Antibiótico

<p>L-Azatyrosine from Streptomyces chibaensis is an antitumor antibiotic reversing Ras-transformed cell behavior.</p>

<p>Deacetylcephalothin Sodium Salt is an impurity in the synthesis of Cefalonium. It used as a long-acting intramammary cerate for the infusion of dairy cows.</p>

<p>Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.</p>

<p>Tauroxicum (Taurox) is formulated by COBAT to reduce fatigue and improve quality of life.</p>

<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>

<p>Sinafloxacin Mesylate is a quinolone antibiotic potentially for the treatment of bacterial infections.</p>

<p>N4Py is a good synthetic mimic of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.</p>

<p>Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.</p>

<p>Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.</p>

<p>Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.</p>

<p>RMI 10874 is a tilorone analogue. Tilorone is an orally bioavailable antiviral agent.</p>

<p>Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.</p>

<p>Albitiazolium bromide is an antimalarial compound disrupting phosphatidylcholine biosynthesis in Plasmodium, transported via NPP and cation carriers.</p>

<p>CRK12-IN-1: strong inhibitor of CRK12, kills T.b. brucei &amp; T. congolense (EC50s: 1.3 &amp; 18 nM).</p>

<p>Rosaramicin, a lipid-soluble basic macrolide, is an antibacterial substance similar to erythromycin but with a better activity against Gram-negative bacteria.</p>

<p>Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase &amp; orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).</p>

<p>Lincophenicol is an Escherichia coli ribosomal peptidyltransferase-catalyzed puromycin reaction inhibitor.</p>

<p>AFK-108 is a fungicide agent.</p>

<p>Phenosulfazole is a potent antiviral agent which has the potential for the research of poliomyelitis virus [1].</p>

<p>Vidarabine phosphate is an adenosine monophosphate analog.</p>

<p>MptpB-IN-1: orally active, potent MptpB inhibitor; reduces drug-resistant tuberculosis.</p>

<p>Chitin synthase inhibitor 4: a CHS inhibitor with antimicrobial properties, potential fungicide.</p>

<p>SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.</p>

<p>Ormetoprim (Ro 5-9754), an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.</p>

<p>SSJ-183 is a low-toxicity and orally available and anti-malarial drug with an IC50 = 7.6 nM against P. falciparum and no lethality at doses up to 2000 mg/kg po.</p>

<p>Linogliride fumarate, a guanidine derivative, stimulates insulin release by blocking ATP-sensitive K+ channels, enhancing glucose tolerance.</p>

<p>Pyrrofolic acid shows high anti-folate biological activity for S. faecalis.</p>

<p>Tunicamine is a reversible polyprenol-phosphate inhibitor.</p>

<p>Chitin synthase inhibitor 2 (2b) has an IC50 of 0.09 mM, K i 0.12 mM, shows in vitro antimicrobial activity and boosts fluconazole/polyoxin B.</p>

<p>Alalevonadifloxacin HCl is a novel l-alanine ester prodrug of levonadifloxacin.</p>

<p>Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.</p>

<p>Exeporfinium chloride(XF-73) is an antimicrobial agent that can weaken bacterial cell walls.</p>

<p>Epirubicin, a doxorubicin derivative, is an antineoplastic, inhibits topoisomerase, DNA/RNA synthesis, and Foxp3, reducing T cell activity.</p>

<p>Linogliride: a guanidine derivative, inhibits insulin release, and enhances glucose tolerance by blocking ATP-sensitive K+ channels in pancreatic beta cells.</p>

<p>Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.</p>

<p>Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.</p>

<p>FR900098, a fosmidomycin derivative, has potent antimalarial effects, targeting DOXP reductoisomerase and eradicating P. vinckei in mice at &gt;10 mg/kg.</p>

<p>Abimtrelvir exhibited antiviral activity.</p>

<p>Xenalamine is a synthetic compound of antiviral.</p>

<p>DDD01035881 is a anti-malarial drug that blocks parasite-to-mosquito transmission by targeting the Plasmodium vesicle membrane protein Pfs16.</p>

<p>LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.</p>

<p>Acyclovir monophosphate, a strong anti-HSV agent, inhibits viral DNA polymerase, blocking DNA synthesis and chain elongation.</p>

<p>S 863390 is a renin inhibitor.</p>

<p>Riodoxol is an antiviral agent that effectively affects the reproduction and maturation of viruses.</p>

<p>Amcinafal is an active diol,and used against virus replication and interferon production.</p>

<p>Compound 5, an antiviral agent, effectively targets murine norovirus, with potential in infectious disease and oncology research.</p>

<p>Saquayamycin B, a glycoside, targets Gram-positive bacteria and both adriamycin-sensitive and -resistant P388 leukemia cells.</p>

<p>BRD-8000.3 is a narrow-spectrum antimycobacterial targeting EfpA, inhibiting lipid transport in drug-tolerant Mtb and useful in structural and functional.</p>

<p>4-((4-((4-Aminophenyl)sulfonyl)phenyl)amino)-4-oxobutanoic acid is a sulfonamide compound that can be used as an anti infective agent [1].</p>

<p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>

<p>Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.</p>

<p>Nortopixantrone HCl (BBR 3438) is a novel 9-azacyclonopyrazole that shows antitumor activity in a human prostate cancer model.</p>

<p>Quinupristin, a macrolide-lincosamide-streptogramin antibiotic, inhibits protein synthesis in bacteria.</p>

<p>Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.</p>

<p>Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.</p>

<p>Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.</p>

<p>Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.</p>

<p>OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M.</p>

<p>Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).</p>

<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>

<p>Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated</p>

<p>β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.</p>

<p>Compound 6d (Antibacterial agent 159) is an antibiotic effective against impetigo and Clostridium difficile infection (CDI), with no observed recurrence for CDI</p>

<p>S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.</p>

<p>Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity.</p>

<p>Pristinamycin IA (Mikamycin B) is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.</p>

<p>Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.</p>

<p>SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an</p>

<p>AS-2077715, an antifungal agent, exhibits inhibitory activity against Trichophyton species and is derived from the fermentation broth of Capnodium sp. 339855. It is utilized in the study of fungal infections [1].</p>

<p>4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].</p>

<p>Aranciamycin (Compound 1), an anthracycline antibiotic, exhibits collagenase inhibitory activity (IC50 3.7*10^-7 M) and can inhibit DNA synthesis in tumor cells</p>

<p>CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].</p>

<p>DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.</p>

<p>Berkeleylactone E, a macrolide antibiotic [1], exhibits antimicrobial properties.</p>

<p>Myxopyronin A is an inhibitor of bacterial RNA polymerase.</p>

<p>Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.</p>

<p>N-Acetylpurinomycin is a selective agonist of CB2 receptor.</p>

<p>Oseltamivir acid methyl ester, a CES1-convertible neuraminidase inhibitor, serves as an antiviral prodrug.</p>

<p>Annamycin, a semi-synthetic doxorubicin derivative, binds DNA, blocks topoisomerase II, and evades MDR, inhibiting DNA/RNA/protein synthesis.</p>

<p>Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.</p>

<p>N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) serves as an autoregulator for carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048 and induces the expression of rhiI in R. leguminosarum [1].</p>

<p>Alatrofloxacin is a prodrug of trovafloxacin.</p>

<p>Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.</p>

<p>MLEB-22043 is a synthetic siderophore-monocyclic β-lactam conjugate which enters bacteria through TonB-dependent transport proteins utilizing its siderophore component, subsequently exerting antibacterial activity via its β-lactam portion. This compound acts as a broad-spectrum antibiotic, exhibiting significant inhibitory activity against pathogens such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.</p>

<p>2-Acetyl-2-decarboxamidotetracycline is a tetracycline-class antibiotic. It exhibits a UV absorption spectrum similar to that of tetracycline or 5-oxytetracycline at concentrations above 300 mμ, characteristic of the BCD ring system.</p>

<p>Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.</p>

<p>Cilastatin ammonium salt is an antibiotic that is particularly effective against Gram-positive cocci, with a half-life of 3-4 hours.</p>

<p>Potent, selective CHS inhibitor with 0.12 mM IC50; effective against drug-resistant fungi.</p>

<p>Saptomycin E is an antitumor antibiotic.</p>

<p>Acetomycin, a γ-lactone from S. ramulosus, halts HCT-8 colon and L1210 leukemia cell growth.</p>

<p>Mal-PEG4-VA-PBD is a drug-linker conjugate for Antibody-Drug Conjugates (ADCs), comprising the antitumor antibiotic Pyrrolobenzodiazepine (PBD), connected</p>

<p>Ceftolozane TFA is a cephalosporin class antibiotic (antibiotic) designed to inhibit Gram-negative bacterial infections. Additionally, it can be utilized in the synthesis of novel antibiotics (antibiotic) that are more efficacious and safer.</p>

<p>Amicoumacin A has antibacterial activity. It also strongly suppresses inflammatory and ulcer activity.</p>

<p>Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).</p>

<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>

<p>Kinamycin B is an antibacterial agent with anticancer activity.</p>

<p>Antifungalagent 113 (compound 9a) serves as an effective antifungal and antibacterial agent. It exhibits strong inhibitory activity against both S. aureus and methicillin-resistant S. aureus.</p>

<p>Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4, demonstrating excellent antifungal activity against B. cinerea, with an EC50 value of 0.56 μg/mL.</p>

<p>Imidocarb dihydrochloride monohydrate is an effective antiprotozoal agent against the parasite B. bovis (IC50: 87 μg/ml).</p>

<p>TAN-1057C is a potent antibiotic with antimicrobial activity against both Gram-negative and Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA).</p>

<p>Nikkomycin Z (Nikkomycin Z from Streptomyces tendae) is a competitive chitin synthase inhibitor.It inhibitor of the growth of filamentous fungi, insects,</p>

<p>Cefamandole (lithium), a second-generation broad-spectrum cephalosporin antibiotic, exhibits antimicrobial activity. Upon metabolism in the body, it releases free NMTT, which can lead to hypoprothrombinemia.</p>