Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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Norswertianin
CAS:<p>Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.</p>Fórmula:C13H8O6Cor e Forma:SolidPeso molecular:260.2ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Fórmula:C10H8F3N3OSCor e Forma:SolidPeso molecular:275.25SB-332235
CAS:<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Fórmula:C13H10Cl3N3O4SCor e Forma:SolidPeso molecular:410.66Autophagy-IN-C1
CAS:<p>Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.</p>Fórmula:C29H28F6N4O2Cor e Forma:SolidPeso molecular:578.55Olacaftor
CAS:<p>Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).</p>Fórmula:C29H34FN3O4SCor e Forma:SolidPeso molecular:539.66PF 750
CAS:<p>PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.</p>Fórmula:C22H23N3OPureza:99.87%Cor e Forma:SolidPeso molecular:345.44AMD 3465
CAS:<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Fórmula:C24H38N6Pureza:98%Cor e Forma:SolidPeso molecular:410.60VUF11211
CAS:<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Fórmula:C26H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:504.49AUTEN-67
CAS:<p>AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.</p>Fórmula:C23H14N4O6SCor e Forma:SolidPeso molecular:474.45LV-320
CAS:<p>LV-320, potent ATG4B inhibitor; IC50: 24.5 μM, Kd: 16 μM. Blocks autophagy, stable, non-toxic, active in vivo. Useful for ATG4B research in cancer.</p>Fórmula:C29H26ClNO2S2Pureza:98%Cor e Forma:SolidPeso molecular:520.11Antiproliferative agent-5
CAS:<p>Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.</p>Fórmula:C28H21BrN8OSCor e Forma:SolidPeso molecular:597.49CXCR4 antagonist 9
CAS:<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Fórmula:C21H27FN6Cor e Forma:SolidPeso molecular:382.48SA 47
CAS:<p>SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.</p>Fórmula:C17H26N4O3Pureza:98%Cor e Forma:SolidPeso molecular:334.41CXCR4 antagonist 8
CAS:<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Fórmula:C21H26N6Cor e Forma:SolidPeso molecular:362.47ALLO-1
CAS:<p>ALLO-1, vital for autophagy, aids in engulfing paternal organelles by binding to worm LC3, LGG-1, via its LIR motif.</p>Fórmula:C17H15ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:314.77Obatoclax
CAS:<p>Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.</p>Fórmula:C20H19N3OPureza:99.44%Cor e Forma:SolidPeso molecular:317.38Nicodicosapent
CAS:<p>Nicodicosapent is a fatty acid niacin conjugate that inhibits SREBP, a regulator of cholesterol metabolism.</p>Fórmula:C28H39N3O2Pureza:98%Cor e Forma:SolidPeso molecular:449.63STK683963
CAS:<p>STK683963 activates ATG4B, mediates redox regulation, and aids cancer research.</p>Fórmula:C12H8FN3O2SCor e Forma:SolidPeso molecular:277.27LS2265
CAS:<p>LS2265, a fenofibrate derivative with a taurine modification, effectively induces the proliferation of peroxisomes in rat liver cells.</p>Fórmula:C19H20ClNO6SPureza:98%Cor e Forma:SolidPeso molecular:425.88AGN 205327
CAS:<p>AGN 205327 is a potent synthetic RAR agonist,showing selective RAR activation without RXR inhibition for retinoid research.</p>Fórmula:C24H26N2O3Pureza:99.45% - 99.71%Cor e Forma:SolidPeso molecular:390.47
