Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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Microtubule inhibitor 1
CAS:<p>Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells).</p>Fórmula:C21H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:333.38Tubulin inhibitor 28
CAS:<p>Compound 2g, a tubulin inhibitor with an IC50 of 1.2 μM, inhibits MCF-7 cell proliferation.</p>Fórmula:C12H8Br2S2Cor e Forma:SolidPeso molecular:376.13ARUK3001185
CAS:<p>ARUK3001185 (8l): potent, selective Notum inhibitor; oral, brain-penetrant; IC50=6.7 nM; for rodent disease models.</p>Fórmula:C9H4Cl2F3N3Cor e Forma:SolidPeso molecular:282.05CHPG sodium salt
CAS:<p>CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways.</p>Fórmula:C8H7ClNNaO3Pureza:>99.99%Cor e Forma:SolidPeso molecular:223.59Valategrast
CAS:<p>Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.</p>Fórmula:C30H32Cl3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:604.95Cardionogen 1
CAS:<p>Wnt signaling modulator</p>Fórmula:C13H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:274.34EMD534085
CAS:<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>Fórmula:C25H31F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:476.53Wnt/β-catenin agonist 1
CAS:<p>Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM).</p>Fórmula:C22H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:363.45BCR-ABL-IN-2
CAS:<p>BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).</p>Fórmula:C24H25Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:502.39Bimoclomol
CAS:<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Fórmula:C14H20ClN3O2Cor e Forma:SolidPeso molecular:297.78UR-1505
CAS:<p>UR-1505 is an NF-AT inhibitor that prevents T cell activation without reducing cell viability.</p>Fórmula:C10H7F5O4Pureza:98%Cor e Forma:SolidPeso molecular:286.15c-ABL-IN-2
CAS:<p>C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.</p>Fórmula:C21H20N4OCor e Forma:SolidPeso molecular:344.41AKT-IN-7
CAS:<p>AKT-IN-7 (compound 1-P1) is a potent inhibitor of AKT. AKT-IN-7 has potential for cancer research.</p>Fórmula:C23H27ClN6O2Cor e Forma:SolidPeso molecular:454.95YW1128
CAS:<p>YW1128 inhibits Wnt/β-catenin signaling (IC50=4.1 nM), reduces β-catenin, affects gene expression, and improves glucose tolerance and weight control in mice.</p>Fórmula:C20H17N5OCor e Forma:SolidPeso molecular:343.38MT-7
CAS:<p>MT-7 is a tubulin polymerization inhibitor.</p>Fórmula:C22H17N3O2Pureza:98%Cor e Forma:SolidPeso molecular:355.39Kif15-IN-1
CAS:<p>Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.</p>Fórmula:C20H22N4O5SPureza:99.39% - 99.39%Cor e Forma:SolidPeso molecular:430.48Anticancer agent 49
CAS:<p>Anticancer agent 49, also 69, hinders cell growth and microtubule aggregation, with potential in solid and blood cancer research.</p>Fórmula:C26H25N3O4Cor e Forma:SolidPeso molecular:443.49Tubulin polymerization-IN-19
CAS:<p>Tubulin aggregation-IN-19 (compound 4) is a potent tubulin aggregation inhibitor that has shown potential in breast cancer and drug-resistant colon cancer.</p>Fórmula:C25H25NO5Cor e Forma:SolidPeso molecular:419.47HSP90-IN-12
CAS:<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Fórmula:C25H36O4Cor e Forma:SolidPeso molecular:400.55DJ101
CAS:<p>DJ101: A stable tubulin inhibitor that bypasses multidrug resistance efflux pumps.</p>Fórmula:C23H20N4O3Pureza:98%Cor e Forma:SolidPeso molecular:400.43Hsp90-IN-15
CAS:<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Fórmula:C23H27F3N4Cor e Forma:SolidPeso molecular:416.48YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Fórmula:C27H27N3O4S3Cor e Forma:SolidPeso molecular:553.72Displurigen
CAS:<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Fórmula:C15H10O4SPureza:98%Cor e Forma:SolidPeso molecular:286.3AKT-IN-9
CAS:<p>AKT-IN-9, a potent AKT inhibitor, may aid breast/prostate cancer studies. See WO2021185238A1.</p>Fórmula:C24H29ClN6OCor e Forma:SolidPeso molecular:452.98ZW4864 free base
CAS:<p>ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.</p>Fórmula:C33H42N6O3Pureza:99.81%Cor e Forma:SolidPeso molecular:570.72Box5
CAS:<p>Box5 blocks Wnt5a, reducing Ca2+ release and cell migration; promising for melanoma studies.</p>Fórmula:C30H50N6O13S2Cor e Forma:SolidPeso molecular:766.88Malonganenone A
CAS:<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Fórmula:C26H38N4O2Cor e Forma:SolidPeso molecular:438.61Mivobulin
CAS:<p>Mivobulin is an inhibitor of tubulin .</p>Fórmula:C17H19N5O2Pureza:98%Cor e Forma:SolidPeso molecular:325.37NC043
CAS:<p>NC043 is an inhibitor of Wnt/β-catenin signaling, it forms a covalent bond with the Cys-516 residue of CARF.</p>Fórmula:C20H26O4Pureza:98%Cor e Forma:SolidPeso molecular:330.42KIF18A-IN-3
CAS:<p>KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.</p>Fórmula:C28H38N4O5S2Pureza:98.45%Cor e Forma:SolidPeso molecular:574.76Zaurategrast ethyl ester
CAS:<p>Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.</p>Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46IMB-10
CAS:<p>IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.</p>Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Fórmula:C20H22F2N4O2SCor e Forma:SolidPeso molecular:420.48CH5138303
CAS:<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Fórmula:C19H18ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:415.9Tau protein aggregation-IN-1
CAS:<p>Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders</p>Fórmula:C17H11BrN2O2Cor e Forma:SolidPeso molecular:355.19CK2-IN-9
CAS:<p>CK2-IN-9, a potent and selective CK2 kinase inhibitor, exhibits an inhibitory concentration (IC50) of 3 nM against its target enzyme and hampers Wnt reporter</p>Fórmula:C23H29N9OCor e Forma:SolidPeso molecular:447.54Zaurategrast ethyl ester sulfate
CAS:<p>Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.</p>Fórmula:C56H60Br2N8O10SPureza:98%Cor e Forma:SolidPeso molecular:1197.01Tubulin polymerization-IN-27
CAS:<p>Compound 5j inhibits tubulin polymerization, arrests cell cycle at G2/M phase, and induces apoptosis.</p>Fórmula:C22H20N2O2Cor e Forma:SolidPeso molecular:344.41CK548
CAS:<p>CK548 is a novel actin-related protein (Arp)2/3 complex inhibitor.</p>Fórmula:C15H11BrClNO2SPureza:98%Cor e Forma:SolidPeso molecular:384.68SC-10
CAS:<p>SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.</p>Fórmula:C17H22ClNO2SPureza:99.24% - 99.58%Cor e Forma:SolidPeso molecular:339.88MG-2119
CAS:<p>MG-2119 is a potent inhibitor of monomeric tau and α-syn aggregation and can be used to study neurological diseases.</p>Fórmula:C27H29N5O4Cor e Forma:SolidPeso molecular:487.55AN-019
CAS:<p>AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.</p>Fórmula:C25H17F6N5OPureza:98.99%Cor e Forma:SolidPeso molecular:517.43isoCA-4
CAS:<p>isoCA-4 is a Combretastatin A4 derivative. isoCA-4 is a tubulin polymerization inhibitor with anti-proliferative activities [1].</p>Fórmula:C18H20O5Cor e Forma:SolidPeso molecular:316.35Tubulin polymerization-IN-29
CAS:<p>Tubulin polymerization-IN-29 inhibits microtubule assembly, has anti-proliferative properties, and arrests HeLa cells at G2/M.</p>Fórmula:C25H20FNO6Cor e Forma:SolidPeso molecular:449.43BNC105P
CAS:<p>BNC105P, a prodrug VDA, converts to BNC105, blocks tubulin polymerization, disrupts tumor vessels, and evades P-glycoprotein resistance.</p>Fórmula:C20H21O10PCor e Forma:SolidPeso molecular:452.34856BrCaQ
CAS:<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Fórmula:C18H15BrN2O3Cor e Forma:SolidPeso molecular:387.23Ellipticine quinone
CAS:<p>Ellipticine quinone (NSC-383230) outperforms mdivi-1 in inhibiting Drp1, reduces lung cancer growth, and lessens IR injury by curbing mitochondrial issues.</p>Fórmula:C15H8N2O2Cor e Forma:SolidPeso molecular:248.24Dynamin IN-1
CAS:<p>Dynamin IN-1 is a potent dynamin inhibitor with an IC 50 value of 1.0 µM .</p>Fórmula:C23H24N2OCor e Forma:SolidPeso molecular:344.45PU3
CAS:<p>PU3 is an inhibitor of Hsp90.</p>Fórmula:C19H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:371.43Conteltinib
CAS:<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Fórmula:C32H45N9O3SPureza:98.12% - 99.54%Cor e Forma:SolidPeso molecular:635.82
