Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
- AMPK(158 produtos)
- ATM/ATR(71 produtos)
- DNA-PK(51 produtos)
- EGFR(572 produtos)
- MELK(7 produtos)
- PDK(9 produtos)
- PI3K(242 produtos)
- S6 Quinase(9 produtos)
- gsk-3(112 produtos)
- mTOR(144 produtos)
Exibir 2 mais subcategorias
Foram encontrados 1038 produtos de "Sinalização PI3K/Akt/mTOR"
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EGFR-IN-73
CAS:<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Fórmula:C19H17ClFN3O4Pureza:98%Cor e Forma:SolidPeso molecular:405.81Selatinib
CAS:<p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>Fórmula:C29H26ClFN4O3SPureza:98.00%Cor e Forma:SolidPeso molecular:565.06CGP52411
CAS:<p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>Fórmula:C20H15N3O2Pureza:99.78%Cor e Forma:SolidPeso molecular:329.35PI3K/mTOR Inhibitor-4
CAS:<p>Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.</p>Fórmula:C27H22FN3O6SCor e Forma:SolidPeso molecular:535.54BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Fórmula:C22H25N3OPureza:99.92%Cor e Forma:SolidPeso molecular:347.45GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Fórmula:C14H13N3OSPureza:98.58%Cor e Forma:SolidPeso molecular:271.34NVS-PI3-4
CAS:<p>NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.</p>Fórmula:C20H26N4O3SCor e Forma:SolidPeso molecular:402.51TC-G 24
CAS:<p>GSK-3β inhibitor</p>Fórmula:C15H11ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:330.73JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Fórmula:C24H28Cl2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:519.42(S)-PI3Kα-IN-4
CAS:<p>(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM.</p>Fórmula:C25H23ClFN5O5SCor e Forma:SolidPeso molecular:56018BIOder
CAS:<p>18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.</p>Fórmula:C9H7ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:210.62Tyrphostin 51
CAS:<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Fórmula:C13H8N4O3Pureza:98%Cor e Forma:SolidPeso molecular:268.23CHMFL-PI3KD-317
CAS:<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Fórmula:C21H24ClN5O3S2Pureza:99.16%Cor e Forma:SolidPeso molecular:494.03MS 39
CAS:<p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>Fórmula:C55H71ClFN9O7SCor e Forma:SolidPeso molecular:1056.72PI3KD/V-IN-01
CAS:<p>PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor.</p>Fórmula:C21H24ClN5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:494.03AZ2
CAS:<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Fórmula:C20H23N3O2SPureza:99.25%Cor e Forma:SolidPeso molecular:369.48Gefitinib N-oxide
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>Fórmula:C22H24ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:462.9Cazpaullone
CAS:<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Fórmula:C16H10N4OCor e Forma:SolidPeso molecular:274.28DBPR112
CAS:<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Fórmula:C32H31N5O3Pureza:99.25%Cor e Forma:SolidPeso molecular:533.62AM-0687
CAS:<p>AM-0687: Strong PI3Kδ blocker; pAKT IC50=0.7nM, u(pAKT) IC50=4.6nM; Rat IgG ED50=0.026mg/kg, IgM ED50=0.016mg/kg; Clu=2.3L/hr/kg.</p>Fórmula:C23H19FN8OPureza:98%Cor e Forma:SolidPeso molecular:442.45VP3.15
CAS:<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Fórmula:C17H19N3OSPureza:98.8%Cor e Forma:SolidPeso molecular:313.423,5-dimethyl PIT-1
CAS:<p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>Fórmula:C16H15N3O4SCor e Forma:SolidPeso molecular:345.37Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Fórmula:C15H14ClN3Pureza:95.15%Cor e Forma:SolidPeso molecular:271.74PI3K/mTOR Inhibitor-2
CAS:<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Fórmula:C20H13ClF2N4O4SPureza:96.16%Cor e Forma:SolidPeso molecular:478.86PI3Kdelta inhibitor 1
CAS:<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Fórmula:C27H38N6O5SPureza:98%Cor e Forma:SolidPeso molecular:558.69Mutated EGFR-IN-3
CAS:<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Fórmula:C31H29FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:508.59Nazartinib mesylate
CAS:<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Fórmula:C27H35ClN6O5SPureza:98%Cor e Forma:SolidPeso molecular:591.12DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Fórmula:C20H24N6O3Cor e Forma:SolidPeso molecular:396.44EGFR/HER2-IN-9
CAS:<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Fórmula:C25H25ClFN5O4Cor e Forma:SolidPeso molecular:513.95Lavendustin C6
CAS:<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Fórmula:C20H25NO5Cor e Forma:SolidPeso molecular:359.42Leniolisib phosphate
CAS:<p>Leniolisib phosphate is an effective PI3K inhibitor.</p>Fórmula:C21H28F3N6O6PCor e Forma:SolidPeso molecular:548.45BAY 2476568
CAS:<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Fórmula:C24H27FN4O4Cor e Forma:SolidPeso molecular:454.49EGFR-IN-55
CAS:<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Fórmula:C25H25Cl2N7O2Cor e Forma:SolidPeso molecular:526.42PKI-179
CAS:<p>PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.</p>Fórmula:C25H28N8O3Cor e Forma:SolidPeso molecular:488.54EGFR-IN-28
CAS:<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Fórmula:C31H39BrN10O3SCor e Forma:SolidPeso molecular:711.68SIKs-IN-1
CAS:<p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>Fórmula:C27H31F2N7OCor e Forma:SolidPeso molecular:507.58PI3K-IN-36
CAS:<p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>Fórmula:C30H36F2N8OCor e Forma:SolidPeso molecular:562.66PI3Kγ inhibitor 6
CAS:<p>PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.</p>Fórmula:C16H11NO5SCor e Forma:SolidPeso molecular:329.33PKI-179 hydrochloride
CAS:<p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>Fórmula:C25H29ClN8O3Cor e Forma:SolidPeso molecular:525PI3K-IN-28
CAS:<p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>Fórmula:C26H16F9N3O3S2Cor e Forma:SolidPeso molecular:653.54DNA-PK-IN-5
CAS:<p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>Fórmula:C21H22N8O2Cor e Forma:SolidPeso molecular:418.45CAY10717
CAS:<p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>Fórmula:C29H25F3N6O3Cor e Forma:SolidPeso molecular:562.54UNC-CA359
CAS:<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Fórmula:C18H14ClN3O2Cor e Forma:SolidPeso molecular:339.78EGFR-IN-49
CAS:<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Fórmula:C22H15N5O2SCor e Forma:SolidPeso molecular:413.45EGFR-IN-75
<p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>Fórmula:C10H6N6S2Cor e Forma:SolidPeso molecular:274.32PI3Kα-IN-4
CAS:<p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>Fórmula:C25H23ClFN5O5SCor e Forma:SolidPeso molecular:560(E/Z)-AG490
CAS:<p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>Fórmula:C17H14N2O3Cor e Forma:SolidPeso molecular:294.3PI3K-IN-2
CAS:<p>PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.</p>Fórmula:C28H29F2N3O5Cor e Forma:SolidPeso molecular:525.54PD 173955-Analog1
CAS:<p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>Fórmula:C21H14Cl2N4O3Cor e Forma:SolidPeso molecular:441.27
