Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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para-Nitroblebbistatin
CAS:<p>para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II.Cost-effective and quality-assured.</p>Fórmula:C18H15N3O4Pureza:99.09% - 99.84%Cor e Forma:SolidPeso molecular:337.33Rosabulin
CAS:<p>v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.</p>Fórmula:C22H16N4O2SPureza:98.06%Cor e Forma:SolidPeso molecular:400.45JB062
CAS:<p>JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac</p>Fórmula:C19H17NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:323.34Elarofiban
CAS:<p>Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.</p>Fórmula:C22H32N4O4Pureza:98.76%Cor e Forma:SolidPeso molecular:416.51JB002
CAS:<p>JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM.</p>Fórmula:C18H15NO3Pureza:99.74%Cor e Forma:SoildPeso molecular:293.32LY3372689
CAS:<p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>Fórmula:C16H22FN5O3SPureza:99.43% - 99.53%Cor e Forma:SolidPeso molecular:383.44DCPLA-ME
CAS:<p>DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative</p>Fórmula:C21H38O2Pureza:99.80%Cor e Forma:SolidPeso molecular:322.53CID-663143
CAS:<p>CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.</p>Fórmula:C19H18N4O2SPureza:99.68% - 99.77%Cor e Forma:SolidPeso molecular:366.44BIRT-377
CAS:<p>BIRT-377: orally active, hinders ICAM-1/LFA-1, blocks IL-2, useful for immune research. (Ki=25.8 nM).</p>Fórmula:C18H15BrCl2N2O2Pureza:99.93%Cor e Forma:SolidPeso molecular:442.13Nilotinib hydrochloride
CAS:<p>Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.</p>Fórmula:C28H23ClF3N7OPureza:>99.99%Cor e Forma:SolidPeso molecular:565.98TCS 2210
CAS:<p>TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.</p>Fórmula:C18H17N3O3Pureza:98.62%Cor e Forma:SolidPeso molecular:323.35SB-216
CAS:<p>SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.</p>Fórmula:C17H18N4O2Pureza:99.70%Cor e Forma:SolidPeso molecular:310.35AMP-PCP disodium
CAS:<p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>Fórmula:C11H16N5Na2O12P3Pureza:99.32%Cor e Forma:SolidPeso molecular:549.17BMD4503-2
CAS:<p>BMD4503-2 is a competitive inhibitor of the LRP5/6-sclerostin complex that restores the activity of the Wnt/β-catenin signaling pathway cancer.</p>Fórmula:C26H21N5O3SPureza:99.18%Cor e Forma:SolidPeso molecular:483.54JB061
<p>JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle</p>Fórmula:C19H17NO4Pureza:99.67%Cor e Forma:SoildPeso molecular:323.34NSC668394
CAS:<p>NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.</p>Fórmula:C17H12Br2N2O3Pureza:99.29% - 99.29%Cor e Forma:SolidPeso molecular:452.1CMPF
CAS:<p>CMPF is a microtubule protein inhibitor that can be used to study tumors.</p>Fórmula:C12H16O5Pureza:99.88%Cor e Forma:SolidPeso molecular:240.25AZ13705339
CAS:<p>AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.</p>Fórmula:C33H36FN7O3SPureza:99.77%Cor e Forma:SolidPeso molecular:629.75DZ2002
CAS:<p>DZ2002: Oral, reversible SAHH inhibitor (Ki=17.9 nM), low-toxicity, immunosuppressive, counters dermal fibrosis, used in autoimmune research.</p>Fórmula:C10H13N5O3Pureza:99.91%Cor e Forma:SolidPeso molecular:251.24JH-VIII-157-02
CAS:<p>JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.</p>Fórmula:C28H27N5O2Pureza:99.58%Cor e Forma:SolidPeso molecular:465.55Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Fórmula:C14H20ClN3O3Pureza:99.15%Cor e Forma:SolidPeso molecular:313.78ZINC00640089
CAS:<p>ZINC00640089: Selective LCN2 inhibitor; curbs SUM149 cell growth and AKT activity; useful for IBC research.</p>Fórmula:C20H13F3N2O2Pureza:98.41% - 99.80%Cor e Forma:SolidPeso molecular:370.32DM1-SMe
CAS:<p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>Fórmula:C36H50ClN3O10S2Pureza:99.61%Cor e Forma:SolidPeso molecular:784.38Defactinib hydrochloride
CAS:<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Cor e Forma:SolidPeso molecular:546.95PPY A
CAS:<p>PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cells</p>Fórmula:C22H20N4O2Pureza:98.77%Cor e Forma:SolidPeso molecular:372.42Iroxanadine
CAS:<p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>Fórmula:C14H20N4OPureza:98.04% - 99.04%Cor e Forma:SolidPeso molecular:260.33Tubulin inhibitor 8
CAS:<p>Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.</p>Fórmula:C21H14N2O3Pureza:98.51% - 99.87%Cor e Forma:SolidPeso molecular:342.35Elsibucol
CAS:<p>Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant,</p>Fórmula:C35H54O4S2Pureza:99.73%Cor e Forma:SolidPeso molecular:602.93AKT-IN-6
CAS:<p>AKT-IN-6 (INCB-047775) inhibits Akt, a key signaling protein linked to type 2 diabetes and cancer.</p>Fórmula:C22H20FN5OPureza:98.68%Cor e Forma:SolidPeso molecular:389.43Terflavoxate
CAS:<p>Terflavoxate is a novel, orally active, semisynthetic statin microtubule inhibitor commonly used in combination with capecitabine.</p>Fórmula:C26H29NO4Pureza:98%Cor e Forma:SolidPeso molecular:419.51Firategrast
CAS:<p>Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous</p>Fórmula:C27H27F2NO6Pureza:99.16%Cor e Forma:SolidPeso molecular:499.5SNX0723
CAS:<p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>Fórmula:C22H26FN3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:399.46Erbulozole
CAS:<p>Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.</p>Fórmula:C24H27N3O5SPureza:99.88%Cor e Forma:SolidPeso molecular:469.55Bis-T-23
CAS:<p>Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative.</p>Fórmula:C23H20N4O8Pureza:96.81% - 98.13%Cor e Forma:SolidPeso molecular:480.43Dynapyrazole A
CAS:<p>Dynapyrazole A inhibits dynein 1 and 2 (IC50s: 2.3, 2.6 μM) and Hedgehog signaling (IC50: 1.9 μM).</p>Fórmula:C20H12ClIN4OPureza:98.01%Cor e Forma:SolidPeso molecular:486.69UMK57
CAS:<p>UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,</p>Fórmula:C17H17N3SPureza:99.81%Cor e Forma:SolidPeso molecular:295.4EMT inhibitor-1
CAS:<p>EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.</p>Fórmula:C12H12Cl2N2O2SPureza:99.53%Cor e Forma:SolidPeso molecular:319.21JG-231
CAS:<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Fórmula:C22H18BrCl2N3OS4Pureza:99.79%Cor e Forma:SolidPeso molecular:619.47ASN90
CAS:<p>ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.</p>Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45AKT-IN-13
CAS:<p>AKT-IN-13 inhibits Akt1, Akt2, Akt3 (IC50: 1.6, 2.4, 0.3 nM); used in cancer research.</p>Fórmula:C24H31ClN6O2Cor e Forma:SolidPeso molecular:470.99ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Fórmula:C15H11BrN2O2SPureza:99.67%Cor e Forma:SolidPeso molecular:363.23ATN-161
CAS:<p>ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.</p>Fórmula:C23H35N9O8SPureza:98%Cor e Forma:SolidPeso molecular:597.64MAO A/HSP90-IN-2
CAS:<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Fórmula:C25H31ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:458.98VTX-27
CAS:<p>VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).</p>Fórmula:C20H24ClFN6OPureza:99.84%Cor e Forma:SolidPeso molecular:418.9WAY 316606 hydrochloride
CAS:<p>WAY 316606 hydrochloride is a chemical compound that serves as an inhibitor of sFRP-1 (secreted protein), which functions as an endogenous antagonist of the Wnt (secreted glycoprotein). Its affinity for sFRP-1 is measured through the FP (fluorescence polarization) binding assay, revealing an IC50 (half maximal inhibitory concentration) of 0.5 μM [1].</p>Fórmula:C18H20ClF3N2O4S2Cor e Forma:SolidPeso molecular:484.94CCT251455
CAS:<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Fórmula:C26H26ClN7O2Pureza:99.1% - 99.1%Cor e Forma:SolidPeso molecular:503.98TAK 029
CAS:<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Fórmula:C19H23N5O7Cor e Forma:SolidPeso molecular:433.42JG-23
CAS:<p>JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of</p>Fórmula:C19H16ClN3OS2Cor e Forma:SolidPeso molecular:401.93Tubulin polymerization-IN-52
CAS:<p>Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].</p>Fórmula:C21H18F3N5O3Cor e Forma:SolidPeso molecular:445.39Oxaline
CAS:<p>Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].</p>Fórmula:C24H25N5O4Cor e Forma:SolidPeso molecular:447.49
