Compostos Heterocíclicos

<p>Applications 4,4-dimethyldihydrofuran-2,3-dione (cas# 13031-04-4) is a useful research chemical.<br></p>

<p>Applications Ethyl 1-Piperazine-d8-acetate 2HCl is a useful isotopically labeled compound<br></p>

<p>Applications Phenazine (cas# 92-82-0) is a compound useful in organic synthesis.<br></p>

<p>Applications (2,4-Dioxo-thiazolidin-3-yl)-acetic Acid is a useful compound for preparation of novel thiazolidinedione-​hydroxamates as Zmp1 inhibitors.<br>References Slachtova, V., et al.: Eur. J. Med. Chem., 185, 111812 (2020)<br></p>

<p>Applications N-Nitroso-3-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.<br>References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)<br></p>

<p>Applications 2-carboxythiophene-3-boronic acid (cas# 5503-74-2) is a useful research chemical.<br></p>

<p>Applications Phenazine methosulfate is a compound used to determine nitric oxide reductase activity. Used in the discovery of potent bromophenazine antibacterial agents against Staphylococcus.<br>References Watanabe, A. et al.: Neurosci., 339, 139 (2016);<br></p>

<p>Applications Tetrahydrofuran-2,5-dicarboxylic acid (CAS# 6338-43-8) is a useful research chemical compound.<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>