Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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HF51116
CAS:<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Fórmula:C29H46N8OCor e Forma:SolidPeso molecular:522.73CC214-2
CAS:<p>CC214-2: strong dual mTORC1/2 inhibitor, blocks autophagy, may shorten TB duration.</p>Fórmula:C20H25N5O3Cor e Forma:SolidPeso molecular:383.44AS1708727
CAS:<p>AS1708727 inhibits Foxo1, reducing blood sugar and triglycerides by altering gene expression.</p>Fórmula:C24H24Cl2N2O2Cor e Forma:SolidPeso molecular:443.37Aliskiren fumarate
CAS:<p>Oral renin inhibitor Aliskiren fumarate treats hypertension; IC50: 1.5 nM. Useful for cardiovascular and cancer cachexia research.</p>Fórmula:C34H57N3O10Cor e Forma:SolidPeso molecular:667.83Rimacalib
CAS:<p>Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).</p>Fórmula:C22H23FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:394.44Elliptinium acetate
CAS:<p>Elliptinium acetate (NSC 264137), a cytotoxic DNA intercalator for cancer research, targets L1210 cells.</p>Fórmula:C20H20N2O3Cor e Forma:SolidPeso molecular:336.38SA72
CAS:<p>SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).</p>Fórmula:C21H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:402.44SX-517
CAS:<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Fórmula:C19H16BFN2O3SCor e Forma:SolidPeso molecular:382.22TN-14003
CAS:<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42RNF5 inhibitor inh-02
CAS:<p>RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR cystic fibrosis (CF).</p>Fórmula:C23H20N4SPureza:99.23%Cor e Forma:SolidPeso molecular:384.5(S)-Hydroxychloroquine
CAS:<p>(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.</p>Fórmula:C18H26ClN3OPureza:98%Cor e Forma:SolidPeso molecular:335.87IZCZ-3
CAS:<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Fórmula:C46H49N7OPureza:98%Cor e Forma:SolidPeso molecular:715.93KRH-1636
CAS:<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Fórmula:C32H37N7O2Cor e Forma:SolidPeso molecular:551.68Autophagy inducer 4
CAS:<p>Autophagy inducer 4, a Magnolol-based Mannich derivative, is an anticancer agent that blocks cancer cell migration & is 76x more toxic to T47D cells.</p>Fórmula:C32H37NO6Cor e Forma:SolidPeso molecular:531.64PX20606 trans racemate
CAS:<p>PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).</p>Fórmula:C29H22Cl3NO4Pureza:98%Cor e Forma:SolidPeso molecular:554.85Antitumor agent-81
CAS:<p>Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.</p>Fórmula:C19H19N7O3Cor e Forma:SolidPeso molecular:393.4MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Fórmula:C34H44F6N4O7Cor e Forma:SolidPeso molecular:734.73IT1t
CAS:<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Fórmula:C21H34N4S2Pureza:98%Cor e Forma:SolidPeso molecular:406.65Amsacrine
CAS:<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Fórmula:C21H19N3O3SPureza:99.2%Cor e Forma:Yellow Crystalline Powder SolidPeso molecular:393.46CUR5g
CAS:<p>CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.</p>Fórmula:C22H20N2O2Pureza:98.92%Cor e Forma:SolidPeso molecular:344.41
