Bioquímicos e reagentes

<p>Fmoc-Cys(Trt)-OH is a chemical compound that has been shown to have potent antitumor activity in mice. It is synthesized by the stepwise addition of amino acids to the resin-bound Cys residue in the presence of trifluoroacetic acid and a coupling agent such as EDC. This reaction produces a functional protein with an amide bond. The acetylcholine receptor binding properties of Fmoc-Cys(Trt)-OH are due to its ability to form a disulfide bond with cysteine residues on the receptor.</p>

<p>Eptifibatide is a drug that is used in the treatment of congestive heart failure, acute coronary syndrome and peripheral artery disease. It is a glycoprotein IIb/IIIa inhibitor that binds to integrin receptors on platelets and prevents them from binding to fibrinogen. This prevents blood clotting and reduces the risk of stroke or heart attack. Eptifibatide has been shown to be effective for the treatment of bowel disease, infectious diseases, and experimental models of myocardial infarcts. The drug has significant cytotoxicity, which may be due to its ability to inhibit cell proliferation by blocking protein synthesis at the ribosome level.<br>Eptifibatide has been shown to have a disulfide bond between two cysteine residues located in its amino-terminal region. This bond stabilizes the molecule in solution and ensures that it remains active until it reaches its target site.</p>

<p>H-VVFNHFYNIKLPMGSQCSVD-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VVFNHFYNIKLPMGSQCSVD-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VVFNHFYNIKLPMGSQCSVD-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VVFNHFYNIKLPMGSQCSVD-OH at the technical inquiry form on this page</p>

<p>Ac-Tyr-Val-Gly is a mitochondrial protein that regulates mitochondrial functions and is involved in the regulation of apoptosis. Ac-Tyr-Val-Gly interacts with nuclear DNA and regulates transcription, translation, and replication. Ac-Tyr-Val-Gly has been shown to be toxic to liver cells; however, it has been shown to have no effect on neuronal death or apoptosis pathway. These effects may be due to its ability to induce proteolytic activity in neurons and its ability to activate proapoptotic proteins such as Bax.</p>

<p>1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose is a per-O-acetylated version of 5-alkynyl-L-fucose, an inhibitor of the cellular fucosylation pathway. 1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose can pass through the eukaryotic cell membrane somewhat better than 5-alkynyl-L-fucose can itself, is deacetylated by cellular esterases and interferes with the biosynthesis of the fucosyl-donor and fucosyltransferase substrate GDP-Fuc, thus reducing fucosylation levels during glycoprotein biosynthesis.</p>

<p>mGluR5 antagonist</p>

<p>Tos-Lys-OMe.HCl is a peptide substrate for the enzyme trypsin, which is an endopeptidase that cleaves proteins to smaller fragments. Tos-Lys-OMe.HCl is used in the study of proteolytic enzyme action and as a tool in biochemical research.</p>

<p>The H-Lys(Boc)-2-ClTrt-Resin is a resin used in peptide synthesis. The resin is a crosslinkable polystyrene with an amine functionality that can be used to synthesize peptides. This resin contains the thiols, building blocks, and alcohols necessary for the synthesis of peptides. The H-Lys(Boc)-2-ClTrt-Resin is available in two mesh sizes: 200 mesh or 400 mesh.</p>

<p>Please enquire for more information about Cy3 DiC18 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about C.I.Acid Orange 87 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Met-MCA is a peptide that can be used as an activator, antibody, or receptor. CAS No. 94367-34-7. It is a high purity product with high quality and good stability in salt solution or in PBS (PH 7.4). It inhibits ion channels and has been shown to inhibit the interactions of proteins. Met-MCA can be used as a pharmacological tool for research on protein interactions and ligand/receptor binding.</p>

<p>Prolactin Mouse Monoclonal Antibody is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Prolactin Mouse Monoclonal Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Almitrine-raubasine is a drug that has been used in China to treat metabolic disorders. It is a mixture of two drugs, almitrine and raubasine. Almitrine-raubasine increases the metabolic rate and ATP levels by inhibiting the enzyme activity of phosphofructokinase in mitochondria. This drug also has been shown to be effective for slowing down the growth of cancer cells. Almitrine-raubasine may have potential as a drug target for cancer treatment or other metabolic diseases, such as diabetes mellitus or obesity.</p>

<p>Valsartan is an angiotensin receptor blocker that is used to treat hypertension and in combination with other antihypertensive agents. This drug works by binding to the angiotensin receptor 1 (AT1) and preventing angiotensin II from binding and exerting its hypertensive effects. This leads to a reduction in blood pressure and reduced cardiac activity.</p>

<p>Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.</p>

<p>Inhibits proteosomes of class peptide epoxyketone; antineoplastic</p>

<p>Please enquire for more information about C.I.Direct green 85 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Galactosyl-Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a monoclonal antibody that binds to the integrin receptor, which is involved in the proliferation and migration of cells. It has been shown to be an effective treatment for prostate cancer cells in vitro. Galactosyl-Cyclo(Arg-Gly-Asp-D-Phe-Lys) also shows potential as a biomarker for atherosclerotic lesions. The drug has been shown to have pharmacokinetic properties in humans and can inhibit epidermal growth factor (EGF) activity.</p>

<p>CYP17 lyase inhibitor; androgen receptor antagonist</p>

<p>Antagonist of H1 histamine receptors</p>

<p>Des-n-Octanoyl-[Ser3]-Ghrelin (Human, 1-14) is a non-Acylated Analog of Ghrelin (Human, 1-14), amino acids 1-14 of the peptide hormone Ghrelin. This peptide does not contain the unique N-octanoyl group which is linked to Ghrelin's third serine residue covalently and which allows Ghrelin to associate with the growth hormone secretagogue receptor (GHS-R). Through interaction with the GHS-R, Ghrelin can exert its various effects on the body such as stimulating appetite, nutrient sensing, meal initiation and the regulation of insulin resistance, diabetes and obesity. Its wider functions are also associated with glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.</p>

<p>Formyl peptide receptor-1 (FPR-1) antagonist</p>

<p>H-IGPGGDGPGG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-IGPGGDGPGG-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-IGPGGDGPGG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-IGPGGDGPGG-OH at the technical inquiry form on this page</p>

<p>Androgen receptor (AR) antagonist</p>

<p>H-GVLYVGSKTKE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GVLYVGSKTKE-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GVLYVGSKTKE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GVLYVGSKTKE-OH at the technical inquiry form on this page</p>

<p>Sparteine hydroiodide is the salt form of sparteine. This compound acts as an inhibitor of voltage-gated sodium channels. In organic chemisty, it is used for chiral synthesis.</p>

<p>Anastrozole is a non-steroidal drug that belongs to the class of aromatase inhibitors. It inhibits the production of estrogen by blocking the conversion of androgens to estrogens in peripheral tissues. The drug has been shown to be effective in treating breast cancer in postmenopausal women. In vitro assays have shown that Anastrozole can inhibit tumor growth as well as induce apoptosis in human serum cells, which suggests that it may be effective against a variety of cancers.</p>

<p>Fmoc-His(Trt)-Wang Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis that contains Fmoc-His(Trt) and 1% DVB. It is used to synthesize peptides with Fmoc chemistry.</p>

<p>BMP7 is a protein that belongs to the TGF-β superfamily. It is a potent inhibitor of bone resorption in vitro and in vivo. BMP7 also has been shown to inhibit the synthesis of collagenase and other proteases by osteoclasts, leading to decreased bone resorption. This protein activates receptors for insulin-like growth factor and activin, which are proteins produced by bone cells (osteoblasts) that regulate bone formation. BMP7 can also be used as a research tool for studying receptor activation, ligand binding, or ion channel function.</p>

<p>Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID), which is a synthetic derivative of salicylic acid. It is primarily sourced through chemical synthesis rather than extraction from natural elements. Diflunisal functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a crucial role in the biosynthesis of prostaglandins. This inhibition results in reduced production of prostaglandins, compounds involved in inflammation and pain signaling pathways.</p>

<p>H-LLWTLVVLL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLWTLVVLL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLWTLVVLL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLWTLVVLL-OH at the technical inquiry form on this page</p>

<p>Tandospirone is a psychotropic drug that acts as a selective serotonin receptor partial agonist. It is derived from a synthetic source, specifically targeting the 5-HT1A receptors in the brain. Tandospirone modulates serotonergic neurotransmission by binding to these receptors, which are associated with mood regulation. This action results in the anxiolytic and antidepressant effects observed with the drug.</p>

<p>VEGFR2 a tyrosine kinase receptor inhibitor; antineoplastic</p>

<p>RIPK2 protein kinase inhibitor; EGFR inhibitor</p>

<p>Abz-Gly-Phe-Ser-Pro-Tyr(NO2)-OH is a peptide that can be used as an angiotensin I converting enzyme II substrate. It is a synthetic, non-peptide molecule that has been shown to inhibit the activity of the angiotensin I converting enzyme (ACE). This inhibition prevents the conversion of angiotensin I to angiotensin II, which leads to vasodilation and decreased blood pressure.</p>

<p>TIC10 is a small molecule, which is sourced from a synthetic chemical library, with a novel mode of action that involves the induction of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway. This pathway is distinguished by its ability to selectively trigger apoptosis in cancer cells while sparing normal cells. TIC10 effectively crosses the blood-brain barrier, a feature that enhances its potential application in treating brain-related malignancies.</p>

<p>Lanreotide is a somatostatin analog that is used for the treatment of tumors and acromegaly. This drug inhibits the growth hormone in the brain and induces apoptosis. Lanreotide also has antiproliferative properties as it blocks production that leads to tumor growth.</p>

<p>Rabeprazole is a proton pump inhibitor drug that is used to treat symptoms of GERD, heal gastrointestinal ulcers and eradicate Helicobacter pylori. This antiulcer drug suppresses gastric acid by inhibiting the gastric H+/K+ ATPase at the parietal cell.</p>

<p>H-GRAMYAPPIEGNITC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GRAMYAPPIEGNITC-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GRAMYAPPIEGNITC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GRAMYAPPIEGNITC-OH at the technical inquiry form on this page</p>

<p>H-KLTVDKSRWQQGNVFSCS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KLTVDKSRWQQGNVFSCS-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KLTVDKSRWQQGNVFSCS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KLTVDKSRWQQGNVFSCS-OH at the technical inquiry form on this page</p>

<p>H-YPGNGDTSYNQKFKGKAT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YPGNGDTSYNQKFKGKAT-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YPGNGDTSYNQKFKGKAT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YPGNGDTSYNQKFKGKAT-OH at the technical inquiry form on this page</p>

<p>Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplastic</p>

<p>This product is a Liver-Expressed Antimicrobial Peptide of Canine source containing the disulfide Bonds: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, and Cys14-Cys22. Hepcidin is a peptide hormone that controls the release of iron from storage cells in the liver. It inhibits erythropoiesis by limiting the availability of iron for red blood cell production. This peptide also exhibits anti-microbial properties in that in response to inflammatory cytokines hepcidin leads to a decreased release of iron from enterocytes, hepatocytes and macrophages and further leads to ferroportin degradation and internalization. This product may be useful for use in research into disorders where iron dysregulation is paramount for pathogenesis and also in inflammatory diseases.</p>

<p>Pantoprazole is a proton pump inhibitor drug that is used to treat erosive esophagitis and promotes healing of tissue damage caused by gastric acid. It is used for the management of GERD. Through the proton pump inhibition, the formation of hydrochloric acid is inhibited thus inhibiting gastric secretion.</p>

<p>Please enquire for more information about C.I.Solvent Orange 56 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>C.I. Vat Orange 15 is a polymerization inhibitor that prevents polymerization by reacting with the hydrogen peroxide, which is generated during the chemical reaction. The addition of C.I. Vat Orange 15 to a polymerization system will slow down the reaction and increase the yield of the desired product. This chemical can also be used in organic solvents and a variety of other reactions, such as light resistance and surfactant production. It is not soluble in water and requires an organic solvent for use in coatings or resins, but it does not react with esters or ethers. C.I. Vat Orange 15 has been shown to have high concentrations, but it is not toxic to animals or humans.&gt;&gt;END&gt;&gt;</p>

<p>Please enquire for more information about C.I.Solubilised Sulphur green 3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-GCTASIVLLQAFR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GCTASIVLLQAFR-OH is provided at greater that Flashpure (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GCTASIVLLQAFR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GCTASIVLLQAFR-OH at the technical inquiry form on this page</p>

<p>Sphingosine-1-phosphate receptor modulator</p>

<p>Please enquire for more information about C.I.Disperse Violet 96 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>