Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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Tubulin inhibitor 12
CAS:<p>New tubulin inhibitor 12 (Hit 9); potent anti-cancer agent; IC50=25.3 μM; strong anti-tumor effect.</p>Fórmula:C24H20N2OCor e Forma:SolidPeso molecular:352.43BCR-ABL1-IN-1
CAS:<p>BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.</p>Fórmula:C18H12F3N3O2Cor e Forma:SolidPeso molecular:359.3KY-04031
CAS:<p>KY-04031 is an inhibitor of p21-activated kinase 4.</p>Fórmula:C21H20N8OCor e Forma:SolidPeso molecular:400.44AFG210
CAS:<p>AFG210 is a novel first-generation “type II” FLT3 inhibitor.</p>Fórmula:C19H14F3N3O2Cor e Forma:SolidPeso molecular:373.33BCR-ABL-IN-5
CAS:<p>BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.</p>Fórmula:C25H21Cl2N5O2Cor e Forma:SolidPeso molecular:494.37Iso-Fludelone
CAS:<p>Iso-Fludelone: a stable, soluble, potent, 3rd-gen epothilone B inhibiting cell division and inducing apoptosis, with low toxicity.</p>Fórmula:C27H36F3NO6Cor e Forma:SolidPeso molecular:527.5710-DEBC hydrochloride
CAS:<p>10-DEBC hydrochloride, a selective Akt inhibitor demonstrating an IC50 value of 1.28 μM, is identified as a novel anti-tuberculosis compound [1] [2].</p>Fórmula:C20H26Cl2N2OCor e Forma:SolidPeso molecular:381.34DRP1i27
CAS:<p>DRP1i27 inhibits human Drp1 at GTPase site, prevents mitochondrial fission, and shields cells from ischemia-reperfusion damage.</p>Fórmula:C20H26N6OCor e Forma:SolidPeso molecular:366.46KY-04045
CAS:<p>KY-04045 is a PAK4 inhibitor.</p>Fórmula:C13H14BrN5Cor e Forma:SolidPeso molecular:320.19NAMI-A
CAS:<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Fórmula:C8H15Cl4N4ORuSPureza:98%Cor e Forma:SolidPeso molecular:458.18SSTC3
CAS:<p>SSTC3 is a casein kinase 1α (CK1α) activator with potential antitumor activity that inhibits WNT signaling.</p>Fórmula:C23H17F3N4O3S2Pureza:98.65% - 99.94%Cor e Forma:SolidPeso molecular:518.53CHMFL-ABL-053
CAS:<p>CHMFL-ABL-053: potent, selective BCR-ABL/SRC/p38 inhibitor (IC50: 70/90/62 nM). Orally available, potential CML drug.</p>Fórmula:C28H26F3N7O2Cor e Forma:SolidPeso molecular:549.55BuChE-IN-5
CAS:<p>"BuChE-IN-5 is a potent inhibitor with an IC50 of 1.94 μM and shows promise for Alzheimer's research."</p>Fórmula:C25H35N3Cor e Forma:SolidPeso molecular:377.57Microtubule inhibitor 5
CAS:<p>Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.</p>Fórmula:C22H15FN2O4Cor e Forma:SolidPeso molecular:390.36AJH-836
CAS:<p>AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation of</p>Fórmula:C22H38O5Pureza:98%Cor e Forma:SolidPeso molecular:382.53Tubulin inhibitor 27
CAS:<p>DYT-1 Tubulin inhibitor 27, IC50: 25.6 μM, hinders tubulin polymerization, displays anti-angiogenic and antitumor effects.</p>Fórmula:C21H19NO4Cor e Forma:SolidPeso molecular:349.38Tubulin polymerization-IN-10
CAS:<p>Tubulin polymerization-IN-10 inhibits tubulin polymerization with 4.25 μM IC50 and has anti-tumor properties.</p>Fórmula:C18H21NO6SCor e Forma:SolidPeso molecular:379.43HSP90-IN-22
CAS:<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Fórmula:C25H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:434.53YM-1
CAS:<p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>Fórmula:C20H20ClN3OS2Cor e Forma:SolidPeso molecular:417.98Sibrafiban
CAS:<p>Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.</p>Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46Neuroinflammatory-IN-3
CAS:<p>Neuroinflammatory-IN-3 is a potent tubulin inhibitor with anti-neuroinflammatory and antitumor properties.</p>Fórmula:C19H19ClO3Cor e Forma:SolidPeso molecular:330.81Tubulin polymerization-IN-36
CAS:<p>Tubulin polymerization-IN-36, a cancer research agent for lymphomas, inhibits tubulin at the colchicine site with IC50 of 2.8 µM.</p>Fórmula:C18H18N2O3Cor e Forma:SolidPeso molecular:310.35Tubulin polymerization-IN-16
CAS:<p>Compound 5g is a potent tubulin aggregation inhibitor, disrupting microtubules and causing G2/M arrest in SGC-7901 cells.</p>Fórmula:C24H27N5O5Cor e Forma:SolidPeso molecular:465.5BCR-ABL-IN-6
CAS:<p>BCR-ABL-IN-6, an imatinib derivative, inhibits Bcr-AblWT (4.6 nM IC50) and T315I (277 nM), for chronic myeloid leukemia study.</p>Fórmula:C27H22F3N5O2Cor e Forma:SolidPeso molecular:505.49Retaspimycin
CAS:<p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>Fórmula:C31H45N3O8Pureza:98%Cor e Forma:SolidPeso molecular:587.7Tubulin polymerization-IN-15
CAS:<p>Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].</p>Fórmula:C18H17N3O4Cor e Forma:SolidPeso molecular:339.35Tubulin inhibitor 18
CAS:<p>"Tubulin inhibitor 18 (5j), a potent chalcone, uniquely structured for cancer research."</p>Fórmula:C22H26O5Cor e Forma:SolidPeso molecular:370.44Tubulin polymerization-IN-18
CAS:<p>Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.</p>Fórmula:C25H25NO6Cor e Forma:SolidPeso molecular:435.47GNF-1331
CAS:<p>GNF-1331: potent, selective oral porcupine inhibitor; IC50=12 nM; targets aberrant Wnt signaling in cancers.</p>Fórmula:C20H20N6O2S2Cor e Forma:SolidPeso molecular:440.54Synstab A
CAS:<p>Synstab A is a microtubule stabilizer.</p>Fórmula:C15H13BrCl3N3O3SCor e Forma:SolidPeso molecular:501.61KUNB31
CAS:<p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>Fórmula:C19H18N2O3Cor e Forma:SolidPeso molecular:322.36Microtubule inhibitor 7
CAS:<p>Compounds 17o and 17p have IC50s of 14.0 nM and 2.9 nM respectively, in NCI-H460 cancer cells, showing potent activity.</p>Fórmula:C25H19FN2O5Cor e Forma:SolidPeso molecular:446.43(S)-Dolaphenine hydrochloride
CAS:<p>(S)-Dolaphenine hydrochloride is a useful componet of compound synthesis.</p>Fórmula:C11H13ClN2SPureza:98%Cor e Forma:SolidPeso molecular:240.75Dihydrocytochalasin B
CAS:<p>Dihydrocytochalasin B (H2CB) is a cell division inhibitor that inhibits cytokinesis and alters cell morphology.</p>Fórmula:C29H39NO5Pureza:98%Cor e Forma:SolidPeso molecular:481.62MK-0668
CAS:<p>MK-0668 is a very potent and orally active very late antigen-4 antagonist.</p>Fórmula:C31H30Cl2N6O6SCor e Forma:SolidPeso molecular:685.58Tau tracer 1
CAS:<p>Tau tracer 1 is a radiopharmaceutical for imaging Tau aggregates linked to neurodegenerative disease diagnosis.</p>Fórmula:C34H23N5O2Cor e Forma:SolidPeso molecular:533.591Deox B 7,4
CAS:<p>Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.</p>Fórmula:C18H18O5Cor e Forma:SolidPeso molecular:314.33SW02
CAS:<p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>Fórmula:C19H23BrN2O5Cor e Forma:SolidPeso molecular:439.3Tubulin polymerization-IN-30
CAS:<p>Compound 6e inhibits tubulin polymerization, disrupts microtubules, halts G2/M phase, and targets HeLa, SGC-7901, A549 with low IC50.</p>Fórmula:C22H25N5O3Cor e Forma:SolidPeso molecular:407.47Tubulin inhibitor 29
CAS:<p>Compound 3c, a tubulin inhibitor, blocks assembly at colchicine site with IC50 of 1.2 μM; anti-proliferative IC50 7.5 μM in MCF-7 cells.</p>Fórmula:C12H8F2O2S2Cor e Forma:SolidPeso molecular:286.32Microtubule inhibitor 6
CAS:<p>Compound 17o inhibits microtubules, toxic to NCI-H460, BxPC-3, HT-29 cells (IC50: 14.0, 6.6, 7.0 nM), blocks polymerization.</p>Fórmula:C24H19FN2O5Cor e Forma:SolidPeso molecular:434.42Tubulin inhibitor 31
<p>Tubulin inhibitor 31: potent with 4 µM IC50, anti-proliferative, inhibits HUVEC migration.</p>Fórmula:C22H19NO2Cor e Forma:SolidPeso molecular:329.39BCR-ABL-IN-1
CAS:<p>BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.</p>Fórmula:C23H21F4N5OPureza:98%Cor e Forma:SolidPeso molecular:459.44PD-173956
CAS:<p>PD-173956 is an inhibitor of the Src family tyrosine kinases.</p>Fórmula:C20H13Cl2FN4OCor e Forma:SolidPeso molecular:415.25Tubulin polymerization-IN-7
CAS:<p>Tubulin aggregation-IN-7 is a potent tubulin aggregation inhibitor that has shown research potential for cancer diseases.</p>Fórmula:C28H24N4O6SCor e Forma:SolidPeso molecular:544.58PF-06651481-00
CAS:<p>PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.</p>Fórmula:C26H29Cl2N5O3Pureza:97.01%Cor e Forma:SolidPeso molecular:530.45β-glycosidase-IN-1
CAS:<p>β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.</p>Fórmula:C13H23NO5Pureza:98%Cor e Forma:SolidPeso molecular:273.33TCS 2314
CAS:<p>TCS 2314 is an orally active and selective very late antigen-4 antagonist (IC50: 4.4 nM).</p>Fórmula:C28H34N4O6Pureza:98%Cor e Forma:SolidPeso molecular:522.59Anticancer agent 60
CAS:<p>Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.</p>Fórmula:C27H33N5O4SCor e Forma:SolidPeso molecular:523.65Cevipabulin
CAS:<p>Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell</p>Fórmula:C18H18ClF5N6OPureza:99.53%Cor e Forma:SolidPeso molecular:464.82
