR at low temp (EC50: 11.1 nM), aiding cystic fibrosis treatment.</p>Fórmula:C16H16F3N3O5SCor e Forma:SolidPeso molecular:419.38SMER18
CAS:<p>SMER18, a small molecule enhancer of rapamycin, acts as an mTOR-independent inducer of autophagy and can be used to study neurodegenerative diseases.</p>Fórmula:C16H14ClNO2Pureza:97.27%Cor e Forma:SolidPeso molecular:287.74Omeprazole Sodium
CAS:<p>Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.</p>Fórmula:C17H18N3NaO3SPureza:99.84%Cor e Forma:Clear In WaterPeso molecular:367.4Ivacaftor hydrate
CAS:<p>Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.</p>Fórmula:C24H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:410.514CXCR4 antagonist 5
CAS:<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Poloppin
CAS:<p>Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.</p>Fórmula:C20H15BrF3NO2Pureza:98%Cor e Forma:SolidPeso molecular:438.24PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Fórmula:C17H14FN5OCor e Forma:SolidPeso molecular:323.32Ivacaftor benzenesulfonate
CAS:<p>Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.</p>Fórmula:C30H34N2O6SPureza:98%Cor e Forma:SolidPeso molecular:550.67eIF4A3-IN-2
CAS:<p>eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.</p>Fórmula:C25H19Br2ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:602.71Ralimetinib
CAS:<p>Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).</p>Fórmula:C24H29FN6Pureza:99.16% - 99.21%Cor e Forma:SolidPeso molecular:420.53PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SCor e Forma:SolidPeso molecular:368.41Lamotrigine isethionate
CAS:<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Fórmula:C11H13Cl2N5O4SCor e Forma:SolidPeso molecular:382.22SR 3677 dihydrochloride
CAS:<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Fórmula:C22H26Cl2N4O4Cor e Forma:SolidPeso molecular:481.37NSC 33994
CAS:<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Fórmula:C28H42N2O2Pureza:98%Cor e Forma:SolidPeso molecular:438.65CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Cor e Forma:SolidPeso molecular:428.53SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Fórmula:C26H21BrN2O4Cor e Forma:SolidPeso molecular:505.36Quinacrine analog 34
CAS:<p>Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.</p>Fórmula:C20H27ClN4Cor e Forma:SolidPeso molecular:358.91
