Heterociclos com Nitrogénio (N)

<p>Applications 2-Isopropylthio-5-trifluoromethylpyridine-3-boronic acid<br></p>

<p>Applications 2-(1H-pyrazol-4-yl)aniline (cas# 1342757-33-8) is a useful research chemical.<br></p>

<p>Applications 3,4-Dimethyl-5-pyrazolone (cas# 6628-22-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Di(tert-butoxy)pyrimidine-5-boronic acid<br></p>

<p>Applications 3-Chloro-4-cyanopyridine (cas# 68325-15-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors.<br>References Roy, P., et al.: PCT Int. Appl., 2010:777979 (2010);<br></p>

<p>Applications 1,2,3,6-Tetrahydropyridine (cas# 694-05-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride-D5 is an intermediate in the synthesis of Piperacillin-d5 (P479952), which is the labeled analogue of Piperacillin (P479950), an antibacterial agent.<br>References Takai, A., et al.: Chemotherapy, 25, 816 (1977), Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978), Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978),<br></p>

<p>Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).<br></p>

<p>Applications 6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia.<br>References Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23 (16), 4493 (2013);<br></p>

<p>Applications N-Tosylpyrrole (cas# 17639-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 6,​8-​Dibromo-​3,​4-​dihydro-​3,​3-​bis(1-​pyrrolidinylmethyl)​-2H-1-benzopyran-4-ol is a useful synthetic reagent.<br></p>

<p>Applications 2,4-Dichloro-6-vinylpyrimidine used to synthesize polymers containing pyrimidine.<br>References Sugiki, T., et al.: J. Photopoly. Sci. Technol., 8, 9 (1995);<br></p>

<p>Applications 5-Bromopyrimidine (cas# 4595-59-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Nitro-1,2,3-triazole is a highly impact sensitive and explosive material.<br>References Politzer, P. et al.: Int. J. Quant. Chem., 61, 389 (1997);<br></p>

<p>Applications Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate-d3 is labelled Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate (P698600) which is a useful synthetic intermediate.<br></p>

<p>Stability Volatile<br>Applications C6H8N2O2 (cas# 19213-72-0) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 1-Ethyl-5-hydroxy-2-pyrrolidinone (E919175), an important organic solvent used in varnishing. Industrial solvent.<br>References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);<br></p>

<p>Applications N-Butyryl-4-(S)-phenylmethyl-2-oxazolidinone (cas# 112459-79-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(6-hydrazinylpyrimidin-4-yl)morpholine (cas# 5767-36-2) is a useful research chemical.<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Pyrazinecarboxylic Acid 4-Oxide (cas# 874-54-4) is a compound useful in organic synthesis.<br>References Ambrogi, V., et al.: Eur. J. Med. Chem., 15, 157 (1980),<br></p>

<p>Applications 5-Hydroxy-6-methylpicolinic Acid is used as a reactant in the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channels.<br>References Hadida Ruah, Sara S., et al.: U.S. Pat. Appl. Publ., US 20120196869 A1 20120802 (2012)<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications 5-Hydroxy-4,6-dimethyl-3-pyridinemethanol is used in the study of sphingosine-1-phosphate is a major chemoattractant and stem cell mobilization factor.<br>References Ratajczak, M.Z., et al.: Leukemia, 24, 976 (2010)<br></p>

<p>Applications 4-Ethylpyridine is a general chemical reagent used in the synthesis of substituted pyridines as well as diverse azacyclic compounds.<br>References Gandhamsetty, N. et al.: J. Am. Chem. Soc., 137, 15176 (2015); Chen, X. et al.: J. Coord. Chem., 68, 2835 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Aminopyrimidine-5-boronic acid<br></p>

<p>Applications Pyridine-2,6-d2 (CAS# 17265-96-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-[4-(3-Pyrrolidinyl)1,3-thiazol-2yl]guanidine is a reagent which is used in biological studies as antiulcer agent.<br>References Gupta, S., et al.: J. Chem. Info. Comp. Sci, 39, 272 (1999)<br></p>

<p>Applications 5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid (cas# 543739-84-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>

<p>Applications 5-Phenyl-4h-1,2,4-triazol-3-amine, is an intermediate in the synthesis of WP155. 5-Phenyl-4h-1,2,4-triazol-3-amine is also used in biological studies to evaluate its pharmacological activity as it can be applied to a method for reducing susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof.<br>References Truman, B., et al.: U.S. Pat. Appl. Publ.<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications 4,6-Dichloroimidazo[4,5-c]pyridine (cas# 2589-12-0) is a compound useful in organic synthesis.<br></p>

<p>Applications [1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (cas# 3176-50-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 9-Hydroxy-pyrido[1,2-a]pyrimidin-4-one is used in treatment of glioma.<br>References Bush, Ashley. Prana Biotechnology Limited. (2007);<br></p>

<p>Applications A substituted pyrimidine used in the study for prediction of relative potency of ketone protease inhibitors using molecular orbital theory.<br>References Chan, A. W. E., et al.: Bioorg. Med. Chem., 4, 1673 (1996),<br></p>

<p>Applications 2,4-Dimethoxypyrimidine, is a versatile building block used in synthesis of various chemical compounds, such as derivatives of Cytidine (C998300).<br>References Kammerer, B., et al.: Anal. Biol. Chem., 382, 1017 (2005); Strong, L. and Matsunaga, H.: J. Surg. Oncol., 4, 528 (1972)<br></p>

<p>Applications 2-Acetylpyridine is an aroma and flavour compound present in foods.<br>References Roberts, D. et al.: J. Agri. Food, Chem., 43, 2179 (1995); Buttery, R. et al.: J. Agri. Food Chem., 46, 2764 (1996);<br></p>

<p>Applications 3-(N-1-Trityl-imidazol-4-yl)propionic Acid is an intermediate used to prepare imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase. It is also used in the synthesis of nonracemic arylpiperazinone analogs of the carboxyl-terminal CAAL sequence of protein geranylgeranyltransferase-I (PGGTase-I) as selective inhibitors of PGGTase-I and of protein farnesyltransferase.<br>References Ding, C., et al.: J. Med. Chem., 42, 5241 (1999); Peng, H., et al.: Org. BIomol. Chem., 4, 1768 (2006)<br></p>

<p>Applications Heterocyclic compound used in cosmetic compositions.<br>References Windheuser, J., et al.: J. Pharm. Sci., 71, 121 (1982), Davis, E., et al.: J. Med. Entomol., 22, 237 (1985), Osimitz, T., et al.: J. Toxicol., 35, 435 (1997), Ross, E., et al.: Drug Metab. Dispos., 32, 783 (2004),<br></p>

<p>Applications 2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications 2-ethoxy-3-ethylpyrazine (cas# 35243-43-7) is a useful research chemical.<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-one (cas# 1114596-75-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-2,4,6-trimethylpyridine<br></p>

<p>Applications 2-Mercapto-5-nitrobenzimidazole is useful for treating giardiasis. Antigiardial drug.<br>References Hernandez-Ochoa, B., et al.: Molecules, 25, 3979 (2020)<br></p>

<p>Applications 6-(Ethylamino)pyridine-3-carbonitrile<br></p>

<p>Applications A boc-protected cyclic amine used in the preparation of heterocyclic boronic acid compounds.<br></p>

<p>Impurity Olmesartan Imidazole Diethyl Ester Impurity<br>Applications An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)<br></p>

<p>Applications [1,2,4]Triazolo[1,5-a]pyridin-8-ol can be used to prepare aminopyridine derivatives as glucokinase activators useful to treat diseases.<br>References Aicher, T. D., et al.: PCT Int. Appl., 145, (2008);<br></p>

<p>Applications 5-(trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione (cas# 2145-56-4) is a useful research chemical.<br></p>